Islet abnormalities in the pathogenesis of autoimmune diabetes

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice

1997 • 1,011 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Gestational Diabetes Mellitus

1986 • 646 citations

Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.

1999 • 633 citations

Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model

1995 • 607 citations

Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition

1992 • 481 citations

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes

2000 • 456 citations

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

1996 • 340 citations

Heterogeneity of Type I diabetes: analysis of monozygotic twins in Great Britain and the United States

2001 • 314 citations

Autoimmune type 1 diabetes: resolved and unresolved issues

2001 • 306 citations

Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?

2000 • 292 citations

Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program.

1996 • 279 citations

The Endocrine pancreas

1991 • 261 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

Differentiation of New Insulin-Producing Cells Is Induced by Injury in Adult Pancreatic Islets¹

1997 • 231 citations

Release of Incompletely Processed Proinsulin Is the Cause of the Disproportionate Proinsulinemia of NIDDM

1997 • 212 citations

Genetic Protection from the Inflammatory Disease Type 1 Diabetes in Humans and Animal Models

2001 • 205 citations

Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.

1999 • 191 citations

On the pathogenesis of IDDM

1994 • 181 citations

Is childhood-onset Type I diabetes a wealth-related disease? An ecological analysis of European incidence rates

2001 • 180 citations

T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins

1990 • 179 citations

Birth weight and childhood onset type 1 diabetes: population based cohort study

2001 • 173 citations

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model

1995 • 162 citations

Structural and Functional Considerations of GABA in Islets of Langerhans: β-Cells and Nerves

1991 • 157 citations

Genetically Programmed Development of Salivary Gland Abnormalities in the NOD (Nonobese Diabetic)-scidMouse in the Absence of Detectable Lymphocytic Infiltration: A Potential Trigger for Sialoadenitis of NOD Mice

1996 • 117 citations

Evidence That a Peptide Spanning the B-C Junction of Proinsulin Is an Early Autoantigen Epitope in the Pathogenesis of Type 1 Diabetes

2001 • 116 citations

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.

1995 • 103 citations

Glucose regulation of the autoantigen GAD65 in human pancreatic islets.

1992 • 100 citations

Autoimmune type 1 diabetes: resolved and unresolved issues

2001 • 99 citations

Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.

1995 • 92 citations

Prevalence and Predictive Value of Islet Cell Antibodies and Insulin Autoantibodies in Women with Gestational Diabetes

1994 • 87 citations

Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

1995 • 86 citations

Islet autoantibodies in cord blood from children who developed Type I (insulin-dependent) diabetes mellitus before 15 years of age

1999 • 82 citations

Differentiation of New Insulin-Producing Cells Is Induced by Injury in Adult Pancreatic Islets

1997 • 77 citations

Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice.

1997 • 77 citations

Translating Data from Animal Models into Methods for Preventing Human Autoimmune Diabetes Mellitus: Caveat Emptor and Primum non Nocere

2001 • 76 citations

Genetic susceptibility factors in type 1 diabetes: linkage, disequilibrium and functional analyses

1998 • 73 citations

Concordance for Type 1 Diabetes in Identical Twins Is Affected by Insulin Genotype

2001 • 72 citations

Evidence of beta cell dysfunction which does not lead on to diabetes: a study of identical twins of insulin dependent diabetics.

1987 • 68 citations

Glucose Homeostasis in the Nonobese Diabetic Mouse at the Prediabetic Stage¹

1998 • 67 citations

α-Cell Neogenesis in an Animal Model of IDDM

1997 • 66 citations

Association of polymorphism in the NeuroD/BETA2 gene with type 1 diabetes in the Japanese.

1999 • 65 citations

Islet Abnormalities Associated with an Early Influx of Dendritic Cells and Macrophages in NOD and NODscid Mice

2000 • 65 citations

Glucose regulation of the autoantigen GAD65 in human pancreatic islets

1992 • 63 citations

Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM

1997 • 55 citations

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1997 • 55 citations

Abnormalities in dendritic cell and macrophage accumulation in the pancreas of nonobese diabetic (NOD) mice during the early neonatal period.

2002 • 53 citations

Autoimmune diabetes: the role of the islets of langerhans

1996 • 51 citations

Structural and functional considerations of GABA in islets of Langerhans. Beta-cells and nerves

1991 • 51 citations

The Functional State of the Beta Cells in the Pathogenesis of Insulin-Dependent Diabetes Mellitus

1991 • 45 citations

NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group.

2000 • 43 citations

Sex Steroids Influence Pancreatic Islet Hypertrophy and Subsequent Autoimmune Infiltration in Nonobese Diabetic (NOD) and NODscid Mice

2001 • 42 citations

Analysis of Candidate Genes for Susceptibility to Type I Diabetes: A Case-Control and Family-Association Study of Genes on Chromosome 2q31–35

1997 • 40 citations

Defect of the First-Phase Insulin Secretion to Glucose Stimulation in the Perfused Pancreas of the Nonobese Diabetic (NOD) Mouse

1986 • 36 citations

TheNEURODGene Maps to Human Chromosome 2q32 and Mouse Chromosome 2

1996 • 36 citations

Insulin and glucagon in spontaneously diabetic non-obese mice

1984 • 33 citations

Functional and morphological effects of interleukin-1? on the perfused rat pancreas

1990 • 33 citations

Beta-cell behaviour during the prediabetic stage. Part II. Non-insulin-dependent and insulin-dependent diabetes mellitus.

1997 • 31 citations

Prophylactic insulin treatment in relatives at high risk for type 1 diabetes

1993 • 31 citations

The Offspring of the Female Diabetic "Nonobese Diabetic" (NOD) Mouse Are Large for Gestational Age and Have Elevated Pancreatic Insulin Content: A New Animal Model of Human Diabetic Pregnancy

1987 • 31 citations

Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats

1993 • 29 citations

Genetics of autoimmune diabetes in animal models

1998 • 28 citations

Localization of gamma-aminobutyric acid and glutamic acid decarboxylase in the pancreas of the nonobese diabetic mouse.

1996 • 27 citations

alpha-Cell neogenesis in an animal model of IDDM

1997 • 23 citations

Islet Endocrine-Cell Behavior From Birth Onward in Mice With the Nonobese Diabetic Genetic Background

2001 • 22 citations

Augmentation of basal insulin release from rat islets by preexposure to a high concentration of glucose

2000 • 21 citations

Glucose Homeostasis in the Nonobese Diabetic Mouse at the Prediabetic Stage

1998 • 17 citations

The immunologic insult in type 1 diabetes

1993 • 16 citations

Neonatal anthropometric measurements and risk of childhood-onset type 1 diabetes

1999 • 16 citations

Treatment of Prediabetic Patients with Insulin: Experience and Future

1996 • 15 citations

Effects of insulin administration in a group of high‐risk, non‐diabetic, first‐degree relatives of Type 1 diabetic patients: an open pilot trial

1999 • 13 citations

Analysis of candidate genes for susceptibility to type I diabetes: a case-control and family-association study of genes on chromosome 2q31-35

1997 • 12 citations

High proinsulin levels in late PRE-IDDM stage

1997 • 12 citations

Defect of the first-phase insulin secretion to glucose stimulation in the perfused pancreas of the nonobese diabetic (NOD) mouse

1986 • 10 citations

Localization of gamma-aminobutyric acid and glutamic acid decarboxylase in the pancreas of the nonobese diabetic mouse

1996 • 9 citations