High proinsulin levels in late PRE-IDDM stage

Insulin Resistance is a Prominent Feature of Insulin-dependent Diabetes

1982 • 365 citations

Natural Course of Insulin Resistance in Type I Diabetes

1986 • 301 citations

Competitive Insulin Autoantibody Assay: Prospective Evaluation of Subjects at High Risk for Development of Type I Diabetes Mellitus

1987 • 181 citations

Hyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humans.

1996 • 88 citations

Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of Type 1 (insulin-dependent) diabetic patients

1988 • 80 citations

Disproportionately elevated proinsulin levels precede the onset of insulin-dependent diabetes mellitus in siblings with low first phase insulin responses. The Childhood Diabetes in Finland Study Group.

1994 • 69 citations

Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of type I diabetes mellitus

1987 • 64 citations

Between and within subject variation of the first phase insulin response to intravenous glucose

1988 • 62 citations

Relationship Between First-Phase Insulin Secretion and Age, HLA, Islet Cell Antibody Status, and Development of Type I Diabetes in 220 Juvenile First-Degree Relatives of Diabetic Patients

1991 • 46 citations

The Design of Trials for Prevention of IDDM

1993 • 33 citations

Elevated Proinsulin Levels Related to Islet Cell Antibodies in First-Degree Relatives of IDDM Patients

1992 • 32 citations

The design of trials for prevention of IDDM

1993 • 17 citations

Disproportionately elevated proinsulin levels precede the onset of insulin-dependent diabetes mellitus in siblings with low first phase insulin responses. The Childhood Diabetes in Finland Study Group

1994 • 14 citations

Proinsulin Immunoreactivity in Recent-Onset IDDM: The significance of insulin antibodies and insulin autoantibodies

1996 • 14 citations