Advanced glycation end products inhibit de novo protein synthesis and induce TGF-β overexpression in proximal tubular cells

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Advanced Glycosylation End Products in Patients with Diabetic Nephropathy

1991 • 925 citations

N ε-(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression

1999 • 848 citations

The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?

1999 • 623 citations

Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A

2001 • 620 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo

1991 • 534 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

Alterations in nonenzymatic biochemistry in uremia: Origin and significance of “carbonyl stress” in long-term uremic complications

1999 • 515 citations

Immunochemical detection of advanced glycosylation end products in vivo.

1992 • 496 citations

Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency.

1994 • 473 citations

Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice

2001 • 470 citations

Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors

1991 • 451 citations

Patterns of renal injury in NIDDM patients with microalbuminuria

1996 • 405 citations

Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose

2000 • 312 citations

Chelating Activity of Advanced Glycation End-product Inhibitors

2001 • 311 citations

Advanced Glycation End Product-induced Apoptosis and Overexpression of Vascular Endothelial Growth Factor and Monocyte Chemoattractant Protein-1 in Human-cultured Mesangial Cells

2002 • 308 citations

Possible Participation of Autocrine and Paracrine Vascular Endothelial Growth Factors in Hypoxia-induced Proliferation of Endothelial Cells and Pericytes

1995 • 300 citations

Advanced Glycation End Products-driven Angiogenesis in Vitro

1997 • 272 citations

Hemoglobin-AGE: A Circulating Marker of Advanced Glycosylation

1992 • 255 citations

Redox-mediated activation of latent transforming growth factor-beta 1

1996 • 245 citations

Progression of Nephropathy in Spontaneous Diabetic Rats Is Prevented by OPB-9195, a Novel Inhibitor of Advanced Glycation

1997 • 229 citations

Renal interstitial expansion in insulin-dependent diabetes mellitus

1993 • 229 citations

Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195

1999 • 213 citations

Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells

1998 • 197 citations

Neurotoxicity of Advanced Glycation End-Products for Cultured Cortical Neurons

2000 • 195 citations

Immunological Evidence that Non-carboxymethyllysine Advanced Glycation End-products Are Produced from Short Chain Sugars and Dicarbonyl Compounds in vivo

2000 • 193 citations

Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: Altered expression of vascular endothelial growth factor

2000 • 192 citations

The renal tubulointerstitium in diabetes mellitus

1991 • 169 citations

Evolving natural history of coronary artery disease in diabetes mellitus

1991 • 150 citations

Clinical and Histological Correlations of Decline in Renal Function in Diabetic Patients With Proteinuria

1994 • 149 citations

Role of glomerular ultrafiltration of growth factors in progressive interstitial fibrosis in diabetic nephropathy

2000 • 146 citations

Vascular endothelial growth factor acts as a pericyte mitogen under hypoxic conditions.

1999 • 140 citations

Receptor-Mediated Toxicity to Pericytes of Advanced Glycosylation End Products: A Possible Mechanism of Pericyte Loss in Diabetic Microangiopathy

1995 • 129 citations

Intermittent high glucose enhances cell growth and collagen synthesis in cultured human tubulointerstitial cells

1999 • 128 citations

Ellenberg and Rifkin's Diabetes Mellitus: Theory and Practice

1991 • 126 citations

Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment.

1999 • 125 citations

Detection of Noncarboxymethyllysine and Carboxymethyllysine Advanced Glycation End Products (AGE) in Serum of Diabetic Patients

1999 • 120 citations

Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency

2000 • 114 citations

Advanced Glycation Endproducts Accelerate Calcification in Microvascular Pericytes

1999 • 109 citations

Lysozyme Enhances Renal Excretion of Advanced Glycation Endproducts In Vivo and Suppresses Adverse AGE-mediated Cellular Effects In Vitro: A Potential AGE Sequestration Therapy for Diabetic Nephropathy?

2001 • 69 citations

Diabetic Renal Disease.

1951 • 67 citations

Endothelin-1 Mediates Endothelial Cell-Dependent Proliferation of Vascular Pericytes

1993 • 67 citations

Insulin Stimulates the Growth and Tube Formation of Human Microvascular Endothelial Cells through Autocrine Vascular Endothelial Growth Factor

1999 • 56 citations

Advanced glycosylation end products stimulate the growth but inhibit the prostacyclin‐producing ability of endothelial cells through interactions with their receptors

1996 • 48 citations

Oral Adsorbent AST-120 Ameliorates Interstitial Fibrosis and Transforming Growth Factor-β<sub>1</sub> Expression in Spontaneously Diabetic (OLETF) Rats

2000 • 45 citations

Biphasic effect of oxygen radicals on prostaglandin production by rat mesangial cells

1987 • 32 citations

Induction of Cyclooxygenase‐2 by Overexpression of the Human Catalase Gene in Cerebral Microvascular Endothelial Cells

2000 • 27 citations