The Ets transcription factors of the PEA3 group: Transcriptional regulators in metastasis

Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer

2005 • 3,714 citations

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

1992 • 1,787 citations

The ETS-domain transcription factor family

2001 • 1,033 citations

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG

1994 • 727 citations

Molecular biology of the Ets family of transcription factors

2003 • 649 citations

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

2001 • 627 citations

A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.

1995 • 466 citations

ETS Gene Er81 Controls the Formation of Functional Connections between Group Ia Sensory Afferents and Motor Neurons

2000 • 458 citations

A new member of the ETS family fused to EWS in Ewing tumors

1997 • 386 citations

Matrilysin: An epithelial matrix metalloproteinase with potentially novel functions

1996 • 370 citations

Biology of EWS/ETS fusions in Ewing's family tumors

2001 • 344 citations

Specificity within the ets Family of Transcription Factors

1998 • 343 citations

Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.

1992 • 338 citations

Functionally Related Motor Neuron Pool and Muscle Sensory Afferent Subtypes Defined by Coordinate ETS Gene Expression

1998 • 328 citations

The ETS-domain transcription factor family

1997 • 322 citations

ERM is required for transcriptional control of the spermatogonial stem cell niche

2005 • 314 citations

Cyclooxygenase-2 Is Overexpressed in HER-2/neu-positive Breast Cancer

2002 • 312 citations

DNA-Binding and Transcriptional Activation Properties of the EWS-FLI-1 Fusion Protein Resulting from the t(l1;22) Translocation in Ewing Sarcoma

1994 • 304 citations

Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins.

1992 • 267 citations

DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma.

1994 • 241 citations

Fusion of anETS-family gene,EIAF, toEWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy

1996 • 229 citations

A Novel Chimera Gene betweenEWSandE1A-F, Encoding the Adenovirus E1A Enhancer-Binding Protein, in Extraosseous Ewing's Sarcoma

1996 • 170 citations

The PEA3 Subfamily of Ets Transcription Factors Synergizes with β-Catenin–LEF-1 To Activate Matrilysin Transcription in Intestinal Tumors

2001 • 169 citations

The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

2000 • 164 citations

Androgen Receptor-Ets Protein Interaction Is a Novel Mechanism for Steroid Hormone-mediated Down-modulation of Matrix Metalloproteinase Expression

1996 • 154 citations

HER2/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer

1997 • 152 citations

Differential expression patterns of the PEA3 group transcription factors through murine embryonic development

1997 • 147 citations

Systematic Identification and Analysis of Mammalian Small Ubiquitin-like Modifier Substrates

2004 • 144 citations

The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades.

1996 • 143 citations

PEA3 Is Up-regulated in Response to Wnt1 and Activates the Expression of Cyclooxygenase-2

2001 • 133 citations

Molecular phylogeny of the ETS gene family

1999 • 130 citations

Changes in the Expression of Many Ets Family Transcription Factors and of Potential Target Genes in Normal Mammary Tissue and Tumors

2004 • 130 citations

Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters.

1995 • 128 citations

The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis

2001 • 127 citations

Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf

2003 • 126 citations

Analysis of the ERK-Stimulated ETS Transcription Factor ER81

1996 • 121 citations

A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells.

1996 • 117 citations

Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors.

1994 • 108 citations

Biallelic Mutations in p16^INK4a Confer Resistance to Ras- and Ets-Induced Senescence in Human Diploid Fibroblasts

2002 • 104 citations

HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1

2001 • 102 citations

Acetylation-Mediated Transcriptional Activation of the ETS Protein ER81 by p300, P/CAF, and HER2/Neu

2003 • 102 citations

Ets Gene PEA3 Cooperates with β-Catenin-Lef-1 and c-Jun in Regulation of Osteopontin Transcription

2004 • 95 citations

Expression of the PEA3 group of ETS-related transcription factors in human breast-cancer cells

1997 • 91 citations

HER2/Neu- and TAK1-mediated Up-regulation of the Transforming Growth Factor β Inhibitor Smad7 via the ETS Protein ER81

2003 • 90 citations

Structure–Function Relationships of the PEA3 Group of Ets-Related Transcription Factors

1997 • 89 citations

Regulation of the ETS Transcription Factor ER81 by the 90-kDa Ribosomal S6 Kinase 1 and Protein Kinase A

2002 • 89 citations

Elevated β1,4-Galactosyltransferase I in Highly Metastatic Human Lung Cancer Cells

2004 • 89 citations

Association of ets‐related transcriptional factor E1AF expression with tumour progression and overexpression of MMP‐1 and matrilysin in human colorectal cancer

2003 • 88 citations

Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes

2000 • 87 citations

Binding of an ETS-related protein within the DNase I hypersensitive site of the HER2/neu promoter in human breast cancer cells.

1994 • 87 citations

Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of theetsoncogene family

1993 • 85 citations

The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA.

1996 • 82 citations

PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas.

1993 • 80 citations

Molecular characterization of the ets-related human transcription factor ER81.

1995 • 77 citations

Male Sexual Dysfunction in Mice Bearing Targeted Mutant Alleles of thePEA3 etsGene

2000 • 74 citations

The PEA3 Ets transcription factor is a downstream target of the HER2/Neu receptor tyrosine kinase

1998 • 73 citations

Multiple chromosomal mechanisms generate an EWS/FLI1 or an EWS/ERG fusion gene in Ewing tumors

1997 • 67 citations

Expression of PEA3/E1AF/ETV4, an Ets-related transcription factor, in breast tumors: positive links to MMP2, NRG1 and CGB expression

2003 • 67 citations

The PEA3 Ets Transcription Factor Comprises Multiple Domains That Regulate Transactivation and DNA Binding

2001 • 66 citations

Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer

2003 • 65 citations

The transcription of the intercellular adhesion molecule-1 is regulated by Ets transcription factors

1998 • 64 citations

Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines.

1996 • 63 citations

Molecular analysis of cell surface beta-1,4-galactosyltransferase function during cell migration.

1994 • 62 citations

Molecular characterization of the zebrafish PEA3 ETS-domain transcription factor

1998 • 60 citations

Polyoma Enhancer Activator 3, an Ets Transcription Factor, Mediates the Induction of Cyclooxygenase-2 by Nitric Oxide in Colorectal Cancer Cells

2004 • 57 citations

The search for BRCA1.

1994 • 57 citations

PEA3 transactivates vimentin promoter in mammary epithelial and tumor cells.

1996 • 57 citations

Expression patterns of the Ets transcription factors from the PEA3 group during early stages of mouse development

2001 • 56 citations

Antisense E1AF transfection restrains oral cancer invasion by reducing matrix metalloproteinase activities.

1997 • 56 citations

PEA3 transcription factors are expressed in tissues undergoing branching morphogenesis and promote formation of duct-like structures by mammary epithelial cells in vitro

2003 • 56 citations

Expression of E1AF/PEA3, an Ets-related transcription factor in human non-small-cell lung cancers: Its relevance in cell motility and invasion

2001 • 54 citations

Increased E1AF expression in mouse fibrosarcoma promotes metastasis through induction of MT1-MMP expression

1999 • 53 citations

ERM, a PEA3 Subfamily of Ets Transcription Factors, Can Cooperate with c-Jun

1995 • 52 citations

Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis

2005 • 51 citations

Two functionally distinct domains responsible for transactivation by the Ets family member ERM.

1996 • 46 citations

PEA3 and AP-1 Are Required for Constitutive IL-8 Gene Expression in Hepatoma Cells

2000 • 45 citations

PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma.

2003 • 44 citations

Expression of E1AF, an ets-family transcription factor, is correlated with the invasive phenotype of oral squamous cell carcinoma

1997 • 44 citations

Meningitis caused by Streptococcus pneumoniae showing high level resistance to penicillin

1995 • 44 citations

Expression and regulation of the meprin ? gene in human cancer cells

1999 • 43 citations

SUMO Modification of the Ets-related Transcription Factor ERM Inhibits Its Transcriptional Activity

2005 • 42 citations

Prognostic Value of ERM Gene Expression in Human Primary Breast Cancers

2004 • 39 citations

The ETS family member ERM contains an alpha-helical acidic activation domain that contacts TAFII60

1997 • 39 citations

Prognostic Significance of Matrix Metalloproteinase‐7 (MMP‐7) Expression at the Invasive Front in Gastric Carcinoma

2002 • 38 citations

Up-regulation of ERM/ETV5 correlates with the degree of myometrial infiltration in endometrioid endometrial carcinoma

2005 • 37 citations

ERM Transactivation Is Up-regulated by the Repression of DNA Binding after the PKA Phosphorylation of a Consensus Site at the Edge of the ETS Domain

2002 • 34 citations

Upregulation of the matrix metalloproteinase‐1 gene by the Ewing's sarcoma associated EWS‐ER81 and EWS‐Fli‐1 oncoproteins, c‐Jun and p300

2003 • 31 citations

Metastasis-associated murine melanoma cell surface galactosyltransferase: characterization of enzyme activity and identification of the major surface substrates.

1990 • 30 citations

E1AF, an ets-oncogene family transcription factor

2004 • 30 citations

In vitro galactosylation of a 110-kDa glycoprotein by an endogenous cell surface galactosyltransferase correlates with the invasiveness of adrenal carcinoma cells.

1989 • 30 citations

hTERT Is Highly Expressed in Ewing???s Sarcoma and Activated by EWS-ETS Oncoproteins

2004 • 28 citations

The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions

2004 • 27 citations

Pea3 Transcription Factor Cooperates with USF-1 in Regulation of the Murine bax Transcription without Binding to an Ets-binding Site

2004 • 27 citations

Genomic Organization of the Human ERM (ETV5) Gene, a PEA3 Group Member of ETS Transcription Factors

1996 • 27 citations

Characterization of the human and mouse ETV1/ER81 transcription factor genes: role of the two alternatively spliced isoforms in the human

1999 • 26 citations

PEA3 Transactivates the Muc4/Sialomucin Complex Promoter in Mammary Epithelial and Tumor Cells

2003 • 24 citations

Clinical significance of PEA3 in human breast cancer

2002 • 22 citations

The 26S proteasome system degrades the ERM transcription factor and regulates its transcription-enhancing activity

2006 • 20 citations

Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo

2002 • 18 citations

E1AF degradation by a ubiquitin–proteasome pathway

2004 • 16 citations

E1AF expression is closely correlated with malignant phenotype of tongue squamous cell carcinoma through activation of MT1-MMP gene promoters

2005 • 16 citations

E1A‐F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase‐2 and matrix metalloproteinase‐7

2005 • 15 citations

Ectopic expression of the ets transcription factor ER81 in transgenic mouse mammary gland enhances both urokinase plasminogen activator and stromelysin-1 transcription.

2002 • 12 citations

Genomic organization of the human e1af gene,a member of Ets transcription factors

1999 • 10 citations

Suppressing HER2/neu-Mediated Cell Transformation by Transcriptional Repressors

2000 • 7 citations