The ETS-domain transcription factor family

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

1996 • 1,115 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

The Ets family of transcription factors

1993 • 848 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

1995 • 546 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.

1995 • 466 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events

1996 • 365 citations

Oligomerization of the ABL Tyrosine Kinase by the Ets Protein TEL in Human Leukemia

1996 • 349 citations

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1996 • 338 citations

Defective activation and survival of T cells lacking the Ets-1 transcription factor

1995 • 329 citations

Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway

1995 • 327 citations

The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

1994 • 315 citations

Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene

1995 • 313 citations

A new pattern for helix–turn–helix recognition revealed by the PU.l ETS–domain–DNA complex

1996 • 307 citations

MafB Is an Interaction Partner and Repressor of Ets-1 That Inhibits Erythroid Differentiation

1996 • 291 citations

The t(12;21) Translocation Converts AML-1B from an Activator to a Repressor of Transcription

1996 • 284 citations

Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation

1993 • 278 citations

Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).

1995 • 255 citations

Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins

1995 • 244 citations

Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter.

1996 • 244 citations

Protein Synthesis Inhibitors Reveal Differential Regulation of Mitogen-Activated Protein Kinase and Stress-Activated Protein Kinase Pathways That Converge on Elk-1

1995 • 243 citations

Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.

1996 • 237 citations

Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.

1995 • 235 citations

Net, a new ets transcription factor that is activated by Ras.

1994 • 216 citations

Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice

1996 • 204 citations

Gene regulation by Ets proteins

1993 • 199 citations

Activation of ternary complex factor Elk-1 by stress-activated protein kinases

1995 • 190 citations

Spi-1/PU.1 Transgenic Mice Develop Multistep Erythroleukemias

1996 • 187 citations

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

1994 • 186 citations

A direct physical association between ETS and AP-1 transcription factors in normal human T cells

1995 • 184 citations

Modulation of Transcription Factor Ets-1 DNA Binding: DNA-Induced Unfolding of an α Helix

1995 • 177 citations

Spatial flexibility in ternary complexes between SRF and its accessory proteins.

1992 • 175 citations

The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.

1995 • 165 citations

ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.

1995 • 163 citations

Solution structure of the ETS domain from murine Ets-1: a winged helix-turn-helix DNA binding motif.

1996 • 157 citations

Androgen Receptor-Ets Protein Interaction Is a Novel Mechanism for Steroid Hormone-mediated Down-modulation of Matrix Metalloproteinase Expression

1996 • 154 citations

An Immunological Renal Disease in Transgenic Mice That Overexpress Fli-1, a Member of the ets Family of Transcription Factor Genes

1995 • 146 citations

TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain.

1994 • 146 citations

The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1.

1994 • 145 citations

Characterization of the Cooperative Function of Inhibitory Sequences in Ets-1

1996 • 145 citations

The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades.

1996 • 143 citations

The Drosophila E74 gene is required for metamorphosis and plays a role in the polytene chromosome puffing response to ecdysone

1995 • 129 citations

Analysis of the ERK-Stimulated ETS Transcription Factor ER81

1996 • 121 citations

ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development.

1994 • 121 citations

Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP.

1996 • 120 citations

JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye

1995 • 118 citations

Functional Interaction of c-Ets-1 and GHF-1/Pit-1 Mediates Ras Activation of Pituitary-Specific Gene Expression: Mapping of the Essential c-Ets-1 Domain

1995 • 116 citations

Generation of a Novel Fli-1 Protein by Gene Targeting Leads to a Defect in Thymus Development and a Delay in Friend Virus-Induced Erythroleukemia

1996 • 112 citations

The Drosophila E74 gene is required for the proper stageand tissue-specific transcription of ecdysone-regulated genes at the onset of metamorphosis

1995 • 111 citations

DNA binding specificities of Spi-1/PU.1 and Spi-B transcription factors and identification of a Spi-1/Spi-B binding site in the c-fes/c-fps promoter.

1995 • 111 citations

The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation

1995 • 108 citations

Theetsmultigene family is conserved throughout the Metazoa

1993 • 108 citations

FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements

1997 • 107 citations

The Ets family of proteins: weak modulators of gene expression in quest for transcriptional partners.

1994 • 104 citations

Solution structure of the ets domain of Fli-1 when bound to DNA

1994 • 103 citations

Functional dissection of the transcription factor Elk-1.

1994 • 90 citations

SAP1a is a nuclear target of signaling cascades involving ERKs.

1995 • 86 citations

Characterization of NERF, a Novel Transcription Factor Related to the Ets Factor ELF-1

1996 • 86 citations

The ETS-domain transcription factors Elk-1 and SAP-1 exhibit differential DNA binding specifitoies

1995 • 83 citations

Determinants of DNA-Binding Specificity of ETS-Domain Transcription Factors

1996 • 82 citations

The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA.

1996 • 82 citations

New Insights on DNA Recognition by ets Proteins from the Crystal Structure of the PU.1 ETS Domain-DNA Complex

1996 • 80 citations

Molecular characterization of the ets-related human transcription factor ER81.

1995 • 77 citations

Mesodermal expression of the chicken erg gene associated with precartilaginous condensation and cartilage differentiation

1995 • 76 citations

Neither erk nor jnk/sapk map kinase subtypes are essential for histone h3/hmg-14 phosphorylation or c-fos and c-jun induction

1995 • 74 citations

Molecular characterization of the B-box protein-protein interaction motif of the ETS-domain transcription factor Elk-1

1997 • 73 citations

MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties.

1996 • 71 citations

Structural coupling of the inhibitory regions flanking the ETS domain of murine Ets‐1

1996 • 66 citations

Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancer.

1994 • 65 citations

Evolution of the ets Gene Family

1993 • 63 citations

Phosphorylation-Dependent Formation of a Quaternary Complex at the c-fos SRE

1996 • 62 citations

A Potential Role for Elf-1 in Terminal Transferase Gene Regulation

1996 • 59 citations

A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74

1993 • 55 citations

Elk-1 Can Recruit SRF to Form a Ternary Complex Upon the Serum Response Element

1996 • 53 citations

ERM, a PEA3 Subfamily of Ets Transcription Factors, Can Cooperate with c-Jun

1995 • 52 citations

Characterization of the Elk-1 ETS DNA-binding Domain

1995 • 52 citations

Differential phosphorylations of Spi-B and Spi-1 transcription factors.

1996 • 51 citations

SRE elements are binding sites for the fusion protein EWS-FLI-1

1996 • 49 citations

Two functionally distinct domains responsible for transactivation by the Ets family member ERM.

1996 • 46 citations

ERK2/p42 MAP kinase stimulates both autonomous and SRF‐dependent DNA binding by Elk‐1

1995 • 43 citations

Expression of the transcription factor c-Ets1 correlates with the occurrence of invasive processes during normal and pathological development.

1994 • 42 citations

Importance of low affinity Elf-1 sites in the regulation of lymphoid-specific inducible gene expression.

1996 • 33 citations

Cloning and expression of the murine Elf-1 cDNA

1996 • 29 citations

Phosphorylation of Ets1 regulates the complementation of a CSF-1 receptor impaired in mitogenesis.

1996 • 28 citations

Overexpression of the Xenopus Xl-fli gene during early embryogenesis leads to anomalies in head and heart development and erythroid differentiation.

1996 • 27 citations

Requirement of the ETS domain transcription factor D-ELG for egg chamber patterning and development during Drosophila oogenesis.

1995 • 9 citations

Structure and organization of the mouse elk1 gene

1996 • 7 citations