The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions

Cancer Statistics, 2003

2003 • 3,302 citations

The ETS-domain transcription factor family

2001 • 1,033 citations

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG

1994 • 727 citations

Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.

1992 • 338 citations

Transcriptional Control of Matrix Metalloproteinases and the Tissue Inhibitors of Matrix Metalloproteinases

1997 • 332 citations

ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin ?3

1999 • 210 citations

High levels of MMP-2, MMP-9, MT1-MMP and TIMP-2 mRNA correlate with poor survival in ovarian carcinoma.

1999 • 177 citations

The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

2000 • 164 citations

The erg gene: a human gene related to the ets oncogene.

1987 • 164 citations

Complete one-hour immunocytochemistry based on capillary action.

1992 • 156 citations

HER2/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer

1997 • 152 citations

EMMPRIN (extracellular matrix metalloproteinase inducer) is a novel marker of poor outcome in serous ovarian carcinoma.

2003 • 140 citations

Erg, an Ets-family member, differentially regulates human collagenase1 (MMP1) and stromelysin1 (MMP3) gene expression by physically interacting with the Fos/Jun complex.

1996 • 139 citations

When Ets transcription factors meet their partners

2002 • 137 citations

Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters.

1995 • 128 citations

The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis

2001 • 127 citations

Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals.

1995 • 116 citations

Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias

1997 • 115 citations

Binding of an Interferon-inducible Protein (p202) to the Retinoblastoma Protein

1995 • 110 citations

Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors.

1994 • 108 citations

E-cadherin and ?-, ?-, and ?-catenin protein expression is up-regulated in ovarian carcinoma cells in serous effusions

2000 • 102 citations

Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies

1999 • 101 citations

Ets-1 messenger RNA expression is a novel marker of poor survival in ovarian carcinoma.

2001 • 93 citations

Expression of the PEA3 group of ETS-related transcription factors in human breast-cancer cells

1997 • 91 citations

Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of theetsoncogene family

1993 • 85 citations

Elucidation of a signaling pathway induced by FGF-2 leading to uPA gene expression in NIH 3T3 fibroblasts.

1995 • 82 citations

PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas.

1993 • 80 citations

Expression of urokinase plasminogen activator and receptor in conjunction with the ets family and AP-1 complex transcription factors in high grade prostate cancers

2001 • 79 citations

Molecular characterization of the ets-related human transcription factor ER81.

1995 • 77 citations

αV- and β1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients

2003 • 75 citations

Involvement of a Mitogen-activated Protein Kinase Signaling Pathway in the Regulation of Urokinase Promoter Activity by c-Ha-ras

1995 • 72 citations

Ovarian carcinoma cells in serous effusions show altered MMP-2 and TIMP-2 mRNA levels

2001 • 67 citations

Carbohydrate antigen expression in primary tumors, metastatic lesions, and serous effusions from patients diagnosed with epithelial ovarian carcinoma: Evidence of up-regulated Tn and Sialyl Tn antigen expression in effusions

2000 • 66 citations

Expression of Membrane-Type 1, 2, and 3 Matrix Metalloproteinases Messenger RNA in Ovarian Carcinoma Cells in Serous Effusions

2001 • 57 citations

Antisense E1AF transfection restrains oral cancer invasion by reducing matrix metalloproteinase activities.

1997 • 56 citations

Expression of E1AF/PEA3, an Ets-related transcription factor in human non-small-cell lung cancers: Its relevance in cell motility and invasion

2001 • 54 citations

Pleural effusion in breast cancer: a review of the Nottingham experience.

1994 • 54 citations

Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions.

2002 • 50 citations

β₃A-Integrin Downregulates the Urokinase-Type Plasminogen Activator Receptor (u-PAR) through aPEA3/ets Transcriptional Silencing Element in the u-PAR Promoter

2001 • 49 citations

Alphav integrin expression is a novel marker of poor prognosis in advanced-stage ovarian carcinoma.

2001 • 46 citations

Effusion cytology in ovarian cancer: new molecular methods as aids to diagnosis and prognosis

2003 • 46 citations

Ets-1 mRNA Expression in Effusions of Serous Ovarian Carcinoma Patients Is a Marker of Poor Outcome

2001 • 45 citations

PEA3 and AP-1 Are Required for Constitutive IL-8 Gene Expression in Hepatoma Cells

2000 • 45 citations

PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma.

2003 • 44 citations

Expression of E1AF, an ets-family transcription factor, is correlated with the invasive phenotype of oral squamous cell carcinoma

1997 • 44 citations

Expression of Various Matrix Proteases and Ets Family Transcriptional Factors in Ovarian Cancer Cell Lines: Correlation to Invasive Potential

2000 • 38 citations

Multivariate analysis of prognostic features in malignant pleural effusions from breast cancer patients.

1994 • 32 citations

Altered expression of Erg and Ets-2 transcription factors is associated with genetic changes at 21q22.2-22.3 in immortal and cervical carcinoma cell lines

1997 • 31 citations

Expression of ets-1 and ets-2 in colonic neoplasms.

2002 • 29 citations

Expression of the 67 kDa laminin receptor and the alpha6 integrin subunit in serous ovarian carcinoma.

2003 • 29 citations

Binding sites of HeLa cell nuclear proteins on the upstream region of adenovirus type 5 E1A gene

1989 • 28 citations

Expression of angiogenesis-related genes in ovarian carcinoma--a clinicopathologic study.

2000 • 24 citations

Clinical significance of PEA3 in human breast cancer

2002 • 22 citations

Signaling molecules implicated in heregulin induction of growth arrest and apoptosis

2001 • 18 citations

Linkage of elevated ets-2 expression to hepatocarcinogenesis.

2002 • 7 citations