The genetics of bipolar disorder: genome ‘hot regions,’ genes, new potential candidates and future directions

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

2007 • 9,332 citations

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

1998 • 1,915 citations

Hippocampal atrophy in recurrent major depression.

1996 • 1,884 citations

Neuregulin 1 and Susceptibility to Schizophrenia

2002 • 1,654 citations

Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform

2003 • 1,478 citations

The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression

2003 • 1,188 citations

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia

2003 • 1,160 citations

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

1998 • 867 citations

Genetic and physiological data implicating the new human gene G72 and the gene for <scp>d</scp> -amino acid oxidase in schizophrenia

2002 • 828 citations

Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia

2002 • 824 citations

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder

2007 • 699 citations

A unique central tryptophan hydroxylase isoform

2003 • 694 citations

The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study

2002 • 604 citations

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder

2003 • 573 citations

Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus

2002 • 570 citations

Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

2003 • 517 citations

Disrupted in Schizophrenia 1 (DISC1): Association with Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder

2004 • 437 citations

Toward Constructing an Endophenotype Strategy for Bipolar Disorders

2006 • 423 citations

A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior

2003 • 417 citations

Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia

2004 • 410 citations

A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2

1999 • 399 citations

Molecular cloning of a human gene that is a member of the nerve growth factor family.

1990 • 397 citations

Bipolar I Disorder and Schizophrenia: A 440–Single-Nucleotide Polymorphism Screen of 64 Candidate Genes among Ashkenazi Jewish Case-Parent Trios

2005 • 396 citations

Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia

2004 • 389 citations

Isoform-specific expression and function of neuregulin

1997 • 384 citations

Glycogen synthase kinase-3: functions in oncogenesis and development

1992 • 379 citations

A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3

1994 • 320 citations

Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder

2004 • 313 citations

Evidence for a Relationship Between Genetic Variants at the Brain-Derived Neurotrophic Factor (BDNF) Locus and Major Depression

2005 • 311 citations

Individual and Familial Risk Factors for Bipolar Affective Disorders in Denmark

2003 • 304 citations

Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia

2005 • 291 citations

Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder

2006 • 288 citations

A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22

2001 • 278 citations

Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder

2003 • 272 citations

A locus for bipolar affective disorder on chromosome 4p

1996 • 272 citations

A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders

2003 • 272 citations

Polymorphisms at the G72/G30 Gene Locus, on 13q33, Are Associated with Bipolar Disorder in Two Independent Pedigree Series*

2003 • 270 citations

BDNF gene is a risk factor for schizophrenia in a Scottish population

2005 • 265 citations

Neuregulin-β induces expression of an NMDA-receptor subunit

1997 • 261 citations

Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23

1996 • 260 citations

Meta‐analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders

2004 • 256 citations

Molecular Cloning of a Novel Putative Ca2+Channel Protein (TRPC7) Highly Expressed in Brain

1998 • 255 citations

Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders

1998 • 248 citations

Operation of the Schizophrenia Susceptibility Gene, Neuregulin 1, Across Traditional Diagnostic Boundaries to Increase Risk for Bipolar Disorder

2005 • 246 citations

Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q

2005 • 246 citations

Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24

1999 • 221 citations

Initial genome scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 1, 6, 8, 10, and 12

1997 • 218 citations

Serotonin Transporter Gene Variants and Behavior: A Comprehensive Review

2006 • 218 citations

Genomewide Linkage Analyses of Bipolar Disorder: A New Sample of 250 Pedigrees from the National Institute of Mental Health Genetics Initiative

2003 • 214 citations

Association Between the Tryptophan Hydroxylase Gene and Manic-depressive Illness

1998 • 206 citations

Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder

2006 • 194 citations

Linkage Disequilibrium of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype

2004 • 190 citations

Genomewide Linkage Scan in Schizoaffective Disorder

2005 • 188 citations

Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the ?7-nicotinic acetylcholine receptor subunit gene (CHRNA7)

2001 • 185 citations

Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population

2005 • 184 citations

Linkage analysis of psychosis in bipolar pedigrees suggests novel putative loci for bipolar disorder and shared susceptibility with schizophrenia

2004 • 177 citations

Genomewide Linkage Analysis of Bipolar Disorder by Use of a High-Density Single-Nucleotide–Polymorphism (SNP) Genotyping Assay: A Comparison with Microsatellite Marker Assays and Finding of Significant Linkage to Chromosome 6q22

2004 • 173 citations

A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish

1996 • 173 citations

Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 3, 5, 15, 16, 17, and 22

1997 • 165 citations

COMT: A common susceptibility gene in bipolar disorder and schizophrenia

2004 • 165 citations

A single nucleotide polymorphism in glycogen synthase kinase 3-β promoter gene influences onset of illness in patients affected by bipolar disorder

2003 • 163 citations

Catechol O-Methyltransferase, Serotonin Transporter, and Tryptophan Hydroxylase Gene Polymorphisms in Bipolar Disorder Patients With and Without Comorbid Panic Disorder

2002 • 161 citations

HTR2A Gene Variants and Psychiatric Disorders: A Review of Current Literature and Selection of SNPs for Future Studies

2007 • 159 citations

Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder

2001 • 159 citations

The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: A meta-analysis

2005 • 156 citations

Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis

2005 • 156 citations

Variation at the DAOA/G30 Locus Influences Susceptibility to Major Mood Episodes but Not Psychosis in Schizophrenia and Bipolar Disorder

2006 • 152 citations

Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q

2003 • 152 citations

The neuregulin, glial growth factor 2, diminishes autoimmune demyelination and enhances remyelination in a chronic relapsing model for multiple sclerosis

1998 • 152 citations

Family-based association of FKBP5 in bipolar disorder

2008 • 150 citations

Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder

2006 • 149 citations

Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation

2006 • 149 citations

Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder

2001 • 146 citations

Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12

2003 • 143 citations

An insertion/deletion polymorphism in the angiotensin converting enzyme gene is associated with both brain substance P contents and affective disorders

1996 • 142 citations

Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree.

1995 • 142 citations

Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder

2003 • 142 citations

Confirmation of association between the Val66Met polymorphism in the brain‐derived neurotrophic factor (BDNF) gene and bipolar I disorder

2005 • 140 citations

An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients

2003 • 140 citations

A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q

2001 • 139 citations

Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder

2005 • 138 citations

Association Between Bipolar Disorder and Monoamine Oxidase A Gene Polymorphisms: Results of a Multicenter Study

2000 • 137 citations

Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder

2007 • 134 citations

Psychologically Stressful Events in the Precipitation of Manic Episodes

1979 • 134 citations

Initial Genome Scan of the NIMH Genetics Initiative Bipolar Pedigrees: Chromosomes 4, 7, 9, 18, 19, 20, and 21q

1997 • 133 citations

N-methyl-d-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels

2006 • 132 citations

COMT genetic variation confers risk for psychotic and affective disorders: a case control study

2005 • 132 citations

Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33

2003 • 131 citations

Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent samples

2005 • 131 citations

A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22–21, 4p16, 6q14–22, 10q26 and 16p13.3

2002 • 130 citations

Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families

1999 • 129 citations

Increase in GSK3β gene copy number variation in bipolar disorder

2007 • 128 citations

Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder

2001 • 127 citations

Evidence for a role of phospholipase C-γ1 in the pathogenesis of bipolar disorder

1998 • 127 citations

Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population

2006 • 124 citations

Evidence for a putative bipolar disorder locus on 2p13–16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21–24, 13q32, 14q21 and 17q11–12

2003 • 124 citations

Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder

2007 • 122 citations

NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences

2007 • 121 citations

Association of Brain-Specific Tryptophan Hydroxylase, TPH2, With Unipolar and Bipolar Disorder in a Northern Swedish, Isolated Population

2006 • 115 citations

Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder

2003 • 115 citations

Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor

2004 • 113 citations

Association study of brain‐derived neurotrophic factor in adults with a history of childhood onset mood disorder

2004 • 112 citations

A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders

1999 • 112 citations

Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder

2006 • 112 citations

A Comprehensive Linkage Analysis of Chromosome 21q22 Supports Prior Evidence for a Putative Bipolar Affective Disorder Locus

1999 • 110 citations

Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders

1996 • 108 citations

Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder

2006 • 108 citations

Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder

2003 • 107 citations

No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene

1997 • 105 citations

A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42

2004 • 104 citations

Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: Chromosomes 2, 11, 13, 14, and X

1997 • 104 citations

Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter

1999 • 103 citations

Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)

2005 • 103 citations

Molecular genetics of bipolar disorder

2005 • 102 citations

Association analysis of the functional monoamine oxidase a gene promoter polymorphism in psychiatric disorders

2001 • 100 citations

C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies

2006 • 100 citations

Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder

2004 • 100 citations

No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: A multicenter study

2004 • 100 citations

Allelic association of G72/G30 with schizophrenia and bipolar disorder: A comprehensive meta-analysis

2007 • 99 citations

Nested Association Between Genetic Variation in Tryptophan Hydroxylase II, Bipolar Affective Disorder, and Suicide Attempts

2006 • 99 citations

Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder

2005 • 97 citations

No Evidence for an Association of Polymorphisms of the Tryptophan Hydroxylase Gene With Affective Disorders or Attempted Suicide Among Japanese Patients

1999 • 97 citations

A Susceptibility Locus for Bipolar Affective Disorder on Chromosome 4q35

1998 • 96 citations

Genomewide Linkage Scan for Bipolar-Disorder Susceptibility Loci among Ashkenazi Jewish Families

2004 • 95 citations

Two-Locus Admixture Linkage Analysis of Bipolar and Unipolar Affective Disorder Supports the Presence of Susceptibility Loci on Chromosomes 11p15 and 21q22

1997 • 93 citations

Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3

2005 • 92 citations

Catechol-O-methyltransferase Vall58Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder

1997 • 91 citations

COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance

2007 • 90 citations

Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disorders

2004 • 86 citations

No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder.

1998 • 85 citations

Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees

2003 • 85 citations

Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder

2003 • 83 citations

Genetic Association Analysis of Serotonin System Genes in Bipolar Affective Disorder

1999 • 83 citations

Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder

2003 • 81 citations

Association of AKT1 haplotype with the risk of schizophrenia in Iranian population

2006 • 81 citations

Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees

2000 • 80 citations

Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene

1998 • 79 citations

Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes

1996 • 76 citations

Association study of CHRFAM7A copy number and 2bp deletion polymorphisms with schizophrenia and bipolar affective disorder

2006 • 76 citations

Full-Genome Scan for Linkage in 50 Families Segregating the Bipolar Affective Disease Phenotype

2000 • 76 citations

Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex

1992 • 76 citations

Three Potential Susceptibility Loci Shown by a Genome-Wide Scan for Regions Influencing the Age at Onset of Mania

2004 • 76 citations

Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder

2006 • 75 citations

Insertion/deletion variant (−141C Ins/Del) in the 5′ regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder

1998 • 75 citations

Investigation of the human serotonin 6 (5-HT6) receptor gene in bipolar affective disorder and schizophrenia

2000 • 74 citations

A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity

2006 • 74 citations

Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14

2006 • 74 citations

Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder

1992 • 74 citations

Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees

2002 • 74 citations

Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder

1997 • 74 citations

Identification of PIK3C3 promoter variant associated with bipolar disorder and schizophrenia

2004 • 73 citations

The Wellcome trust UK–Irish bipolar affective disorder sibling-pair genome screen: first stage report

2002 • 72 citations

A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes 9, 13 and 19

2002 • 72 citations

Differential Expression of Disrupted-in-Schizophrenia (DISC1) in Bipolar Disorder

2006 • 70 citations

Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study

2001 • 70 citations

Systematic screening for mutations in the 5′-regulatory region of the human dopamine D1 receptor (DRD1) gene in patients with schizophrenia and bipolar affective disorder

1996 • 70 citations

Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.

1996 • 69 citations

No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder

1998 • 69 citations

Detection of four polymorphic sites in the human dopamine D1 receptor gene (DRD1)

1994 • 68 citations

Family-Based Association Study of Lithium-Related and Other Candidate Genes in Bipolar Disorder

2008 • 68 citations

Genetic analysis of a functional GRIN2A promoter (GT)n repeat in bipolar disorder pedigrees in humans

2003 • 68 citations

Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3)

1998 • 67 citations

5-HT1A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies

2007 • 67 citations

Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees

2002 • 67 citations

Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals

2004 • 66 citations

Systematic screening for mutations in the promoter and the coding region of the 5‐HT_1A gene

1995 • 66 citations

5-HT2A receptor gene promoter polymorphism –1438A/G and bipolar disorder

2001 • 65 citations

Association of 5-HT2A receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk

2002 • 64 citations

The phospholipase C-γ1 gene (PLCG1) and lithium-responsive bipolar disorder: re-examination of an intronic dinucleotide repeat polymorphism

2001 • 64 citations

Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia

2005 • 63 citations

Family‐based association study of 5‐HTTLPR, TPH, MAO‐A, and DRD4 polymorphisms in mood disorders

2002 • 63 citations

Dopamine Receptor D&lt;sub&gt;1&lt;/sub&gt; Gene –48A/G Polymorphism Is Associated with Bipolar Illness but Not with Schizophrenia in a Polish Population

2006 • 62 citations

Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11

1994 • 62 citations

Linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder: Extending the transmission disequilibrium test (TDT) to examine genetic heterogeneity

1997 • 62 citations

Stage 2 of the Wellcome Trust UK–Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16–q21, 4q12–q21, 9p21, 10p14–p12 and 18q22

2005 • 62 citations

Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele

2006 • 62 citations

Close linkage of bipolar disorder to chromosome 11 markers is excluded in two large Australian pedigrees

1991 • 61 citations

Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients.

2001 • 61 citations

Association and linkage analysis of RGS4 polymorphisms with schizophrenia and bipolar disorder in Brazil

2004 • 61 citations

Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4

2002 • 60 citations

PP2A-Bγ subunit and KCNQ2 K+ channels in bipolar disorder

2006 • 60 citations

Association Analysis of the &lt;i&gt;GSK-3&lt;/i&gt;β T–50C Gene Polymorphism with Schizophrenia and Bipolar Disorder

2006 • 59 citations

Is the 5‐HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients?

2007 • 59 citations

Analysis and metaanalysis of two polymorphisms within the tyrosine hydroxylase gene in bipolar and unipolar affective disorders

1999 • 57 citations

Candidate gene analysis of 21q22: Support for S100B as a susceptibility gene for bipolar affective disorder with psychosis

2007 • 57 citations

A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes 9, 13 and 19

2002 • 57 citations

Analysis of chromosome 18 DNA markers in multiplex pedigrees with manic depression

1996 • 57 citations

Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees

2004 • 57 citations

Association analysis between dopamine receptor genes and bipolar affective disorder

1999 • 57 citations

Association of DAO and G72(DAOA)/G30 genes with bipolar affective disorder

2007 • 56 citations

Association between the GABAA receptor ?5 subunit gene locus (GABRA5) and bipolar affective disorder

1998 • 56 citations

Excess of allele1 for α3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study

2002 • 56 citations

Genomewide Scan and Fine-Mapping Linkage Studies in Four European Samples with Bipolar Affective Disorder Suggest a New Susceptibility Locus on Chromosome 1p35-p36 and Provides Further Evidence of Loci on Chromosome 4q31 and 6q24

2005 • 56 citations

Association of the Dysbindin Gene With Bipolar Affective Disorder

2006 • 56 citations

Association analysis between mood disorder and monoamine oxidase gene

2000 • 55 citations

Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European multicenter association study of affective disorders

2002 • 55 citations

5-HT2A receptor and bipolar affective disorder: association studies in affected patients

1997 • 55 citations

No association of two common SNPs at position −1727 A/T, −50 C/T of GSK-3 beta polymorphisms with schizophrenia and bipolar disorder of Korean population

2005 • 55 citations

Angiotensinogen and angiotensin converting enzyme gene polymorphisms and the risk of bipolar affective disorder in humans

2000 • 55 citations

Association study of the human partially duplicated α7 nicotinic acetylcholine receptor genetic variant with bipolar disorder

2003 • 55 citations

A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25–q26

2001 • 54 citations

Mutational screening and association study of glutamate decarboxylase 1 as a candidate susceptibility gene for bipolar affective disorder and schizophrenia

2005 • 54 citations

Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients

2004 • 53 citations

Tryptophan hydroxylase gene and major psychoses

2001 • 53 citations

Absence of linkage between chromosome 11p15 markers and manic- depressive illness in a Belgian pedigree

1991 • 53 citations

Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: An association study

2007 • 52 citations

MLC1 Gene Is Associated with Schizophrenia and Bipolar Disorder in Southern India

2005 • 52 citations

Polymorphisms in the neuronal isoform of tryptophan hydroxylase 2 are associated with bipolar disorder in French Canadian pedigrees

2006 • 51 citations

Linkage Analysis of a Complex Pedigree with Severe Bipolar Disorder, Using a Markov Chain Monte Carlo Method

2001 • 50 citations

Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder

1997 • 49 citations

A follow-up linkage study supports evidence for a bipolar affective disorder locus on chromosome 21q22

2001 • 49 citations

Assessment of the Effect of Age at Onset on Linkage to Bipolar Disorder: Evidence on Chromosomes 18p and 21q

2005 • 48 citations

Polymorphisms in wolframin (WFS1) gene are possibly related to increased risk for mood disorders

2005 • 48 citations

A48G polymorphism in the D₁ receptor genes associated with bipolar I disorder

2005 • 48 citations

Polymorphism of the gene of angiotensin converting enzyme: lack of association with mood disorder

2000 • 48 citations

Genome-wide scan supports the existence of a susceptibility locus for schizophrenia and bipolar disorder on chromosome 15q26

2006 • 47 citations

Genome wide scan using homozygosity mapping and linkage analyses of a single pedigree with affective disorder suggests oligogenic inheritance

2003 • 47 citations

No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover

2007 • 47 citations

Family-based association study between bipolar disorder andDRD2, DRD4, DAT, andSERT in Sardinia

1999 • 47 citations

The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder.

1996 • 47 citations

Polymorphism Screening of PIP5K2A: A Candidate Gene for Chromosome 10p‐Linked Psychiatric Disorders

2003 • 46 citations

Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X

2003 • 46 citations

Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disorders

2003 • 46 citations

An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2–q11.2 in a large Turkish pedigree

2001 • 45 citations

Two novel variants in the DOPA decarboxylase gene: association with bipolar affective disorder

1999 • 45 citations

Association and linkage studies of candidate genes involved in GABAergic neurotransmission in lithium-responsive bipolar disorder.

2000 • 45 citations

Linkage disequilibrium between dopamine D1 receptor gene (DRD1) and bipolar disorder

2002 • 45 citations

MTHFD 1958G&gt;A and MTR 2756A&gt;G polymorphisms are associated with bipolar disorder and schizophrenia

2007 • 45 citations

Possible parent‐of‐origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder

2002 • 44 citations

Genome‐wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: Fine mapping adds support on chromosomes 6 and 11

2004 • 44 citations

Genetic variation of the 5-HT 2A receptor gene and bipolar affective disorder

1997 • 44 citations

A rare coding variant within the wolframin gene in bipolar and unipolar affective disorder cases

1999 • 44 citations

Association of the trace amine associated receptor 6 (TAAR6) gene with schizophrenia and bipolar disorder in a Korean case control sample

2006 • 44 citations

Exclusion of close linkage of bipolar disorder to dopamine D1 and D2 receptor gene markers

1992 • 43 citations

The GABA type A receptor α5 subunit gene is associated with bipolar I disorder

2005 • 43 citations

No association of an insertion/deletion polymorphism in the angiotensin I converting enzyme gene with bipolar or unipolar affective disorders

2000 • 42 citations

Mutation screening of the Wolfram syndrome gene in psychiatric patients

2000 • 42 citations

Genetic linkage study of bipolar disorder and the serotonin transporter

1996 • 42 citations

Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis

2004 • 42 citations

Dopamine transporter gene (DAT1) VNTR polymorphism in major psychiatric disorders: family‐based association study in the Bulgarian population

2002 • 41 citations

No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene

1997 • 41 citations

Nonparametric simulation-based statistical analyses for bipolar affective disorder locus on chromosome 21q22.3

1999 • 40 citations

Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population

2005 • 40 citations

Linkage and association between serotonin 2A receptor gene polymorphisms and bipolar I disorder

2003 • 40 citations

No association of a functional polymorphism in the dopamine D2 receptor promoter region with bipolar or unipolar affective disorders

1998 • 40 citations

The Breakpoint Cluster Region Gene on Chromosome 22q11 is Associated with Bipolar Disorder

2005 • 39 citations

Genome scan of the fifty‐six bipolar pedigrees from the NIMH genetics initiative replication sample: Chromosomes 4, 7, 9, 18, 19, 20, and 21

2003 • 39 citations

Genome‐wide scan of bipolar disorder and investigation of population stratification effects on linkage: Support for susceptibility loci at 4q21, 7q36, 9p21, 12q24, 14q24, and 16p13

2007 • 39 citations

A Promoter Haplotype of the Inositol Monophosphatase 2 Gene (IMPA2) at 18p11.2 Confers a Possible Risk for Bipolar Disorder by Enhancing Transcription

2007 • 39 citations

WFS1 gene mutation search in depressive patients: detection of five missense polymorphisms but no association with depression or bipolar affective disorder

2000 • 38 citations

Mutational analysis of the Wolfram syndrome gene in two families with chromosome 4p-linked bipolar affective disorder

2000 • 38 citations

Association analysis of the dopamine transporter (DAT1)‐67A/T polymorphism in bipolar disorder

2005 • 37 citations

Analysis of the pseudoautosomal X-linked geneSYBL1in bipolar affective disorder: Description of a new candidate allele for psychiatric disorders

2000 • 37 citations

Tumour necrosis factor α and bipolar affective puerperal psychosis

2000 • 37 citations

Effect of 5‐haplotype of dysbindin gene (DTNBP1) polymorphisms for the susceptibility to bipolar I disorder

2006 • 36 citations

Further tests for linkage of bipolar affective disorder to the tyrosine hydroxylase gene locus on chromosome 11p15 in a new series of multiplex British affective disorder pedigrees [published erratum appears in Am J Psychiatry 1997 Jan;154(1):139]

1996 • 36 citations

Polymorphism in the promoter region of the α2A adrenergic receptor gene and mood disorders

1998 • 36 citations

Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region

2005 • 36 citations

Additional, physically ordered markers increase linkage signal for bipolar disorder on chromosome 18q22

2003 • 35 citations

Early onset bipolar disorder: possible linkage to chromosome 9q34

2006 • 35 citations

Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates

2007 • 35 citations

Association study of myo-inositol monophosphatase 2 (IMPA2) polymorphisms with bipolar affective disorder and response to lithium treatment

2004 • 35 citations

Lack of association between bipolar disorder and tyrosine hydroxylase

1997 • 35 citations

Fine mapping supports previous linkage evidence for a bipolar disorder susceptibility locus on 13q32

2001 • 35 citations

Analysis of a cluster of polymorphisms in AKT1 gene in bipolar pedigrees: a family-based association study

2003 • 34 citations

No evidence for association of dopamine D2 receptor variant (Ser 311/Cys311) with major psychosis

1996 • 34 citations

Bipolar disorder and variation at a common polymorphism (A1832G) within exon 8 of the Wolfram gene

2000 • 34 citations

Association study of bipolar disorder using a functional polymorphism (Ser311→Cys) in the dopamine D2 receptor gene

1995 • 34 citations

Distribution of 1298A &gt; C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia

2007 • 34 citations

A meta-analysis of chromosome 18 linkage data for bipolar illness

1997 • 33 citations

Dysbindin gene variants are associated with bipolar I disorder in a Korean population

2007 • 33 citations

Linkage of mood disorders with D2, D3 and TH genes: a multicenter study

2000 • 33 citations

Rare variants of the gene encoding the potassium chloride co-transporter 3 are associated with bipolar disorder

2005 • 33 citations

Catechol-O-methyltransferase gene variants in mood disorders in the Italian population

2006 • 33 citations

Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder

2002 • 32 citations

No association between particular DRD3 and DAT gene polymorphisms and manic-depressive illness in a Spanish sample

1996 • 32 citations

Association between a polymorphism in the pseudoautosomal X‐linked gene SYBL1 and bipolar affective disorder

2001 • 32 citations

Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders

2003 • 32 citations

Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series

2003 • 31 citations

X-box binding protein 1 (XBP1) C−116G polymorphisms in bipolar disorders and age of onset

2004 • 31 citations

Genetic mapping using haplotype and model‐free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31‐33

2003 • 31 citations

Analysis of genome-wide CAG/CTG repeats, and at SEF2-1B and ERDA1 in schizophrenia and bipolar affective disorder

1999 • 30 citations

Association analysis of the 5-HT6 receptor polymorphism (C267T) in mood disorders

1999 • 30 citations

SYNGR1 is associated with schizophrenia and bipolar disorder in southern India

2005 • 30 citations

Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1)and association with bipolar affective disorder in Taiwan

2005 • 30 citations

Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate^,

2006 • 29 citations

Association analysis of the glycogen synthase kinase-3β gene in bipolar disorder

2005 • 29 citations

No association between dopamine D1, D2, and D3 receptor genes and manic–depressive illness

1998 • 29 citations

Lack of association between polymorphisms of dopamine receptors, type D2, and bipolar affective illness in a Polish population.

2005 • 28 citations

Tumor necrosis factor‐α gene polymorphism at position −308 and schizophrenia in the Korean population

2003 • 28 citations

Association of a new polymorphism in ALOX12 gene with bipolar disorder

2003 • 28 citations

Allelic variation of a BalI polymorphism in the DRD3 gene does not influence susceptibility to bipolar disorder: Results of analysis and meta‐analysis

2001 • 28 citations

Further evidence of MAO‐A gene variants associated with bipolar disorder

2006 • 28 citations

No evidence for association between 19 cholinergic genes and bipolar disorder

2007 • 27 citations

Haplotype Analysis and a Novel Allele-Sharing Method Refines a Chromosome 4p Locus Linked to Bipolar Affective Disorder

2006 • 27 citations

Analysis of new D4 dopamine receptor (DRD4) coding region variants and TH microsatellite in the Old Order Amish family (OOA110)

1994 • 27 citations

Association Studies of Candidate Genes in Bipolar Disorders

2000 • 27 citations

Lack of association between 5HT_2A receptor gene haplotype, bipolar disorder and its clinical subtypes in a West European sample

2004 • 27 citations

Linkage Analysis of the D1 Dopamine Receptor Gene and Manic Depression in Six Families

1992 • 26 citations

Identification of a potential Bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4

2005 • 26 citations

Polymorphism screening of PIK4CA: Possible candidate gene for chromosome 22q11‐linked psychiatric disorders

2002 • 26 citations

No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humans

2003 • 26 citations

Bipolar disorder susceptibility region on Xq24–q27.1 in Finnish families

2002 • 26 citations

European combined analysis of the CTG18.1 and the ERDA1 CAG/CTG repeats in bipolar disorder

2002 • 26 citations

No association between the tyrosine hydroxylase microsatellite marker HUMTH01 and schizophrenia or bipolar I disorder

1998 • 25 citations

Polymorphisms in the homeobox gene OTX2 may be a risk factor for bipolar disorder

2007 • 25 citations

A genome‐wide search for risk genes using homozygosity mapping and microarrays with 1,494 single‐nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder

2004 • 25 citations

Association study between novel promoter variants at the 5-HT2C receptor gene and human patients with bipolar affective disorder

2001 • 25 citations

Genetic linkage analysis of manic depression in Iceland.

1993 • 25 citations

Linkage disequilibrium analyses in the Costa Rican population suggests discrete gene loci for schizophrenia at 8p23.1 and 8q13.3

2006 • 23 citations

Linkage and candidate gene analysis of 14q22-24 in bipolar disorder: support for GCHI as a novel susceptibility gene

2005 • 23 citations

Chromosome 10q harbors a susceptibility locus for bipolar disorder in Ashkenazi Jewish families

2007 • 23 citations

Analysis of Synapsin III –196 Promoter Mutation in Schizophrenia and Bipolar Disorder

2006 • 23 citations

Genetic variations in the WFS1 gene in Japanese with type 2 diabetes and bipolar disorder

2004 • 22 citations

Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia

2006 • 22 citations

Linkage studies in bipolar affective disorder with markers on chromosome 21

1996 • 22 citations

Linkage studies of bipolar disorder with chromosome 18 markers

1999 • 21 citations

Identification of two risk haplotypes for schizophrenia and bipolar disorder in the synaptic vesicle monoamine transporter gene (SVMT)

2007 • 21 citations

Genetic linkage analysis of bipolar affective disorder in an Old Order Amish pedigree

1992 • 21 citations

Genetic refinement and physical mapping of a 2.3 Mb probable disease region associated with a bipolar affective disorder susceptibility locus on chromosome 4q35

2002 • 21 citations

Association study between two variants in the DOPA decarboxylase gene in bipolar and unipolar affective disorder

2002 • 20 citations

Manic Depressive Illness and Tyrosine Hydroxylase Gene: Linkage Heterogeneity and Association

1997 • 19 citations

Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar affective disorder: A multicenter association study

1999 • 19 citations

Evidence for linkage by transmission disequilibrium test analysis of a chromosome 22 microsatellite marker D22S278 and bipolar disorder in a Palestinian Arab population

2000 • 19 citations

Interaction between the Tryptophan Hydroxylase Gene and the Serotonin Transporter Gene in Schizophrenia but Not in Bipolar or Unipolar Affective Disorders

2004 • 19 citations

Evolutionary conserved microsatellites in the promoter region of the 5-hydroxytryptamine receptor 2C gene ( HTR2C ) are not associated with bipolar disorder in females

2002 • 18 citations

Cloning and Expression of a cDNA Encoding the Human GABA-A Receptor α5 Subunit

1992 • 18 citations

Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder

2000 • 18 citations

Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder

2006 • 18 citations

SNP fine mapping of chromosome 8q24 in bipolar disorder

2007 • 18 citations

Gender dimorphism in the DAT1 − 67 T-allele homozygosity and predisposition to bipolar disorder

2007 • 18 citations

Gene‐based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: Association with HMG2L1 and TOM1

2007 • 18 citations

Association of MDR1 C3435T polymorphism with bipolar disorder in patients treated with valproic acid

2007 • 18 citations

CTG18.1 and ERDA-1 CAG/CTG Repeat Size in Bipolar Disorder

1999 • 17 citations

Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression

1994 • 17 citations

Association study of the tryptophan hydroxylase gene and bipolar affective disorder using family-based internal controls

2000 • 17 citations

Pseudoautosomal gene

1999 • 16 citations

Lack of association between manic-depressive illness and a highly polymorphic marker from GABRA3 gene

1995 • 16 citations

Family-Based Association Study of the Serotonin-2A Receptor Gene (5-HT2A) and Bipolar Disorder

2002 • 16 citations

Search for bipolar disorder susceptibility loci: The application of a modified genome scan concentrating on gene-rich regions

2000 • 15 citations

Suggestion of linkage between manic‐depressive illness and the enzyme phosphoglycolate phosphatase (PGP) on chromosome 16p

1993 • 15 citations

Identification of the Slynar Gene (AY070435) and Related Brain Expressed Sequences as a Candidate Gene for Susceptibility to Affective Disorders Through Allelic and Haplotypic Association With Bipolar Disorder on Chromosome 12q24

2006 • 14 citations

A linkage disequilibrium study of bipolar disorder and microsatellite markers on 22q13

2002 • 14 citations

Dense SNP association study for bipolar I disorder on chromosome 18p11 suggests two loci with excess paternal transmission

2002 • 14 citations

Molecular genetics of affective disorders

2004 • 13 citations

Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder

2006 • 13 citations

Manic-Depressive Illness and Linkage Reanalysis in the Xq27-Xq28 Region of Chromosome X

1995 • 13 citations

Genetic linkage study for bipolar disorders on chromosomes 17 and 18 in families with a high expression of mental illness from the Balearic Islands

2006 • 12 citations

Exclusion of Linkage Between Bipolar Affective Disorder and Chromosome 16 in 12 Australian Pedigrees

1997 • 11 citations

Association study of 5′‐UTR polymorphisms of the human dopamine transporter gene with manic depression

2006 • 11 citations

Screening of chromosomal region 21q22.3 for mutations in genes associated with neuronal Ca2+ signalling in bipolar affective disorder.

2006 • 11 citations

Absence of a significant linkage between Na⁺,K⁺‐ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old‐order Amish

2001 • 10 citations

Adjacent genetic markers on chromosome 11p15.5 at or near the tyrosine hydroxylase locus that show population linkage disequilibrium with each other do not show allelic association with bipolar affective disorder

1999 • 10 citations

Linkage analysis in bipolar pedigrees adds support for a susceptibility locus on 21q22

2004 • 10 citations

No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population

2006 • 10 citations

No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sample

2006 • 8 citations

No evidence of linkage between manic depressive illness and the dopa decarboxylase gene or nearby region on chromosome 7p

1995 • 6 citations

Association analysis of CHMP1.5 genetic variation and bipolar disorder

2005 • 4 citations

Affected-sib-pair analyses of bipolar disorder using data on chromosome 18

1997 • 3 citations