Stage 2 of the Wellcome Trust UK–Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16–q21, 4q12–q21, 9p21, 10p14–p12 and 18q22

Weighted kappa: Nominal scale agreement provision for scaled disagreement or partial credit.

1968 • 7,926 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

MANIC DEPRESSIVE ILLNESS

1984 • 3,013 citations

Parametric and nonparametric linkage analysis: a unified multipoint approach.

1996 • 2,905 citations

SCAN

1990 • 2,468 citations

PedCheck: A Program for Identification of Genotype Incompatibilities in Linkage Analysis

1998 • 2,089 citations

Manic-depressive illness

1991 • 1,538 citations

Construction of multilocus genetic linkage maps in humans.

1987 • 1,461 citations

Linkage strategies for genetically complex traits. I. Multilocus models.

1990 • 1,335 citations

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia

2003 • 1,160 citations

Complete multipoint sib-pair analysis of qualitative and quantitative traits.

1995 • 929 citations

Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia

2002 • 824 citations

A common mechanism of action for three mood-stabilizing drugs

2002 • 626 citations

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder

2003 • 573 citations

The genetics of schizophrenia and bipolar disorder: dissecting psychosis

2005 • 568 citations

Genetics of bipolar disorder

1999 • 529 citations

A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2

1999 • 399 citations

GRR: graphical representation of relationship errors

2001 • 398 citations

Asymptotic properties of affected-sib-pair linkage analysis.

1993 • 378 citations

Statistical Tests for Detection of Misspecified Relationships by Use of Genome-Screen Data

2000 • 337 citations

Accurate Inference of Relationships in Sib-Pair Linkage Studies

1997 • 287 citations

A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22

2001 • 278 citations

Genomewide Linkage Analyses of Bipolar Disorder: A New Sample of 250 Pedigrees from the National Institute of Mental Health Genetics Initiative

2003 • 214 citations

Evidence for shared susceptibility in bipolar disorder and schizophrenia

2003 • 196 citations

Suggestive Linkage to Chromosomal Regions 13q31 and 22q12 in Families With Psychotic Bipolar Disorder

2003 • 183 citations

Genomewide Linkage Analysis of Bipolar Disorder by Use of a High-Density Single-Nucleotide–Polymorphism (SNP) Genotyping Assay: A Comparison with Microsatellite Marker Assays and Finding of Significant Linkage to Chromosome 6q22

2004 • 173 citations

Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate

1999 • 173 citations

Alterations in plasma prolyl endopeptidase activity in depression, mania, and schizophrenia: effects of antidepressants, mood stabilizers, and antipsychotic drugs

1995 • 160 citations

Guidelines for Genotyping in Genomewide Linkage Studies: Single-Nucleotide–Polymorphism Maps Versus Microsatellite Maps

2004 • 155 citations

A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22–21, 4p16, 6q14–22, 10q26 and 16p13.3

2002 • 130 citations

Evidence for a putative bipolar disorder locus on 2p13–16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21–24, 13q32, 14q21 and 17q11–12

2003 • 124 citations

Mathematical limits of multilocus models: the genetic transmission of bipolar disorder.

1995 • 119 citations

Lower serum prolyl endopeptidase enzyme activity in major depression: Further evidence that peptidases play a role in the pathophysiology of depression

1994 • 117 citations

Efficiency of typing unaffected relatives in an affected-sib-pair linkage study with single-locus and multiple tightly linked markers.

1995 • 107 citations

Relationship estimation in affected sib pair analysis of late-onset diseases.

1997 • 106 citations

Eph Receptors, Ephrins, and Synaptic Function

2004 • 105 citations

Analysis of human genetic linkage, revised edition

1993 • 105 citations

Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees

2003 • 85 citations

Relationship Estimation in Affected Sib Pair Analysis of Late-Onset Diseases

1997 • 82 citations

The Wellcome trust UK–Irish bipolar affective disorder sibling-pair genome screen: first stage report

2002 • 72 citations

Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees

2004 • 68 citations

Can Eph Receptors Stimulate the Mind?

2002 • 62 citations

Efficient strategies for genome scanning using maximum-likelihood affected-sib-pair analysis.

1997 • 58 citations

Anticipation and repeat expansion in bipolar disorder

2003 • 57 citations

Genome‐wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: Fine mapping adds support on chromosomes 6 and 11

2004 • 44 citations

Anesthesia induced retrograde amnesia is ameliorated by ephrinA5-IgG in mice: EphA receptor tyrosine kinases are involved in mammalian memory

2000 • 44 citations

A genome screen of a large bipolar affective disorder pedigree supports evidence for a susceptibility locus on chromosome 13q

2001 • 43 citations

Detecting Gene-Gene Interactions Using Affected Sib Pair Analysis with Covariates

2002 • 41 citations

Covariates in linkage analysis

1999 • 39 citations

Fine mapping supports previous linkage evidence for a bipolar disorder susceptibility locus on 13q32

2001 • 35 citations

Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series

2003 • 31 citations

Hereditary Hearing Loss and its Syndromes, 2nd edn

2005 • 21 citations

MEGABASE/PKD: A Genetic Database for Polycystic Kidney Disease

2015 • 14 citations