Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12

A Diagnostic Interview

1978 • 5,735 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

MANIC DEPRESSIVE ILLNESS

1984 • 3,013 citations

Parametric and nonparametric linkage analysis: a unified multipoint approach.

1996 • 2,905 citations

Strategies for multilocus linkage analysis in humans.

1984 • 2,600 citations

Manic-depressive illness

1991 • 1,538 citations

Construction of multilocus genetic linkage maps in humans.

1987 • 1,461 citations

Best Estimate of Lifetime Psychiatric Diagnosis

1982 • 1,435 citations

A Family Study of Schizoaffective, Bipolar I, Bipolar II, Unipolar, and Normal Control Probands

1982 • 995 citations

Allele-Sharing Models: LOD Scores and Accurate Linkage Tests

1997 • 993 citations

Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family

2001 • 729 citations

Genetics of bipolar disorder

1999 • 529 citations

A Danish Twin Study of Manic-Depressive Disorders

1977 • 501 citations

A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2

1999 • 399 citations

Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene.

1994 • 378 citations

Genomewide Genetic Linkage Analysis Confirms the Presence of Susceptibility Loci for Schizophrenia, on Chromosomes 1q32.2, 5q33.2, and 8p21-22 and Provides Support for Linkage to Schizophrenia, on Chromosomes 11q23.3-24 and 20q12.1-11.23

2001 • 376 citations

Adoption study supporting genetic transmission in manic–depressive illness

1977 • 376 citations

A full genome scan for late onset Alzheimer's disease

1999 • 358 citations

Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect.

1995 • 347 citations

Chromosome 1 loci in Finnish schizophrenia families

2001 • 315 citations

A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22

2001 • 278 citations

Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23

1996 • 260 citations

Are Schizophrenic and Bipolar Disorders Related? A Review of Family and Molecular Studies

2019 • 245 citations

Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24

1999 • 221 citations

Initial genome scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 1, 6, 8, 10, and 12

1997 • 218 citations

Patterns of maternal transmission in bipolar affective disorder.

1995 • 216 citations

A manic depressive history

1996 • 211 citations

Genetic approaches to mental disorders

1994 • 196 citations

A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees

1996 • 175 citations

Genetic Approaches to Mental Disorders

1995 • 173 citations

A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish

1996 • 173 citations

Chromosome 18 DNA markers and manic-depressive illness : evidence for a susceptibility gene

1994 • 169 citations

Diagnostic Reliability of Bipolar II Disorder

2002 • 153 citations

A Two-Stage Genome Scan for Schizophrenia Susceptibility Genes in 196 Affected Sibling Pairs

1999 • 144 citations

A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q

2001 • 139 citations

Maternal inheritance and chromosome 18 allele sharing in unilineal bipolar illness pedigrees

1996 • 138 citations

Initial Genome Scan of the NIMH Genetics Initiative Bipolar Pedigrees: Chromosomes 4, 7, 9, 18, 19, 20, and 21q

1997 • 133 citations

Familial Cosegregation of Major Affective Disorder and Darier's Disease (Keratosis Follicularis)

1994 • 133 citations

Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families

1999 • 129 citations

Characterization of a Novel Src-like Adapter Protein That Associates with the Eck Receptor Tyrosine Kinase

1995 • 127 citations

Genomic survey of bipolar illness in the NIMH genetics initiative pedigrees: A preliminary report

1997 • 124 citations

Possible locus for bipolar disorder near the dopamine transporter on chromosome 5

1996 • 107 citations

Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: Chromosomes 2, 11, 13, 14, and X

1997 • 104 citations

Linkage of Bipolar Affective Disorder to Chromosome 18 Markers in a New Pedigree Series

1997 • 100 citations

Linkage of Bipolar Disorder to Chromosome 18q and the Validity of Bipolar II Disorder

2001 • 98 citations

A Susceptibility Locus for Bipolar Affective Disorder on Chromosome 4q35

1998 • 96 citations

Mapping of the Gene for the Mel1a-Melatonin Receptor to Human Chromosome 4 (MTNR1A) and Mouse Chromosome 8 (Mtnr1a)

1995 • 88 citations

Genetics of Psychiatric Disease

2000 • 86 citations

Genetic Association Analysis of Serotonin System Genes in Bipolar Affective Disorder

1999 • 83 citations

Second stage of a genome scan of schizophrenia: Study of five positive regions in an expanded sample

2000 • 80 citations

Linkage analysis of families with bipolar illness and chromosome 18 markers

1996 • 79 citations

Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma.

1996 • 76 citations

Full-Genome Scan for Linkage in 50 Families Segregating the Bipolar Affective Disease Phenotype

2000 • 76 citations

The Wellcome trust UK–Irish bipolar affective disorder sibling-pair genome screen: first stage report

2002 • 72 citations

5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait

2000 • 68 citations

Commentary:The role of meta-analysis in linkage studies of complex traits

1997 • 60 citations

Anticipation and repeat expansion in bipolar disorder

2003 • 57 citations

Parent-of-origin effect in transmission of bipolar disorder

1996 • 57 citations

Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands

2001 • 53 citations

Unipolar relatives in bipolar pedigrees

1993 • 51 citations

Type I bipolar disorder associated with a fragile site on chromosome 1

1995 • 46 citations

A European multicenter association study ofHTR2A receptor polymorphism in bipolar affective disorder

2000 • 46 citations

An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2–q11.2 in a large Turkish pedigree

2001 • 45 citations

Genetic variation of the 5-HT 2A receptor gene and bipolar affective disorder

1997 • 44 citations

A genome screen of a large bipolar affective disorder pedigree supports evidence for a susceptibility locus on chromosome 13q

2001 • 43 citations

Assessment of lineality in bipolar I linkage studies

1992 • 41 citations

No Evidence for Significant Linkage between Bipolar Affective Disorder and Chromosome 18 Pericentromeric Markers in a Large Series of Multiplex Extended Pedigrees

1998 • 38 citations

Evaluating the parent-of-origin effect in bipolar affective disorder

2000 • 36 citations

Point mutations within 663–666 bp of intron 6 of the human TDO2 gene, associated with a number of psychiatric disorders, damage the YY‐1 transcription factor binding site

1999 • 36 citations

Chromosome workshops 1998: Current state of psychiatric linkage

1999 • 36 citations

Search for a shared segment on chromosome 10q26 in patients with bipolar affective disorder or schizophrenia from the Faroe Islands

2002 • 36 citations

Report of the chromosome 18 workshop

1999 • 34 citations

Parental transmission and D18S37 allele sharing in bipolar affective disorder

1997 • 31 citations

The Human Glycine Receptor β Subunit Gene (GLRB): Structure, Refined Chromosomal Localization, and Population Polymorphism

1998 • 23 citations

Identifications, Classification, and Evolution of the Vertebrate α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid (AMPA) Receptor Subunit Genes

2001 • 23 citations

Linkage studies of bipolar disorder with chromosome 18 markers

1999 • 21 citations

The gene for the human Src‐like adaptor protein (hSLAP) is located within the 64‐kb intron of the thyroglobulin gene

1998 • 19 citations

Intrafamilial association of pericentric inversion of chromosome 9, inv (9)(p11-q21), and rapid cycling bipolar disorder

1998 • 16 citations

Search for bipolar disorder susceptibility loci: The application of a modified genome scan concentrating on gene-rich regions

2000 • 15 citations

Failure to demonstrate parent-of-origin effect in transmission of bipolar II disorder

1998 • 15 citations

The Protein Tyrosine Phosphatase ϵ Gene Maps to Mouse Chromosome 7 and Human Chromosome 10q26

1996 • 14 citations

Fine Mapping of the Human 5-HTR2a Gene to Chromosome 13q14 and Identification of Two Highly Polymorphic Linked Markers Suitable for Association Studies in Psychiatric Disorders

1997 • 13 citations

Linkage analysis with adequate modeling of a parent‐of‐origin effect

1999 • 12 citations

Localization of the cDNA for an α<sub>1</sub>-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13

1994 • 11 citations

Chromosomes 1, 2, and 7 workshop

1999 • 11 citations

No evidence to support an association between the oestrogen receptor beta gene and bipolar disorder

2001 • 9 citations

HP-UX ftp vulnerability

1995 • 6 citations

A trial to apply the concept of genomic imprinting to the manic-depressive illness.

1992 • 4 citations