Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder

Haploview: analysis and visualization of LD and haplotype maps

2004 • 14,114 citations

Molecular Physiology of P2X Receptors

2002 • 2,845 citations

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

2003 • 2,691 citations

Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.

1995 • 1,977 citations

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

2003 • 1,522 citations

Prospects for whole-genome linkage disequilibrium mapping of common disease genes

1999 • 1,453 citations

The prevalence and distribution of major depression in a national community sample: the National Comorbidity Survey

1994 • 1,417 citations

Pedigree disequilibrium tests for multilocus haplotypes

2003 • 1,153 citations

Evidence for an immune response in major depression: A review and hypothesis

1995 • 954 citations

Altered Cytokine Production in Mice Lacking P2X7Receptors

2001 • 918 citations

A Unified Approach to Adjusting Association Tests for Population Admixture with Arbitrary Pedigree Structure and Arbitrary Missing Marker Information

2000 • 629 citations

The Permeabilizing ATP Receptor, P2X7

1997 • 486 citations

Tissue distribution of the P2X7 receptor

1997 • 481 citations

Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression

2005 • 460 citations

IDO and interferon-α-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity

2004 • 431 citations

Production and Release of Neuroprotective Tumor Necrosis Factor by P2X₇Receptor-Activated Microglia

2004 • 389 citations

Proteomic and functional evidence for a P2X7 receptor signalling complex

2001 • 376 citations

Molecular physiology of p2x receptors and atp signalling at synapses

2001 • 368 citations

Extent and Distribution of Linkage Disequilibrium in Three Genomic Regions

2001 • 329 citations

Human genome sequence variation and the influence of gene history, mutation and recombination

2002 • 328 citations

A Glu-496 to Ala Polymorphism Leads to Loss of Function of the Human P2X7 Receptor

2001 • 311 citations

Power and Sample Size Calculations for Case-Control Genetic Association Tests when Errors Are Present: Application to Single Nucleotide Polymorphisms

2002 • 289 citations

Polymorphisms at the G72/G30 Gene Locus, on 13q33, Are Associated with Bipolar Disorder in Two Independent Pedigree Series*

2003 • 270 citations

Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28

2000 • 259 citations

Reanalysis of P2X₇Receptor Expression in Rodent Brain

2004 • 257 citations

Candidate genes, pathways and mechanisms for bipolar (manic–depressive) and related disorders: an expanded convergent functional genomics approach

2004 • 222 citations

Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24

1999 • 221 citations

The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs

2002 • 218 citations

Expression of P2X₇ purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X₇ receptors

2000 • 196 citations

Predisposition Locus for Major Depression at Chromosome 12q22-12q23.2

2003 • 196 citations

Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls

1994 • 190 citations

Cutting Edge: The Nucleotide Receptor P2X7 Contains Multiple Protein- and Lipid-Interaction Motifs Including a Potential Binding Site for Bacterial Lipopolysaccharide

2001 • 180 citations

Epithelial Membrane Proteins Induce Membrane Blebbing and Interact with the P2X7 Receptor C Terminus

2002 • 178 citations

Extracellular ATP and P2X7 receptors in neurodegeneration

2002 • 167 citations

An Ile-568 to Asn Polymorphism Prevents Normal Trafficking and Function of the Human P2X7 Receptor

2003 • 165 citations

ADP and AMP Induce Interleukin-1β Release from Microglial Cells through Activation of ATP-Primed P2X₇ Receptor Channels

2002 • 159 citations

The power of sample size and homogenous sampling: Association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder

2005 • 157 citations

A polygenic basis for late-onset disease

2003 • 155 citations

Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q

2003 • 152 citations

Familial Cosegregation of Major Affective Disorder and Darier's Disease (Keratosis Follicularis)

1994 • 133 citations

A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22–21, 4p16, 6q14–22, 10q26 and 16p13.3

2002 • 130 citations

High mutation detection rate inTCOF1 among Treacher Collins syndrome patients reveals clustering of mutations and 16 novel pathogenic changes

2000 • 128 citations

Nucleotide Diversity and Haplotype Structure of the Human Angiotensinogen Gene in Two Populations

2002 • 125 citations

ATP Induces a Rapid and Pronounced Increase in 2-Arachidonoylglycerol Production by Astrocytes, a Response Limited by Monoacylglycerol Lipase

2004 • 119 citations

Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23‐24.1

1995 • 107 citations

Lower-Than-Expected Linkage Disequilibrium between Tightly Linked Markers in Humans Suggests a Role for Gene Conversion

2001 • 107 citations

Association studies in psychiatric genetics

1997 • 105 citations

ERRORS AND LINKAGE DISEQUILIBRIUM INTERACT MULTIPLICATIVELY WHEN COMPUTING SAMPLE SIZES FOR GENETIC CASE-CONTROL ASSOCIATION STUDIES

2002 • 92 citations

An interactive web database of factor H-associated hemolytic uremic syndrome mutations: insights into the structural consequences of disease-associated mutations

2005 • 88 citations

Chronic Lithium Treatment Attenuates Intracellular Calcium Mobilization

2004 • 86 citations

Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder

2003 • 83 citations

A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12

2004 • 81 citations

Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder

2003 • 81 citations

Linkage at 12q24 with Systemic Lupus Erythematosus (SLE) Is Established and Confirmed in Hispanic and European American Families

2004 • 68 citations

Activation of P2X7 purinoceptor-stimulated TGF-β1 mRNA expression involves PKC/MAPK signalling pathway in a rat brain-derived type-2 astrocyte cell line, RBA-2

2003 • 68 citations

Localization of Bipolar Susceptibility Locus by Molecular Genetic Analysis of the Chromosome 12q23-q24 Region in Two Pedigrees With Bipolar Disorder and Darier’s Disease

2004 • 61 citations

Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands

2001 • 53 citations

The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products.

2005 • 39 citations

Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region

2005 • 36 citations

Linkage disequilibrium mapping of bipolar affective disorder at 12q23‐q24 provides evidence for association at CUX2 and FLJ32356

2004 • 26 citations

Identification of a potential Bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4

2005 • 26 citations