Human class IV alcohol dehydrogenase: kinetic mechanism, functional roles and medical relevance

High Blood Alcohol Levels in Women

1990 • 1,248 citations

Retinoids in Embryonal Development

2000 • 859 citations

3 Alcohol Dehydrogenases

1975 • 706 citations

Studies on Liver Alcohol Dehydrogenase. II. The Kinetics of the Compound of Horse Liver Alcohol Dehydrogenase and Reduced Diphosphopyridine Nucleotide.

1951 • 435 citations

Biological Macromolecules and Assemblies

1987 • 400 citations

Impaired Locomotion and Dopamine Signaling in Retinoid Receptor Mutant Mice

1998 • 357 citations

An Essential Role for Retinoid Receptors RARβ and RXRγ In Long-Term Potentiation and Depression

1998 • 316 citations

The metabolism of ethanol and its metabolic effects.

1972 • 291 citations

Alcohol, vitamin A, and β-carotene: adverse interactions, including hepatotoxicity and carcinogenicity

1999 • 262 citations

Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family

1999 • 255 citations

The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver

1972 • 250 citations

Product Inhibition Studies on Yeast and Liver Alcohol Dehydrogenases^*

1963 • 241 citations

Purification and characterization of a new alcohol dehydrogenase from human stomach.

1991 • 190 citations

Retinoic Acid Synthesis in Mouse Embryos during Gastrulation and Craniofacial Development Linked to Class IV Alcohol Dehydrogenase Gene Expression

1996 • 179 citations

State of Oxidation-Reduction and State of Binding in the Cytosolic NADH-System as Disclosed by Equilibration with Extracellular Lactate/Pyruvate in Hemoglobin-Free Perfused Rat Liver

1972 • 163 citations

Kinetic Studies of Liver Alcohol Dehydrogenase and pH Effects with Coenzyme Preparations of High Purity

1963 • 158 citations

Alcohol and the Gastrointestinal Tract

1980 • 151 citations

Alcohol dehydrogenase in human tissues: localisation of transcripts coding for five classes of the enzyme

1996 • 144 citations

Alcohol and Aldehyde Dehydrogenases in Human Esophagus: Comparison With the Stomach Enzyme Activities

1993 • 141 citations

Regulation of the mammalian alcohol dehydrogenase genes

2000 • 138 citations

Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver

1998 • 134 citations

Rate‐Limiting Factors in Ethanol Oxidation by Isolated Rat‐Liver Parenchymal Cells

1973 • 130 citations

Expression and activities of class IV alcohol dehydrogenase and class III aldehyde dehydrogenase in human mouth

1996 • 130 citations

Human stomach alcohol and aldehyde dehydrogenases: Comparison of expression pattern and activities in alimentary tract

1997 • 118 citations

Identification of Endogenous Retinoids, Enzymes, Binding Proteins, and Receptors during Early Postimplantation Development in Mouse: Important Role of Retinal Dehydrogenase Type 2 in Synthesis of All-trans-Retinoic Acid

2000 • 115 citations

Ethnic Differences in Gastric α‐Alcohol Dehydrogenase Activity and Ethanol First‐Pass Metabolism

1996 • 111 citations

Distinct Retinoid Metabolic Functions for Alcohol Dehydrogenase Genes Adh1 and Adh4 in Protection against Vitamin A Toxicity or Deficiency Revealed in Double Null Mutant Mice

2002 • 101 citations

Contribution to first‐pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family

1998 • 94 citations

Lack of alcohol dehydrogenase isoenzyme activities in the stomach of Japanese subjects

1991 • 94 citations

Expression Patterns of Class I and Class IV Alcohol Dehydrogenase Genes in Developing Epithelia Suggest a Role for Alcohol Dehydrogenase in Local Retinoic Acid Synthesis

1996 • 86 citations

Genetic dissection of retinoid dehydrogenases

2001 • 84 citations

Impaired retinol utilization inAdh4 alcohol dehydrogenase mutant mice

1999 • 78 citations

Alcohol and the Gastrointestinal Tract

1996 • 75 citations

X-ray Structure of Human Class IV ςς Alcohol Dehydrogenase

1997 • 75 citations

Initiation of retinoid signaling in primitive streak mouse embryos: Spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesis

1997 • 74 citations

Regional Restriction of Alcohol/Retinol Dehydrogenases along the Mouse Gastrointestinal Epithelium

1997 • 72 citations

Alcohol dehydrogenase from human stomach: variability in normal mucosa and effect of age, gender, ADH3 phenotype and gastric region.

1994 • 71 citations

Genetic Polymorphism and Activities of Human Colon Alcohol and Aldehyde Dehydrogenases: No Gender and Age Differences

1994 • 65 citations

Localization of Class I and Class IV Alcohol Dehydrogenases in Mouse Testis and Epididymis: Potential Retinol Dehydrogenases for Endogenous Retinoic Acid Synthesis1

1997 • 64 citations

Distribution of alcohol dehydrogenase mRNA in the rat central nervous system.

2001 • 63 citations

Alcohol in Health and Disease

2001 • 62 citations

Identification of a human stomach alcohol dehydrogenase with distinctive kinetic properties.

1990 • 58 citations

Pharmacogenetics of the Alcohol Dehydrogenase System

2000 • 57 citations

Alcohol dehydrogenase of human and rat blood vessels

1997 • 56 citations

Agonist: gastric first pass metabolism of alcohol.

1994 • 52 citations

Alcohol in Health and Disease

2001 • 49 citations

Class IV alcohol/retinol dehydrogenase localization in epidermal basal layer: Potential site of retinoic acid synthesis during skin development

1997 • 44 citations

cDNA Sequence and Catalytic Properties of a Chick Embryo Alcohol Dehydrogenase That Oxidizes Retinol and 3β,5α-Hydroxysteroids

1997 • 41 citations

Kinetic Mechanism of Human Class IV Alcohol Dehydrogenase Functioning as Retinol Dehydrogenase

2002 • 41 citations

Functional Polymorphism of Alcohol and Aldehyde Dehydrogenases

2001 • 40 citations

Alcohol Dehydrogenase

1980 • 39 citations

Molecular Basis for Differential Substrate Specificity in Class IV Alcohol Dehydrogenases

2000 • 36 citations

Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes

2002 • 35 citations

Antagonist: the case against first-pass metabolism of ethanol in the stomach.

1994 • 34 citations

ADH4‐lacZ Transgenic Mouse Reveals Alcohol Dehydrogenase Localization in Embryonic Midbrain/ Hindbrain, Otic Vesicles, and Mesencephalic, Trigeminal, Facial, and Olfactory Neural Crest

1998 • 32 citations

Human Alcohol Dehydrogenase Family

1999 • 31 citations

No Sex and Age Influence on the Expression Pattern and Activities of Human Gastric Alcohol and Aldehyde Dehydrogenases

2000 • 29 citations

Distribution of alcohol dehydrogenase mRNA in the rat central nervous system. . Consequences for brain ethanol and retinoid metabolism

2001 • 27 citations

Human alcohol dehydrogenase family. Functional classification, ethanol/retinol metabolism, and medical implications.

1999 • 26 citations

Regional Distribution of Mammalian Corneal Aldehyde Dehydrogenase and Alcohol Dehydrogenase

1992 • 25 citations

Molecular modelling of human gastric alcohol dehydrogenase (class IV) and substrate docking: differences towards the classical liver enzyme (class I)

1996 • 24 citations

Expression, Activities, and Kinetic Mechanism of Human Stomach Alcohol Dehydrogenase

1996 • 16 citations

Mouse alcohol dehydrogenase 4: kinetic mechanism, substrate specificity and simulation of effects of ethanol on retinoid metabolism

2001 • 16 citations

Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis

1999 • 14 citations

Regulation of Human Alcohol Dehydrogenase GeneADH7: Importance of an AP-1 Site

1998 • 11 citations