Pharmacogenetics of the Alcohol Dehydrogenase System

Short-chain dehydrogenases/reductases (SDR)

1995 • 1,228 citations

Three-dimensional structure of horse liver alcohol dehydrogenase at 2.4 Å resolution

1976 • 691 citations

Distribution of ADH2 and ALDH2 genotypes in different populations

1992 • 547 citations

Interaction between the Functional Polymorphisms of the Alcohol-Metabolism Genes in Protection against Alcoholism

1999 • 471 citations

Interactions of retinoid binding proteins and enzymes in retinoid metabolism

1999 • 410 citations

Developmental changes and polymorphism in human alcohol dehydrogenase

1971 • 375 citations

Evidence for the identity of glutathione‐dependent formaldehyde dehydrogenase and class III alcohol dehydrogenase

1989 • 339 citations

S-Nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III isoenzyme

1998 • 279 citations

Genetic polymorphism of alcohol dehydrogenase in europeans: TheADH2*2 allele decreases the risk for alcoholism and is associated withADH3*1

2000 • 261 citations

Linkage Disequilibrium at the ADH2 and ADH3 Loci and Risk of Alcoholism

1999 • 258 citations

Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family

1999 • 255 citations

INVOLVEMENT OF GENETIC POLYMORPHISM OF ALCOHOL AND ALDEHYDE DEHYDROGENASES IN INDIVIDUAL VARIATION OF ALCOHOL METABOLISM

1994 • 215 citations

SDR and MDR: completed genome sequences show these protein families to be large, of old origin, and of complex nature

1999 • 197 citations

Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome

1996 • 189 citations

Metabolic Deficiencies in Alcohol Dehydrogenase Adh1,Adh3, and Adh4 Null Mutant Mice

1999 • 178 citations

Genetics of Human Alcohol and Aldehyde Dehydrogenases

1986 • 177 citations

ADH Genotypes and Alcohol Use and Dependence in Europeans

1998 • 175 citations

Catalytic Efficiency of Human Alcohol Dehydrogenases for Retinol Oxidation and Retinal Reduction

1994 • 172 citations

A Super-Family of Medium-Chain Dehydrogenases/Reductases (MDR). Sub-Lines including zeta-Crystallin, Alcohol and Polyol Dehydrogenases, Quinone Oxidoreductases, Enoyl Reductases, VAT-1 and other Proteins

1994 • 154 citations

Association of the ADH2*2 allele with reduced ethanol consumption in Jewish men in Israel: a pilot study.

1998 • 148 citations

Alcohol dehydrogenase in human tissues: localisation of transcripts coding for five classes of the enzyme

1996 • 144 citations

Fundamental molecular differences between alcohol dehydrogenase classes.

1994 • 137 citations

The contribution of polymorphism in the alcohol dehydrogenase β subunit to alcohol sensitivity in a Japanese population

1996 • 128 citations

Physical and enzymatic properties of a class III isozyme of human liver alcohol dehydrogenase: .chi.-ADH

1984 • 122 citations

The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 å resolution 1 1Edited by R. Huber

1998 • 105 citations

Purification and structural characterization of placental NAD+-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family

1990 • 105 citations

Human liver alcohol dehydrogenase: amino acid substitution in the beta 2 beta 2 Oriental isozyme explains functional properties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme.

1984 • 99 citations

Contribution to first‐pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family

1998 • 94 citations

Structure of human χχ alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase

1997 • 92 citations

Eye lens .zeta.-crystallin relationships to the family of "long-chain" alcohol/polyol dehydrogenases. Protein trimming and conservation of stable parts

1989 • 91 citations

On the role of Glu‐68 in alcohol dehydrogenase

1995 • 89 citations

Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.

1991 • 85 citations

Genetic polymorphism of alcohol and aldehyde dehydrogenase and the effects on alcohol metabolism.

1993 • 79 citations

Retinoids, ω‐hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H₂‐receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase

1998 • 75 citations

X-ray Structure of Human Class IV ςς Alcohol Dehydrogenase

1997 • 75 citations

Human class I alcohol dehydrogenases catalyze the interconversion of alcohols and aldehydes in the metabolism of dopamine

1986 • 75 citations

Alcohol metabolizing enzymes: Studies of isozymes in human biopsies and cultured fibroblasts

1979 • 72 citations

Activities of human alcohol dehydrogenases in the metabolic pathways of ethanol and serotonin

1999 • 72 citations

Enzymatic and structural differences between usual and atypical human liver alcohol dehydrogenases.

1981 • 70 citations

3.beta.-Hydroxy-5.beta.-steroid dehydrogenase activity of human liver alcohol dehydrogenase is specific to .gamma.-subunits

1988 • 60 citations

Mycothiol‐Dependent Formaldehyde Dehydrogenase, A Prokaryotic Medium‐Chain Dehydrogenase/Reductase, Phylogenetically Links Different Eukaroytic Alcohol Dehydrogenases Primary Structure, Conformational Modelling and Functional Correlations

1997 • 51 citations

An ethanol‐inducible MDR ethanol dehydrogenase/acetaldehyde reductase in Escherichia coli

1999 • 48 citations

Human class I alcohol dehydrogenases catalyze the oxidation of glycols in the metabolism of norepinephrine.

1985 • 46 citations

Class III alcohol dehydrogenase from Saccharomyces cerevisiae: Structural and enzymatic features differ toward the human/mammalian forms in a manner consistent with functional needs in formaldehyde detoxication

1995 • 42 citations

Structural and Enzymatic Properties of a Gastric NADP(H)- dependent and Retinal-active Alcohol Dehydrogenase

1999 • 37 citations

Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene

1991 • 32 citations

Cloning and sequencing of a processed pseudogene derived from a human class III alcohol dehydrogenase gene.

1990 • 27 citations

Alcohol dehydrogenases inXenopus development: Conserved expression of ADH1 and ADH4 in epithelial retinoid target tissues

1998 • 18 citations

Formation of 20-oxoleukotriene B4 by an alcohol dehydrogenase isolated from human neutrophils

1990 • 14 citations

Isozyme Multiplicity with Anomalous Dimer Patterns in a Class III Alcohol Dehydrogenase. Effects on the Activity and Quaternary Structure of Residue Exchanges at “Nonfunctional” Sites in a Native Protein

1996 • 12 citations

Linking of Isozyme and Class Variability Patterns in the Emergence of Novel Alcohol Dehydrogenase Functions. Characterization of Isozymes in Uromastix Hardwickii

1996 • 11 citations