Identification of Endogenous Retinoids, Enzymes, Binding Proteins, and Receptors during Early Postimplantation Development in Mouse: Important Role of Retinal Dehydrogenase Type 2 in Synthesis of All-trans-Retinoic Acid

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

A decade of molecular biology of retinoic acid receptors

1996 • 2,893 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

The Atlas of Mouse Development

1992 • 1,782 citations

The atlas of mouse development

1993 • 1,427 citations

Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

1999 • 1,051 citations

Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

1998 • 984 citations

Retinoic acid causes an anteroposterior transformation in the developing central nervous system

1989 • 885 citations

Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.

1991 • 730 citations

Transport and Storage of Vitamin A

1990 • 618 citations

Vitamin A in Health and Disease

1994 • 602 citations

Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope

1993 • 577 citations

Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development

1997 • 527 citations

Retinoic acid receptors and cellular retinoid binding proteins : II. Their differential pattern of transcription during early morphogenesis in mouse embryos

1991 • 527 citations

The retinoid signaling pathway: molecular and genetic analyses

1994 • 508 citations

Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development

1997 • 428 citations

Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

1990 • 351 citations

Molecular Identification of a Major Retinoic‐Acid‐Synthesizing Enzyme, a Retinaldehyde‐Specific Dehydrogenase

1996 • 342 citations

Cellular retinol-binding protein I is essential for vitamin A homeostasis

1999 • 314 citations

Cellular Retinoid-Binding Proteins

1987 • 312 citations

Developmental expression of murine retinoid X receptor (RXR) genes

1994 • 297 citations

Polarizing activity and retinoid synthesis in the floor plate of the neural tube

1990 • 292 citations

The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification

1993 • 285 citations

Involvement of Alcohol Dehydrogenase, Short-Chain Dehydrogenase/Reductase, Aldehyde Dehydrogenase, and Cytochrome P450 in the Control of Retinoid Signaling by Activation of Retinoic Acid Synthesis

1996 • 271 citations

Developmental analysis of the retinoic acid-inducible RAR-βJ2 promoter in transgenic animals

1991 • 258 citations

Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud

1990 • 252 citations

Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay

1992 • 250 citations

The Retinal Pigment Epithelial-specific 11-cis Retinol Dehydrogenase Belongs to the Family of Short Chain Alcohol Dehydrogenases

1995 • 250 citations

Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo

1995 • 229 citations

Evidence that Hensen's node is a site of retinoic acid synthesis

1992 • 216 citations

Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein.

1990 • 212 citations

Biochemical Pathways of Retinoid Transport, Metabolism, and Signal Transduction

1996 • 207 citations

Physiological Substrates for Rat Alcohol Dehydrogenase Classes: Aldehydes of Lipid Peroxidation, ω-Hydroxyfatty Acids, and Retinoids

1993 • 207 citations

Retinoic acid modifies the pattern of cell differentiation in the central nervous system of neurula stage Xenopus embryos

1991 • 204 citations

The distribution of endogenous retinoic acid in the chick embryo: implications for developmental mechanisms

1998 • 204 citations

Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis

1992 • 201 citations

Retinoic Acid Synthesis in Mouse Embryos during Gastrulation and Craniofacial Development Linked to Class IV Alcohol Dehydrogenase Gene Expression

1996 • 179 citations

Retinoid X receptors are essential for early mouse development and placentogenesis

1999 • 176 citations

Vitamin A deficiency and mutations of RXRα, RXRβ and RARα lead to early differentiation of embryonic ventricular cardiomyocytes

1997 • 171 citations

A novel retinol-binding protein from rat. Purification and partial characterization.

1984 • 170 citations

Transgenic indicator mice for studying activated retinoic acid receptors during development.

1992 • 170 citations

Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon.

1994 • 162 citations

Identification of mouse liver aldehyde dehydrogenases that catalyze the oxidation of retinaldehyde to retinoic acid

1991 • 152 citations

Cloning of a cDNA for Liver Microsomal Retinol Dehydrogenase

1995 • 125 citations

Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis.

1996 • 119 citations

Novel retinoic acid receptor ligands in Xenopus embryos.

1996 • 111 citations

Identification and Characterization of a Stereospecific Human Enzyme That Catalyzes 9-cis-Retinol Oxidation

1997 • 107 citations

Endogenous retinoids in the zebrafish embryo and adult

1996 • 107 citations

Cloning of a cDNA for a Second Retinol Dehydrogenase Type II

1995 • 99 citations

Contribution to first‐pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family

1998 • 94 citations

The identification of a 9- cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9- cis retinoic acid

1998 • 94 citations

cDNA Cloning and Characterization of a cis-Retinol/3α-Hydroxysterol Short-chain Dehydrogenase

1997 • 88 citations

Comparison of the tissue-specific expression and developmental regulation of two closely linked rodent genes encoding cytosolic retinol-binding proteins.

1987 • 86 citations

Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue

1999 • 81 citations

Impaired retinol utilization inAdh4 alcohol dehydrogenase mutant mice

1999 • 78 citations

Retinoids, ω‐hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H₂‐receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase

1998 • 75 citations

Initiation of retinoid signaling in primitive streak mouse embryos: Spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesis

1997 • 74 citations

cDNA Cloning, Tissue Distribution, and Substrate Characteristics of a cis-Retinol/3α-Hydroxysterol Short-chain Dehydrogenase Isozyme

1998 • 67 citations

Cloning of a rat cDNA encoding retinol dehydrogenase isozyme type III

1996 • 66 citations

Quantitative determination of endogenous retinoids in mouse embryos by high-performance liquid chromatography with on-line solid-phase extraction, column switching and electrochemical detection

1998 • 52 citations

The Intracellular Vitamin A-Binding Proteins: An Overview of Their Functions*

2009 • 46 citations

Expression of retinoic acid receptor and retinoid X receptor subtypes in rat liver cells: Implications for retinoid signalling in parenchymal, endothelial, Kupffer and stellate cells

1998 • 44 citations

Stimulation of premature retinoic acid synthesis in Xenopus embryos following premature expression of aldehyde dehydrogenase ALDH1

1999 • 44 citations

The visual cycle retinol dehydrogenase: possible involvement in the 9‐cis retinoic acid biosynthetic pathway

1998 • 42 citations

Embryonic stem cells stably transfected with mRAR beta 2-lacZ exhibit specific expression in chimeric embryos.

1992 • 31 citations

Changes of egg retinoids during the development of Xenopus laevis

1990 • 20 citations