Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis

An all atom force field for simulations of proteins and nucleic acids

1986 • 3,388 citations

Solvent-Accessible Surfaces of Proteins and Nucleic Acids

1983 • 2,685 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

Structure-Based Strategies for Drug Design and Discovery

1992 • 972 citations

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

1993 • 738 citations

Three-dimensional structure of horse liver alcohol dehydrogenase at 2.4 Å resolution

1976 • 691 citations

Human aldehyde dehydrogenase gene family

1998 • 473 citations

Biochemistry and Pharmacology of Ethanol

1979 • 353 citations

Structure-Based Molecular Design

1994 • 323 citations

Polarizing activity and retinoid synthesis in the floor plate of the neural tube

1990 • 292 citations

The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification

1993 • 285 citations

Involvement of Alcohol Dehydrogenase, Short-Chain Dehydrogenase/Reductase, Aldehyde Dehydrogenase, and Cytochrome P450 in the Control of Retinoid Signaling by Activation of Retinoic Acid Synthesis

1996 • 271 citations

Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud

1990 • 252 citations

The Retinal Pigment Epithelial-specific 11-cis Retinol Dehydrogenase Belongs to the Family of Short Chain Alcohol Dehydrogenases

1995 • 250 citations

Physiological Substrates for Rat Alcohol Dehydrogenase Classes: Aldehydes of Lipid Peroxidation, ω-Hydroxyfatty Acids, and Retinoids

1993 • 207 citations

Retinoic Acid Synthesis in Mouse Embryos during Gastrulation and Craniofacial Development Linked to Class IV Alcohol Dehydrogenase Gene Expression

1996 • 179 citations

Structures of Horse Liver Alcohol Dehydrogenase Complexed with NAD+ and Substituted Benzyl Alcohols

1994 • 177 citations

Catalytic Efficiency of Human Alcohol Dehydrogenases for Retinol Oxidation and Retinal Reduction

1994 • 172 citations

Vitamin A in Human Skin: II Concentrations of Carotene, Retinol and Dehydroretinol in Various Components of Normal Skin

1982 • 145 citations

The equilibrium between vitamin A alcohol and aldehyde in the presence of alcohol dehydrogenase

1951 • 142 citations

Molecular dynamics simulations of alcohol dehydrogenase with a four‐ or five‐coordinate catalytic zinc ion

1995 • 127 citations

Cloning of a cDNA for Liver Microsomal Retinol Dehydrogenase

1995 • 125 citations

Binding specificities of cellular retinol-binding protein and cellular retinol-binding protein, type II.

1987 • 122 citations

Purification and molecular properties of mouse alcohol dehydrogenase isozymes

1983 • 121 citations

4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors.

1996 • 115 citations

Novel retinoic acid receptor ligands in Xenopus embryos.

1996 • 111 citations

Identification and Characterization of a Stereospecific Human Enzyme That Catalyzes 9-cis-Retinol Oxidation

1997 • 107 citations

A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid

1995 • 103 citations

Crystal Structures of Holo and Apo-cellular Retinol-binding Protein II

1993 • 96 citations

Contribution to first‐pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family

1998 • 94 citations

The identification of a 9- cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9- cis retinoic acid

1998 • 94 citations

Structure of human χχ alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase

1997 • 92 citations

cDNA Cloning and Characterization of a cis-Retinol/3α-Hydroxysterol Short-chain Dehydrogenase

1997 • 88 citations

A Comparison of Retinene Reductase and Alcohol Dehydrogenase of Rat Liver

1961 • 87 citations

Expression Patterns of Class I and Class IV Alcohol Dehydrogenase Genes in Developing Epithelia Suggest a Role for Alcohol Dehydrogenase in Local Retinoic Acid Synthesis

1996 • 86 citations

Expression and Kinetic Characterization of Recombinant Human Stomach Alcohol Dehydrogenase

1995 • 86 citations

Structures of Three Human β Alcohol Dehydrogenase Variants

1994 • 85 citations

Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.

1991 • 85 citations

Retinoids, ω‐hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H₂‐receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase

1998 • 75 citations

X-ray Structure of Human Class IV ςς Alcohol Dehydrogenase

1997 • 75 citations

Initiation of retinoid signaling in primitive streak mouse embryos: Spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesis

1997 • 74 citations

Regional Restriction of Alcohol/Retinol Dehydrogenases along the Mouse Gastrointestinal Epithelium

1997 • 72 citations

The Alcohol Dehydrogenase System

1995 • 68 citations

Localization of Class I and Class IV Alcohol Dehydrogenases in Mouse Testis and Epididymis: Potential Retinol Dehydrogenases for Endogenous Retinoic Acid Synthesis1

1997 • 64 citations

Human breast cancer cells and normal mammary epithelial cells: retinol metabolism and growth inhibition by the retinol metabolite 4-oxoretinol.

1997 • 60 citations

Endogenous Retinoids in the Early Avian Embryo

1995 • 60 citations

Effect of Cellular Retinol-Binding Protein on Retinol Oxidation by Human Class IV Retinol/Alcohol Dehydrogenase and Inhibition by Ethanol

1998 • 55 citations

Crystal structure of cod liver class I alcohol dehydrogenase: Substrate pocket and structurally variable segments

1996 • 51 citations

Temporal distribution, localization and metabolism of all-trans-retinol, didehydroretinol and all-trans-retinal during Xenopus development

1994 • 49 citations

Nonethanol Substrates of Alcohol Dehydrogenase

1979 • 45 citations

Class IV alcohol/retinol dehydrogenase localization in epidermal basal layer: Potential site of retinoic acid synthesis during skin development

1997 • 44 citations

cDNA Sequence and Catalytic Properties of a Chick Embryo Alcohol Dehydrogenase That Oxidizes Retinol and 3β,5α-Hydroxysteroids

1997 • 41 citations

Retinoic Acid and Alcohol/Retinol Dehydrogenase in the Mouse Adrenal Gland: A Potential Endocrine Source of Retinoic Acid during Development*

1997 • 33 citations

Placental transfer and developmental effects of 9‐cis retinoic acid in mice

1995 • 28 citations

Molecular modelling of human gastric alcohol dehydrogenase (class IV) and substrate docking: differences towards the classical liver enzyme (class I)

1996 • 24 citations

All ‐trans 3,4‐didehydroretinoic acid equals all‐trans retinoic acid in support of chick neuronal development

1996 • 19 citations

Xenopus laevis: a model system for the study of embryonic retinoid metabolism. II. Embryonic metabolism of all-trans-3,4-didehydroretinol to all-trans-3,4-didehydroretinoic acid.

1995 • 18 citations

ADH1 and ADH4 alcohol/retinol dehydrogenases in the developing adrenal blastema provide evidence for embryonic retinoid endocrine function

1998 • 16 citations

Computational Modeling of a Putative Fetal Alcohol Syndrome Mechanism

1995 • 11 citations

Retinoic Acid and Alcohol/Retinol Dehydrogenase in the Mouse Adrenal Gland: A Potential Endocrine Source of Retinoic Acid during Development

1997 • 10 citations