Aging mechanisms in fruit flies

The Genome of Drosophila Melanogaster

1992 • 3,126 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

Longevity, senescence and the genome

1995 • 1,390 citations

Evolutionary biology of aging

1991 • 1,333 citations

Evolution in Age-Structured Populations

1994 • 1,308 citations

LABORATORY EVOLUTION OF POSTPONED SENESCENCE INDROSOPHILA MELANOGASTER

1984 • 774 citations

P-element-mediated enhancer detection: a versatile method to study development in Drosophila.

1989 • 679 citations

Optimally, mutation and the evolution of ageing

1993 • 652 citations

Laboratory Evolution of Postponed Senescence in Drosophila melanogaster

1984 • 641 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

Slowing of Mortality Rates at Older Ages in Large Medfly Cohorts

1992 • 612 citations

Genes that regulate both development and longevity in Caenorhabditis elegans.

1995 • 579 citations

SELECTION FOR DELAYED SENESCENCE IN DROSOPHILA MELANOGASTER

1984 • 562 citations

Demography of Genotypes: Failure of the Limited Life-Span Paradigm in Drosophila melanogaster

1992 • 425 citations

Longevity, senescence, and the genome

1992 • 409 citations

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.

1989 • 381 citations

DIRECT AND CORRELATED RESPONSES TO SELECTION ON AGE AT REPRODUCTION INDROSOPHILA MELANOGASTER

1992 • 311 citations

Selection on stress resistance increases longevity in Drosophila melanogaster

1992 • 304 citations

Expression of Heat Shock Protein 70 is Altered by Age and Diet at the Level of Transcription

1993 • 284 citations

Simultaneous Overexpression of Copper- and Zinc-containing Superoxide Dismutase and Catalase Retards Age-related Oxidative Damage and Increases Metabolic Potential in Drosophila melanogaster

1995 • 239 citations

Expression of heat shock protein 70 is altered by age and diet at the level of transcription.

1993 • 237 citations

Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats.

1990 • 222 citations

Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence.

1996 • 219 citations

Desiccation, Flight, Glycogen, and Postponed Senescence in Drosophila melanogaster

1992 • 192 citations

Physiological Mechanisms of Increased Stress Resistance in Drosophila melanogaster Selected for Postponed Senescence

1987 • 188 citations

Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress.

1995 • 171 citations

A genetic analysis of senescence in Drosophila

1994 • 166 citations

The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster

1992 • 163 citations

Molecular Biology of Aging: Gene Stability and Gene Expression

1986 • 163 citations

Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-span.

1990 • 162 citations

Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.

1989 • 159 citations

Effects of Cu-Zn Superoxide Dismutase Overexpression on Life Span and Resistance to Oxidative Stress in Transgenic Drosophila melanogaster

1993 • 156 citations

Urate-null rosy mutants of Drosophila melanogaster are hypersensitive to oxygen stress.

1992 • 143 citations

Elevated paraquat resistance can be used as a bioassay for longevity in a genetically based long‐lived strain of Drosophila

1991 • 142 citations

A Coordinate Upregulation of Antioxidant Gene Activities Is Associated With the Delayed Onset of Senescence in a Long-Lived Strain of Drosophila

1995 • 140 citations

Direct and Correlated Responses to Selection on Age at Reproduction in Drosophila melanogaster

1992 • 130 citations

Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced.

1993 • 121 citations

Expression of Bovine Superoxide Dismutase in Drosophila melanogaster Augments Resistance to Oxidative Stress

1991 • 117 citations

The genetics of catalase in Drosophila melanogaster: isolation and characterization of acatalasemic mutants.

1989 • 116 citations

THE EVOLUTION OF DEVELOPMENT INDROSOPHILA MELANOGASTERSELECTED FOR POSTPONED SENESCENCE

1994 • 115 citations

THE EVOLUTIONARY GENETICS OF MALE LIFE-HISTORY CHARACTERS INDROSOPHILA MELANOGASTER

1995 • 112 citations

Successful selection for increased longevity in Drosophila: Analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity

1987 • 104 citations

Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster.

1993 • 98 citations

Expression of bovine superoxide dismutase in Drosophila melanogaster augments resistance of oxidative stress.

1991 • 91 citations

Comparative biochemical and stress analysis of genetically selected drosophila strains with different longevities

1995 • 88 citations

EVOLUTIONARY EFFECTS OF SELECTION ON AGE AT REPRODUCTION IN LARVAL AND ADULT: DROSOPHILA MELANOGASTER

1993 • 81 citations

The genetics and cytology ofDrosophila Subobscura

1955 • 81 citations

Phenotypic consequences of copper-zinc superoxide dismutase overexpression in Drosophila melanogaster

1990 • 73 citations

Aging results in an unusual expression of Drosophila heat shock proteins.

1988 • 62 citations

Temporal patterns of gene expression in the antenna of the adult Drosophila melanogaster.

1995 • 61 citations

The effect of superoxide dismutase alleles on aging inDrosophila

1993 • 60 citations

The probability of survival of a mutant gene in an age-structured population and implications for the evolution of life-histories

1975 • 59 citations

Review of Genetic Investigations into the Aging Processes of Drosophila

1989 • 58 citations

Aging affects expression of 70-kDa heat shock proteins in Drosophila

1991 • 56 citations

The Evolution of Development in Drosophila melanogaster Selected for Postponed Senescence

1994 • 54 citations

Protein synthesis elongation factor EF-1 alpha expression and longevity in Drosophila melanogaster.

1994 • 50 citations

Regulation of gene expression is linked to life span in adult Drosophila.

1995 • 49 citations

Larval regulation of adult longevity in a genetically-selected long-lived strain of Drosophila

1993 • 49 citations

How Long Is the Human Life-Span?

1991 • 48 citations

The effects of enhanced expression of elongation factor EF-1? on lifespan inDrosophila melanogaster

1993 • 41 citations

Chromosomal localization and regulation of the longevity determinant genes in a selected strain of Drosophila melanogaster

1993 • 40 citations

The effects of enhanced expression of elongation factor EF-1α on lifespan in Drosophila melanogaster

1994 • 39 citations

Factors contributing to the plasticity of the extended longevity phenotypes of Drosophila

1996 • 39 citations

Transposable Elements as a Factor in the Aging of Drosophila melanogaster

1992 • 32 citations

Genetic and environmental factors regulating the expression of an extended longevity phenotype in a long lived strain ofDrosophila

1993 • 28 citations

A manganese superoxide dismutase-encoding cDNA from Drosophila melanogaster

1994 • 26 citations

Age Dependent Changes in Mitochondria

1985 • 23 citations

Interaction between nitric oxide and subsets of human T lymphocytes with differences in glutathione metabolism

2002 • 19 citations

P DNA element movement in somatic cells reduces lifespan in Drosophila melanogaster: evidence in support of the somatic mutation theory of aging

1995 • 19 citations

Heat shock induces changes in the expression and binding of ubiquitin in senescent Drosophila melanogaster

1993 • 17 citations

Aging in Drosophila

1994 • 17 citations

Changes in protein turnover after heat shock are related to accumulation of abnormal proteins in aging Drosophila melanogaster

1990 • 16 citations

Cancer genetics

1994 • 12 citations