Changes in protein turnover after heat shock are related to accumulation of abnormal proteins in aging Drosophila melanogaster

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

THE MAINTENANCE OF THE ACCURACY OF PROTEIN SYNTHESIS AND ITS RELEVANCE TO AGEING

1963 • 950 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

Mechanisms of Intracellular Protein Breakdown

1982 • 647 citations

The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts

1978 • 547 citations

Heat shock proteins: the search for functions.

1986 • 395 citations

Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides

1980 • 395 citations

Ubiquitin is a heat shock protein in chicken embryo fibroblasts.

1985 • 392 citations

Degradation of Abnormal Proteins in Escherichia coli

1972 • 298 citations

Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells

1976 • 234 citations

PROTEIN SYNTHESIS AND DEGRADATION DURING AGING AND SENESCENCE

1983 • 180 citations

Use of peptide tagging to detect proteins expressed from cloned genes: deletion mapping functional domains of Drosophila hsp 70.

1984 • 175 citations

Molecular genetics: What turns on heat shock genes?

1985 • 171 citations

c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock.

1988 • 154 citations

Microinjection of ubiquitin: changes in protein degradation in HeLa cells subjected to heat-shock.

1987 • 145 citations

Transfer RNA and Cell Differentiation

1970 • 140 citations

Biological aspects of aging

1962 • 127 citations

Codon-restriction theory of aging and development

1971 • 124 citations

Actin gene mutations in Drosophila ; heat shock activation in the indirect flight muscles

1985 • 116 citations

Protein degradation in human fibroblasts (WI-38). Effects of aging, viral transformation, and amino acid analogs.

1976 • 113 citations

Response of Intracellular Proteolysis to Alteration of Bacterial Protein and the Implications in Metabolic Regulation

1967 • 112 citations

Decreased protein and puromycinyl-peptide degradation in livers of senescent mice

1982 • 104 citations

Ubiquitin in stressed chicken embryo fibroblasts.

1988 • 96 citations

The formation of altered enzymes in aging animals

1979 • 93 citations

A model for ageing

1975 • 86 citations

Protein turnover in adult Drosophila

1970 • 68 citations

Stability of the Cellular Translation Process

1984 • 67 citations

The effect of age on the protein degradation system in the nematode Turbatrix aceti

1979 • 63 citations

Structural and Functional Changes in Nucleoprotein During the Ageing of the Cell

1970 • 62 citations

Aging results in an unusual expression of Drosophila heat shock proteins.

1988 • 62 citations

DNA synthesis in the absence of somatic cell division associated with ageing in Drosophila subobscura

1972 • 61 citations

Decrease in the rate of RNA and protein synthesis and degradation in the myocardium under long-term compensatory hyperfunction and on aging

1978 • 53 citations

Protein alterations in aging WI38 cells as determined by proteolytic susceptibility

1975 • 51 citations

Age-related changes in protein synthesis

1983 • 44 citations

Decreased protein synthesis by microsomes from aging Drosophila melanogester

1979 • 39 citations

Breakdown of aberrant protein in rabbit reticulocytes decreases with cell age

1980 • 37 citations

[A THEORY OF AGING].

1964 • 34 citations

A Model for Aging Based on Differential Repair of Somatic Mutational Damage

1974 • 29 citations

A Theory of Ageing

1959 • 24 citations

The degradation of normal and analogue-containing proteins in MRC-5 fibroblasts

1978 • 24 citations

Effects of Age and Cardiac Work in Vitro on Mitochondrial Oxidative Phosphorylation and (3H)-Leucine Incorporation

1981 • 18 citations

AMINO ACID PATTERN AND RATE OF PROTEIN SYNTHESIS IN AGING DROSOPHILA**This study was supported by grants from the Swiss National Science Foundation and the Georgesund Antoine Claraz-Schenkung.

1972 • 17 citations

Induction of heat shock proteins in young and senescent human diploid fibroblasts

1986 • 14 citations

LYSOSOMAL MECHANISMS OF PROTEIN DEGRADATION

1978 • 9 citations

A model of senescence as the piecewise loss of control over transcription

1981 • 6 citations

Controlling role of mitochondria in hypertrophying rat heart. V. Aschenbrenner

1977 • 3 citations

Age-related changes in turnover and concentration of a subset of thorax polypeptides from Drosophila melanogaster

1985 • 3 citations