Inhibition of iodoacetamide and t-butylhydroperoxide toxicity in LLC-PK1 cells by antioxidants: A role for lipid peroxidation in alkylation induced cytotoxicity

Methods in Enzymology , Vol

1966 • 26,261 citations

Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent

1968 • 7,671 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

Role of Ca2+ in toxic cell killing

1989 • 856 citations

Bioactivation of foreign compounds

1985 • 733 citations

The origin and characteristics of a pig kidney cell strain, LLC-PK1

1976 • 604 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes

1987 • 533 citations

Calcium-activated DNA Fragmentation in Rat Liver Nuclei

1989 • 281 citations

Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes

1985 • 265 citations

Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system.

1986 • 249 citations

tert-Butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids

1989 • 222 citations

Endogenous defenses against the cytotoxicity of hydrogen peroxide in cultured rat hepatocytes.

1985 • 196 citations

Biosynthesis and biotransformation of glutathioneS-Conjugates to toxic metabolites

1988 • 193 citations

Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress

1988 • 174 citations

Menadione-induced bleb formation in hepatocytes is associated with the oxidation of thiol groups in actin

1988 • 168 citations

Activation of microsomal glutathione S-transferase activity by sulfhydryl reagents

1979 • 168 citations

Evidence for carbon tetrachloride- and ethanol-induced lipid peroxidation in Vivo demonstrated by ethane production in mice and rats

1977 • 160 citations

A purified cysteine conjugate beta-lyase from rat kidney cytosol. Requirement for an alpha-keto acid or an amino acid oxidase for activity and identity with soluble glutamine transaminase K.

1986 • 153 citations

Mechanisms of cell injury in the killing of cultured hepatocytes by bromobenzene.

1982 • 135 citations

Mercuric reductase: homology to glutathione reductase and lipoamide dehydrogenase. Iodoacetamide alkylation and sequence of the active site peptide

1983 • 133 citations

Role of redox cycling and lipid peroxidation in bipyridyl herbicide cytotoxicity

1986 • 133 citations

Toxic consequence of the abrupt depletion of glutathione in cultured rat hepatocytes

1988 • 99 citations

The mechanism of cysteine conjugate cytotoxicity in renal epithelial cells. Covalent binding leads to thiol depletion and lipid peroxidation.

1990 • 97 citations

Further Studies on Lipid‐Peroxide Formation in Isolated Hepatocytes

1975 • 95 citations

Lipid peroxidation and paraquat toxicity

1979 • 90 citations

Paraquat toxicity is enhanced by iron and reduced by desferrioxamine in laboratory mice

1985 • 85 citations

Mitochondrial glutathione status during Ca2+ ionophore-induced injury to isolated hepatocytes

1988 • 83 citations

Lipid peroxidation, protein thiols and calcium homeostasis in bromobenzene-induced liver damage

1987 • 69 citations

Chemical modification of Cys‐374 of actin interferes with the formation of the profilactin complex

1984 • 66 citations

Interaction of tubulin with drugs and alkylating agents. 1. Alkylation of tubulin by iodo[14C]acetamide and N,N'-ethylenebis(iodoacetamide)

1981 • 64 citations

Lipid peroxidation: A possible mechanism of trichloroethylene-induced nephrotoxicity

1989 • 58 citations

Translational repression by chemical inducers of the stress response occurs by different pathways

1987 • 50 citations

tert–butylhydroperoxide—Induced toxicity in isolated hepatocytes: Contribution of thiol oxidation and lipid peroxidation

1986 • 48 citations

Oxidative cell injury in the killing of cultured hepatocytes by allyl alcohol

1988 • 43 citations

Cytotoxicity of the redox cycling compound diquat in isolated hepatocytes: Involvement of hydrogen peroxide and transition metals

1987 • 41 citations

Inhibition of lipid peroxidation by disulfiram and diethyldithiocarbamate does not prevent hepatotoxin-induced cell death in isolated rat hepatocytes. A study with allyl alcohol, tert-butyl hydroperoxide, diethyl maleate, bromoisovalerylurea and carbon tetrachloride

1988 • 40 citations

Peroxidation-dependent and peroxidation-independent mechanisms by which acetaminophen kills cultured rat hepatocytes

1988 • 37 citations

Effects of carbon tetrachloride on calcium homeostasis

1989 • 34 citations

Peroxidative Damage and Nephrotoxicity of Dichlorovinylcysteine in Mice

1989 • 32 citations

Interactions of the tau-tubulin-vinblastine complex with colchicine, podophyllotoxin, and N,N'-ethylenebis(iodoacetamide).

1982 • 31 citations

Toxicity of methylating agents in isolated hepatocytes

1988 • 31 citations

Relative contributions of protein sulfhydryl loss and lipid peroxidation to allyl alcohol-induced cytotoxicity in isolated rat hepatocytes

1989 • 30 citations

Percutaneous penetration of the magnesium sulfate adduct of dipyrithione in man

1977 • 22 citations

Studies on the catalytic site of rat liver HMG-CoA reductase: interaction with CoA-thioesters and inactivation by iodoacetamide.

1989 • 20 citations

Interaction of amide inhibitors with the active site of carbonic anhydrase: metal-induced deprotonation of the bound amide group is indicated by slow binding kinetics, by visible spectra of complexes with cobalt enzyme, and by pH effects on binding affinity

1987 • 20 citations

Chemical Modification and Fluorescence Labeling Study of Ca2+,Mg2+-Adenosine Triphosphatase of Sarcoplasmic Reticulum Using lodoacetamide and Its N-Substituted Derivatives1

1986 • 17 citations

Differential sensitivity of brain iodothyronine 5'-deiodinases to sulfhydryl-blocking reagents

1983 • 10 citations

A thiol-sensitive degradative process of liver uncouples autophosphorylation of the insulin receptor from insulin binding

1986 • 10 citations

NADPH-dependent generation of a cytosolic dithiol which activates hepatic iodothyronine 5′-deiodinase. Demonstration by alkylation with iodoacetamide

1986 • 9 citations

Effects of diamide and iodoacetamide on the expression of the glycoprotein IIb/IIIa complex on blood platelets

1985 • 6 citations

Report from Columbia University

1899 • 4 citations

Inhibition of the condensing component of chicken liver fatty acid synthase by iodoacetamide and 5,5′-dithiobis-(2-nitrobenzoic acid)

1983 • 2 citations