Interaction of amide inhibitors with the active site of carbonic anhydrase: metal-induced deprotonation of the bound amide group is indicated by slow binding kinetics, by visible spectra of complexes with cobalt enzyme, and by pH effects on binding affinity

Carbonic anhydrase: chemistry, physiology, and inhibition

1967 • 1,882 citations

The Carbon Dioxide Hydration Activity of Carbonic Anhydrase

1971 • 1,794 citations

Proton Transfer, Acid‐Base Catalysis, and Enzymatic Hydrolysis. Part I: ELEMENTARY PROCESSES

1964 • 1,743 citations

Coordinating properties of the amide bond. Stability and structure of metal ion complexes of peptides and related ligands

1982 • 1,548 citations

Interactions of histidine and other imidazole derivatives with transition metal ions in chemical and biological systems

1974 • 1,099 citations

Esterase Activities of Human Carbonic Anhydrases B and C

1967 • 939 citations

The Catalytic Mechanism of Carbonic Anhydrase

1973 • 293 citations

Carbon-13 nuclear magnetic resonance probe of active-site ionizations in human carbonic anhydrase B

1977 • 282 citations

Biophysics and Physiology of Carbon Dioxide

1980 • 151 citations

Carbonic Anhydrase: Structure, Catalytic Versatility, and Inhibition

1979 • 142 citations

Characterization of cobalt(II) bovine carbonic anhydrase and of its derivatives

1978 • 137 citations

A rapid and convenient preparation of apocarbonic anhydrase

1977 • 131 citations

Cobalt(II) as a probe of the structure and function of carbonic anhydrase

1983 • 131 citations

The catalytic versatility of erythrocyte carbonic anhydrase. VI. Kinetic studies of noncompetitive inhibition of enzyme-catalyzed hydrolysis of p-nitrophenyl acetate

1968 • 101 citations

Inhibition of Human Erythrocyte Carbonic Anhydrase B by Chloroacetyl Sulfonamides with Labeling of the Active Site

1967 • 87 citations

Influence of pH on the kinetics of complex formation between aromatic sulfonamides and human carbonic anhydrase

1970 • 84 citations

Nitrogen-15 nuclear magnetic resonance study of benzenesulfonamide and cyanate binding to carbonic anhydrase

1983 • 78 citations

On the Interaction of Bovine Cobalt Carbonic Anhydrase with Sulfonamides

1968 • 70 citations

Phenol, a competitive inhibitor of CO2 hydration catalyzed by carbonic anhydrase

1982 • 68 citations

Inhibition and Modification of Human Carbonic Anhydrase B with Bromoacetate and Iodoacetamide

1970 • 49 citations

Investigation of the mechanism of ligand binding with cobalt(II) human carbonic anhydrase by hydrogen-1 and fluorine-19 nuclear magnetic resonance spectroscopy

1971 • 49 citations

Metal coordination geometry and mode of action of carbonic anhydrase. Effect of imidazole on the spectral properties of Co(II) and111Cd(II) human carbonic anhydrase B

1977 • 43 citations

A nuclear‐magnetic‐resonance study of the binding of novel <scp>N</scp>‐hydroxybenzenesulphonamide carbonic anhydrase inhibitors to native and cadmium‐111‐substituted carbonic anhydrase

1985 • 40 citations

Kinetics of carbonic anhydrase-inhibitor complex formation. Comparison of anion- and sulfonamide-binding mechanisms

1971 • 40 citations

Effects of two ionizing groups on the active site of human carbonic anhydrase B.

1976 • 33 citations

The inhibition of human carbonic anhydrase II by some organic compounds

1985 • 32 citations

Histidine-200 alters inhibitor binding in human carbonic anhydrase B. A carbon-13 nuclear magnetic resonance identification

1977 • 31 citations

Binding affinity of bicarboxylate ions for cobalt(II) bovine carbonic anhydrase

1978 • 29 citations

Interaction of the unique competitive inhibitor imidazole with human carbonic anhydrase B

1977 • 27 citations

Interaction of cobalt(II) bovine carbonic anhydrase with pyridine-2,6-dicarboxylate ion and other chelating ligands

1980 • 25 citations

Monocarboxamidomethyl Carbonic Anhydrase Purified by Affinity Chromatography

1973 • 22 citations

A new class of inhibitors capable of binding both the acidic and alkaline forms of carbonic anhydrase

1981 • 19 citations

Interaction of bovine carbonic anhydrase with (neutral) aniline, phenol, and methanol

1980 • 19 citations