Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

1991 • 950 citations

Tumor tissue oxygenation as evaluated by computerized-po2-histography

1990 • 255 citations

Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects

1988 • 220 citations

Intratumoral oxygen pressure in malignant brain tumor

1991 • 115 citations

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-l,2,4-benzotriazine-l ,4-dioxide (SR 4233, WIN 59075) by mouse liver

1992 • 78 citations

Enzymology of the reductive bioactivation of SR 4233

1990 • 69 citations

Keynote address: Bioreductive mechanisms

1992 • 69 citations

Identification of human cytochromes P-450 analogous to forms induced by phenobarbital and 3-methylcholanthrene in the rat

1985 • 60 citations

Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.

1993 • 33 citations

The role of positron emission tomography in the study of cerebral tumors.

1986 • 33 citations

Po<sub>2</sub> Distribution in Tumor Tissue of DS-Carcinosarcoma

1974 • 31 citations

Initial characterization of the major mouse cytochrome p450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-Amino-1,2,4-Benzotriazine-1,4-di-N-Oxide (Tirapazamine, SR 4233, Win 59075)

1993 • 30 citations

Second-generation 1,2,4-benzotriazine 1,4-di-N-oxide bioreductive anti-tumor agents: Pharmacology and activity in vitro and in vivo

1992 • 26 citations

The levels of quinone reductases, superoxide dismutase and glutathione-related enzymatic activities in diethylstilbestrol-induced carcinogenesis in the kidney of male Syrian golden hamsters

1990 • 25 citations

Keynote address: Bioreductive therapy

1992 • 7 citations

Measuring the pO2 Time Behaviour in Tumours as a Valuable Tool in Cancer Therapy

1974 • 5 citations