Effects of reoxygenation on cells from hypoxic regions of solid tumors: analysis of transplanted murine tumors for evidence of DNA overreplication.

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

1968 • 764 citations

Intermittent blood flow in a murine tumor: radiobiological effects.

1987 • 440 citations

Tumor hypoxia: its impact on cancer therapy

1987 • 410 citations

Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells.

1988 • 380 citations

Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.

1981 • 339 citations

Acute hypoxia in tumors: Implications for modifiers of radiation effects

1986 • 267 citations

Model for the genetic evolution of human solid tumors.

1989 • 251 citations

Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells.

1986 • 251 citations

Hypoxia in Tumors: A Paradigm for the Approach to Biochemical and Physiologic Heterogeneity

1988 • 246 citations

Cytotoxicity, Mutagenicity and DNA damage by Hoechst 33342.

1982 • 240 citations

Gene amplification in a single cell cycle in Chinese hamster ovary cells.

1984 • 190 citations

The use of fluorescent probes to identify regions of transient perfusion in murine tumors

1989 • 173 citations

The effect of environmental pH on the growth of normal and malignant cells

1973 • 160 citations

TUMOUR CELL PROLIFERATION IN RELATION TO THE VASCULATURE

1979 • 143 citations

Vascular occlusion and tumour cell death

1983 • 142 citations

Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumours

1985 • 137 citations

Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors.

1986 • 130 citations

An in Vitro Assay to Measure the Viability of KHT Tumor Cells Not Previously Exposed to Culture Conditions

1974 • 126 citations

Cell selection from a murine tumour using the fluorescent probe Hoechst 33342

1985 • 120 citations

Effects of Reoxygenation on Cells From Hypoxic Regions of Solid Tumors: Anticancer Drug Sensitivity and Metastatic Potential

1990 • 119 citations

Validation of the fluorescent dye Hoechst 33342 as a vascular space marker in tumours

1988 • 111 citations

Influence of tumour size on hypoxic fraction and therapeutic sensitivity of Lewis lung tumour

1977 • 95 citations

Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance.

1987 • 91 citations

pH distributions in spontaneous and isotransplanted rat tumours

1988 • 80 citations

Evaluation of a modeling system for S-phase estimation in breast cancer by flow cytometry.

1987 • 70 citations

Cell cycle regulation by environmental pH

1984 • 67 citations

The effect of prolonged hypoxia on growth and viability of Chinese hamster cells

1976 • 62 citations

Oxygen dependent regulation of DNA synthesis and growth of Ehrlich ascites tumor cells in vitro and in vivo.

1988 • 57 citations

Intracapillary HbO2 saturations in murine tumours and human tumour xenografts measured by cryospectrophotometry: relationship to tumour volume, tumour pH and fraction of radiobiologically hypoxic cells

1988 • 56 citations

Cell killing, radiosensitization and cell cycle redistribution induced by chronic hypoxia

1984 • 53 citations

DNA damage, cytotoxic effect and cell‐cycle perturbation of Hoechst 33342 on L1210 cells in vitro

1988 • 51 citations

5-fluorouracil infusions and fractionated doses of radiation: Studies with a murine squamous cell carcinoma

1987 • 50 citations

Cryospectrophotometric Determination of Tumor Intravascular Oxyhemoglobin Saturations: Dependence on Vascular Geometry and Tumor Growth

1988 • 50 citations

Over-replication of DNA in S phase Chinese hamster ovary cells after DNA synthesis inhibition.

1987 • 49 citations

Regrowth and radiation sensitivity of quiescent cells isolated from EMT6/Ro-fed plateau monolayers.

1985 • 43 citations

Radiation sensitivity of tumour cells stained in vitro or in vivo with the bisbenzimide fluorochrome Hoechst 33342

1989 • 41 citations

Dynamic heterogeneity: isolation of murine tumor cell populations enriched for metastatic variants and quantification of the unstable expression of the phenotype

1986 • 39 citations

A New Method of Determining the Fraction of Hypoxic Cells in a Transplantable Murine Sarcoma

1977 • 39 citations

Restimulation of cell cycle progression by hypoxic tumour cells with deoxynucleosides requires ppm oxygen tension*1

1987 • 33 citations

Dose fractionation studies with a murine sarcoma under conditions of air or carbogen (95% OI2 + 5% CO2) breathing

1977 • 27 citations

Characterization of radiation resistant hypoxic cell subpopulations in KHT sarcomas. (ii) Cell sorting

1988 • 26 citations

In situradiation response and oxygen enhancement ratio of KHT sarcoma cells in various phases of the cell cycle

1984 • 20 citations

Development of tetraploidy in V79 spheroids

1982 • 20 citations

Slowing of cell cycle traverse for cells in exponential monolayer cultures placed into plateau-fed and starved medium.

1989 • 14 citations

Absence of DNA overreplication in Chinese hamster cells incubated with inhibitors of DNA synthesis.

1987 • 9 citations

No significant overreplication occurs in Ehrlich ascites cells during and after reversal of hypoxia

1989 • 6 citations