The detection and measurement of hypoxic cells in solid tumors

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

1953 • 2,102 citations

Hypoxic fractions of solid tumors: Experimental techniques, methods of analysis, and a survey of existing data

1984 • 610 citations

Definitive evidence for hypoxic cells influencing cure in cancer therapy.

1978 • 422 citations

RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER

1977 • 321 citations

Radiation and High-Dose Metronidazole in Supratentorial Glioblastomas

1976 • 309 citations

A marker for hypoxic cells in tumours with potential clinical applicability

1981 • 309 citations

Clinical testing of the radiosensitizer Ro 07-0582: Experience with multiple doses

1977 • 264 citations

Radiation sensitizers, their use in the clinical management of cancer

1980 • 259 citations

Electron Affinic Sensitization: V. Radiosensitization of Hypoxic Bacteria and Mammalian Cells in Vitro by Some Nitroimidazoles and Nitropyrazoles

1974 • 229 citations

A Multicomponent X-ray Survival Curve for Mouse Lymphosarcoma Cells irradiated in vivo

1963 • 224 citations

Quantitative measurements of oxygen tension in normal tissues and in the tumours of patients before and after radiotherapy

1960 • 222 citations

Hypoxic Sensitizers — Implications for Radiation Therapy

1979 • 209 citations

Hypoxic Sensitizers: Radiobiological Studies at the Cellular Level

1975 • 205 citations

Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo.

1976 • 195 citations

Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells.

1983 • 187 citations

Selective chemotherapy of noncycling cells in an in vitro tumor model.

1974 • 170 citations

CHEMICAL RADIOSENSITIZATION OF HYPOXIC CELLS

1973 • 166 citations

Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla.

1984 • 160 citations

In vivo ³¹ P NMR study of the metabolism of murine mammary 16/C adenocarcinoma and its response to chemotherapy, x-radiation, and hyperthermia

1983 • 139 citations

Intracapillary oxyhemoglobin saturation of malignant tumors in humans

1981 • 131 citations

Selective Radiosensitization of the Hypoxic Cells of Mouse Tumors with the Nitroimidazoles Metronidazole and Ro 7-0582

1975 • 128 citations

Studies on the Toxicity and Radiosensitizing Ability of Misonidazole under Conditions of Prolonged Incubation

1978 • 127 citations

Inactivation of Mammalian Cells after Disintegrations of³H or¹²⁵I in Cell DNA at −196°C

1973 • 125 citations

Effect of Oxygen and Nitric Oxide on the Radiosensitivity of Human Cells in Tissue Culture

1960 • 122 citations

Clinical Phase I Study of the Hypoxic Cell Radiosensitizer RO-07-0582, A 2-Nitroimidazole Derivative

1977 • 116 citations

Tests of Two Electron-Affinic Radiosensitizers in Vivo Using Regrowth of an Experimental Carcinoma

1975 • 115 citations

Biological Bases and Clinical Implications of Tumor Radioresistance

1980 • 91 citations

Peripheral neuropathy related to misonidazole: incidence and pathology.

1978 • 91 citations

A Thin-Film Culturing Technique Allowing Rapid Gas-Liquid Equilibration (6 Sec) with No Toxicity to Mammalian Cells

1984 • 88 citations

The labelling of EMT-6 tumours in BALB/C mice with¹⁴C-misonidazole

1983 • 80 citations

Radiation-Induced Events and Their Time Scale in Mammalian Cells

1981 • 74 citations

In vivotesting of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique

1975 • 73 citations

Measurement of self-renewal in culture of clonogenic cells from human ovarian carcinoma

1981 • 65 citations

Binding of 14C-misonidazole to hypoxic cells in V79 spheroids

1982 • 64 citations

Nuclear magnetic resonance imaging in medicine

1981 • 63 citations

Human tumors as examined by in vivo 31P NMR in athymic mice

1982 • 63 citations

Fluorescent nitroheterocycles for identifying hypoxic cells.

1983 • 60 citations

Accomplishments in cancer research, 1984

1987 • 57 citations

Intracellular localization of radioactively labeled misonidazole in EMT-6 tumor cells in vitro

1982 • 56 citations

Clinical trials of hypoxic cell sensitizers

1982 • 55 citations

Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia

1979 • 48 citations

Radiation Chemical Studies with Nitrofurazone as Related to Its Mechanism of Radiosensitization

1973 • 47 citations

Tumour oxygenation under normobaric and hyperbaric conditions

1983 • 46 citations

Regional [14C]misonidazole distribution in experimental RT-9 brain tumors.

1983 • 39 citations

Advanced Topics on Radiosensitizers of Hypoxic Cells

1982 • 38 citations

Synthesis and In vivo studies of the radiosensitizer 4-[82Br]bromomisonidazole

1983 • 37 citations

Clinical trials of misonidazole in the United States.

1981 • 34 citations

Nitroheterocyclic drugs as selective radiosensitizers of hypoxic mammalian cells.

1974 • 33 citations

Kryomicrophotometry as a Method for Analyzing the Intracapillary HbO2 Saturation of Organs Under Different O2 Supply Conditions

1976 • 33 citations

Binding of misonidazole to EMT6 AND V79 spheroids

1982 • 32 citations

Detection of antineoplastic agent induced cardiotoxicity by 31P NMR of perfused rat hearts

1983 • 31 citations

Comparison of Oxygen Tensions in Normal Tissues and Yoshida Sarcoma of the Rat Breathing Air or Oxygen at 4 Atmospheres

1963 • 30 citations

Intracapillary HbO2 Saturation in Tumor Tissue of DS-Carcinosarcoma During Normoxia

1978 • 25 citations

Bromomisonidazole: Synthesis and Characterization of a New Radiosensitizer

1982 • 24 citations

EFFECT ON OXYGEN TENSION OF TUMOURS OF BREATHING OXYGEN AT HIGH PRESSURES

1962 • 21 citations

The application in radiation therapy of substances which modify cellular radiation response

1977 • 17 citations

Electron-affinic compounds for labelling hypoxic cells: the synthesis and characterization of 1-[2-(2-iodophenoxy)-ethyl]-2-nitroimidazole.

1984 • 13 citations

Electron-Affillic Compounds for Labelling Hypoxie Cells : The Synthesis and Characterization of 1-[2-(2-Iodophenoxy)-Ethyl]-2-Nitroimidazole

1984 • 11 citations

Radiation-Induced and Metabolism-Induced Reactions of Hypoxic Sensitizers with Cellular Molecules

1982 • 5 citations

Nuclear Magnetic Resonance Imaging in Medicine

1983 • 2 citations