Poly(ADP-ribose) polymerase: Structure-function relationship

Role of poly(ADP-ribose) formation in DNA repair

1992 • 1,142 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

DNA polymerase fidelity and the polymerase chain reaction.

1991 • 441 citations

ADP-ribosylation of proteins. Enzymology and biological significance.

1987 • 374 citations

Molecular and biochemical features of poly (ADP-ribose) metabolism

1993 • 300 citations

High level expression of nonfused foreign genes with Autographa californica nuclear polyhedrosis virus expression vectors

1989 • 300 citations

The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.

1990 • 271 citations

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

1993 • 242 citations

Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.

1984 • 226 citations

ADP-Ribose in DNA Repair: A New Component of DNA Excision Repair

1984 • 226 citations

Signals important for high-level expression of foreign genes in Autographa californica nuclear polyhedrosis virus expression vectors

1988 • 204 citations

Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA

1989 • 192 citations

NAD(+)-dependent repair of damaged DNA by human cell extracts.

1993 • 191 citations

Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.

1992 • 171 citations

Poly(ADP-ribosylation) of a DNA topoisomerase.

1983 • 145 citations

ADP-ribosylation reactions

1995 • 127 citations

PCR: Methods and applications

1993 • 117 citations

Conformational Analysis of a 139 Base-pair DNA Fragment Containing a Single-stranded Break and Its Interaction with Human Poly(ADP-ribose) Polymerase

1994 • 109 citations

The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity.

1992 • 107 citations

Poly(ADP-ribose) polymerase auto-modification and interaction with DNA: electron microscopic visualization.

1983 • 101 citations

Inhibition of poly(ADP-ribosyl)ation by overexpressing the poly(ADP-ribose) polymerase DNA-binding domain in mammalian cells.

1990 • 100 citations

Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity.

1990 • 85 citations

Down-regulation of topoisomerase I in mammalian cells following ionizing radiation.

1994 • 83 citations

ADP-Ribosylation Reactions

1992 • 81 citations

Identification of potential active-site residues in the human poly(ADP-ribose) polymerase.

1993 • 79 citations

Poly(ADP-ribose)-mediated post-translational modification of chromatin-associated human topoisomerase I

1989 • 76 citations

Poly(ADP-ribose) polymerase stimulates DNA polymerase alpha by physical association.

1993 • 69 citations

The carboxyl-terminal domain of human poly(ADP-ribose) polymerase. Overproduction in Escherichia coli, large scale purification, and characterization

1993 • 64 citations

Influence of poly(ADP-ribose) polymerase on the enzymatic synthesis of SV40 DNA.

1991 • 64 citations

Overproduction and large-scale purification of the human poly(ADP-ribose) polymerase using a baculovirus expression system

1992 • 62 citations

Detection of poly(ADP ribose) polymerase in crude extracts by activity-blot

1991 • 57 citations

Mutant cells defective in poly(ADP-ribose) synthesis due to stable alterations in enzyme activity or substrate availability

1989 • 54 citations

Crystallization and X-ray Crystallogragphic Analysis of Recombinant Chicken Poly (ADP-ribose) Polymerase Catalytic Domain Produced in Sf9 Insect Cells

1994 • 26 citations

In vivo characterization of the poly(ADP-ribosylation) of SV40 chromatin and large T antigen by immunofractionation

1987 • 19 citations

Different oligosaccharide processing of the membrane-integrated and the secretory form of gp 80 in rat liver.

1986 • 18 citations

Directed Mutagenesis of Glutamic Acid 988 of Poly(ADP-ribose) Polymerase

1992 • 9 citations