Cellular Mechanisms of Resistance to Chronic Oxidative Stress

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Methods of Enzymatic Analysis

1975 • 20,446 citations

Free radicals in biology and medicine

1991 • 17,840 citations

Glutathione S-Transferases

1974 • 17,321 citations

Superoxide Dismutase

1969 • 12,578 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

GLUTATHIONE

1983 • 5,487 citations

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Free radicals in biology and medicine

1985 • 2,999 citations

[44] Glutathione peroxidase

1981 • 2,990 citations

[59] Glutathione reductase

1985 • 2,854 citations

Handbook of methods for oxygen radical research

1987 • 2,395 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

1983 • 1,808 citations

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1988 • 1,699 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

1995 • 1,453 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1994 • 1,120 citations

Role of amino acid transport and countertransport in nutrition and metabolism.

1990 • 1,101 citations

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1989 • 987 citations

The Isoenzymes of Glutathione Transferase

1985 • 960 citations

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

1992 • 912 citations

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

1991 • 906 citations

Glutathione-Associated Enzymes In Anticancer Drug Resistance

2016 • 864 citations

Antioxidant activity of albumin-bound bilirubin.

1987 • 763 citations

Parkinson's disease: A disorder due to nigral glutathione deficiency?

1982 • 746 citations

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

1995 • 744 citations

Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.

1975 • 729 citations

Clonal cell lines from the rat central nervous system

1974 • 727 citations

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

1982 • 704 citations

Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases?

1994 • 701 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

GLUTATHIONE S-TRANSFERASES: GENE STRUCTURE, REGULATION, AND BIOLOGICAL FUNCTION

1989 • 624 citations

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

1994 • 588 citations

Oxidative damage to DNA: relation to species metabolic rate and life span.

1988 • 587 citations

Central nervous system trauma and strokeII. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation

1989 • 580 citations

Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention

1993 • 512 citations

Hyperthermia Protects Against Light Damage in the Rat Retina

1988 • 445 citations

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1990 • 424 citations

[1] Glutathione metabolism

1995 • 406 citations

Are reactive oxygen species involved in Alzheimer's disease?

1995 • 358 citations

Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line

1994 • 342 citations

The Role of Monoamine Metabolism in Oxidative Glutamate Toxicity

1996 • 335 citations

Transport of cystine and cysteine in mammalian cells

1984 • 329 citations

Conformationally defined neurotransmitter analogs. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer

1991 • 303 citations

Glutathione S-Transferases: Biomedical Applications

1993 • 286 citations

[62] Glutathione transferases from human liver

1985 • 281 citations

The stress protein response in cultured neurons: Characterization and evidence for a protective role in excitotoxicity

1991 • 279 citations

Transient hyperthermia protects against subsequent forebrain ischemic cell damage in the rat

1989 • 270 citations

[47] Glutathione biosynthesis; γ-glutamylcysteine synthetase from rat kidney

1985 • 266 citations

The Transport of Oxidized Glutathione from Human Erythrocytes

1969 • 256 citations

Evaluation of methods for measuring cellular glutathione content using flow cytometry

1994 • 245 citations

Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.

1989 • 245 citations

STEPS IN THE NEOPLASTIC TRANSFORMATION OF HAMSTER EMBRYO CELLS BY POLYOMA VIRUS

1963 • 243 citations

Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release.

1995 • 236 citations

Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis.

1983 • 232 citations

Expression of bcl‐2 inhibits necrotic neural cell death

1995 • 216 citations

Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action

1995 • 204 citations

Oxidative stress as a cause of Parkinson's disease

1991 • 203 citations

Heat shock protects cultured neurons from glutamate toxicity

1991 • 199 citations

Entamoeba histolytica : a Eukaryote Without Glutathione Metabolism

1984 • 189 citations

Alzheimer’s and Parkinson’s disease

1991 • 186 citations

Evolution of Glutathione Metabolism

1991 • 182 citations

Glutathione Depletion Induces Heme Oxygenase‐1 (HSP32) mRNA and Protein in Rat Brain

1993 • 180 citations

Uptake of Glutamate and Cystine in C‐6 Glioma Cells and in Cultured Astrocytes

1990 • 179 citations

Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)

1983 • 177 citations

Glutathione S-transferases and carcinogenesis

1987 • 170 citations

Gluthathione transferases: A possible role in the detoxication and repair of DNA and lipid hydroperoxides

1989 • 168 citations

Growth factors and vitamin E modify neuronal glutamate toxicity.

1992 • 167 citations

gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells.

1994 • 163 citations

Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.

1996 • 163 citations

Structure, expression and function of a schwannoma-derived growth factor

1990 • 153 citations

Glutathione metabolism in the lung: inhibition of its synthesis leads to lamellar body and mitochondrial defects.

1989 • 153 citations

Cystine Uptake and Glutathione Level in Fetal Brain Cells in Primary Culture and in Suspension

1993 • 148 citations

Glutathione S-transferase isoenzymes in rat brain neurons and glia

1993 • 147 citations

Induction and expression of long- and short-term neurosecretory potentiation in a neural cell line

1990 • 143 citations

[74] Methods for the selective modification of glutathione metabolism and study of glutathione transport

1985 • 131 citations

Contrasts in transport systems for anionic amino acids in hepatocytes and a hepatoma cell line HTC.

1982 • 131 citations

Transport of cystine and cysteine and cell growth in cultured human diploid fibroblasts: Effect of glutamate and homocysteate

1982 • 130 citations

Increased antioxidant enzyme activity in amyloid beta protein-resistant cells

1996 • 128 citations

Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits.

1993 • 128 citations

Glutathione and protein thiol homeostasis in brain during reperfusion after cerebral ischemia.

1995 • 119 citations

Active oxygen induced DNA strand breakage and poly ADP-ribosylation in promotable and non-promotable JB6 mouse epidermal cells

1988 • 119 citations

The Effect of Aging on Glutathione and Cysteine Levels in Different Regions of the Mouse Brain

1989 • 110 citations

Cysteinesulfinate metabolism. altered partitioning between transamination and decarboxylation following administration of beta-methyleneaspartate.

1983 • 107 citations

Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons.

1996 • 106 citations

Bcl-2 Prevents Killing of Neuronal Cells by Glutamate but Not by Amyloid β Protein

1993 • 98 citations

Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan.

1995 • 97 citations

Up-regulation of glutathione synthesis in rat kidney by methyl mercury

1995 • 96 citations

Reversible conjugation of ethacrynic acid with glutathione and human glutathione S-transferase P1-1.

1994 • 82 citations

Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells

1997 • 82 citations

Oxidative stress: its role in the pathogenesis of amyotrophic lateral sclerosis

1995 • 75 citations

Increase in gamma-glutamylcysteine synthetase activity and steady-state messenger RNA levels in melphalan-resistant DU-145 human prostate carcinoma cells expressing elevated glutathione levels.

1992 • 75 citations

Increased capacity for glutathione synthesis enhances resistance to radiation in Escherichia coli: a possible model for mammalian cell protection.

1989 • 73 citations

Detoxification of DNA hydroperoxide by glutathione transferases and the purification and characterization of glutathione transferases of the rat liver nucleus

1988 • 73 citations

Amyloid β Toxicity Consists of a Ca²⁺‐Independent Early Phase and a Ca²⁺‐Dependent Late Phase

1996 • 73 citations

Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells

1991 • 71 citations

Glutathione S-transferases and gamma-glutamyl transpeptidase in the rat nervous systems: a basis for differential susceptibility to neurotoxicants.

1995 • 62 citations

Oxidative damage to DNA

1995 • 58 citations

Oxidative stress, age-related neurodegeneration, and the potential for neurotrophic treatment.

1995 • 57 citations

The conjugation of prostaglandin A1 and glutathione catalyzed by homogeneous glutathione S-transferases from human and rat liver

1975 • 56 citations

Thymine hydroperoxide, a substrate for rat Se‐dependent glutathione peroxidase and glutathione transferase isoenzymes

1986 • 56 citations

[15] 1,3-Bis(2-chloroethyl)-1-nitrosourea as Thiol-carbamoylating agent in biological Systems

1995 • 51 citations

The initial-rate kinetics of mouse glutathione S-transferase YfYf. Evidence for an allosteric site for ethacrynic acid

1991 • 48 citations

Contribution of increased glutathione content to mechanisms of oxidative stress resistance in hydrogen peroxide resistant hamster fibroblasts

1995 • 47 citations

Specificity of isozymes of murine hepatic glutathione S-transferase for the conjugation of glutathione with L-phenylalanine mustard.

1991 • 47 citations

Glutathione Transferases and Carcinogenesis

1986 • 46 citations

A role for gamma‐glutamyl transpeptidase and the amino acid transport system xc‐ in cystine transport by a human pancreatic duct cell line.

1995 • 45 citations

Inactivation of mouse liver glutathione S-transferase YfYf (Pi class) by ethacrynic acid and 5,5′-dithiobis-(2-nitrobenzoic acid)

1993 • 35 citations

Regulation of Lipid Peroxidation by Glutathione and Lipoic Acid: Involvement of Liver Microsomal Vitamin E Free Radical Reductase

1990 • 35 citations

Markedly Decreased Expression of Glutathione S-Transferase π Gene in Human Cancer Cell Lines Resistant to Buthionine Sulfoximine, an Inhibitor of Cellular Glutathione Synthesis

1995 • 33 citations

Anticancer Drug Resistance

1994 • 32 citations

[7] Measurement of γ-glutamyl transpeptidase and γ-glutamylcysteine synthetase activities in cells

1995 • 28 citations

Enhanced glutathione peroxidase expression protects cells from hydroperoxides but not from radiation or doxorubicin.

1995 • 28 citations

[10] Cystathionine

1995 • 21 citations

Glutathione reductase in human and murine lung tumors: high levels of mRNA and enzymatic activity.

1993 • 18 citations

Mechanisms of resistance to alkylating agents

1994 • 14 citations

Increased oxidant resistance of alveolar macrophages isolated from rats repeatedly exposed to cadmium aerosols

1996 • 9 citations

Influence of aging on the acute depletion of reduced glutathione induced by electrophilic agents

1991 • 9 citations