Oxidative damage to DNA

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

The Chemical Basis of Radiation Biology

1987 • 1,843 citations

The chemical basis of radiation biology

1987 • 1,788 citations

Purine bases, nucleosides, and nucleotides: aqueous solution redox chemistry and transformation reactions of their radical cations and e- and OH adducts

1989 • 1,215 citations

Oxidative Stress: Oxidants and Antioxidants.

1992 • 1,193 citations

Mutagenesis by 8-oxoguanine: an enemy within

1993 • 805 citations

Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.

1989 • 733 citations

Endogenous mutagens and the causes of aging and cancer

1991 • 725 citations

Hydroxyl Free Radical Adduct of Deoxyguanosine: Sensitive Detection and Mechanisms of Formation

1986 • 660 citations

New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase.

1994 • 337 citations

2,2-Diamino-4-[(3,5-di-O-acetyl-2-deoxy-.beta.-D-erythro- pentofuranosyl)amino]-5-(2H)-oxazolone: a Novel and Predominant Radical Oxidation Product of 3',5'-Di-O-acetyl-2'-deoxyguanosine

1994 • 337 citations

Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA.

1994 • 321 citations

Bioorganic Photochemistry

1991 • 317 citations

[2] Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection

1994 • 303 citations

Photosensitized formation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) in DNA by riboflavin: a nonsinglet oxygen-mediated reaction

1992 • 295 citations

Endogenous DNA adducts: Potential and paradox

1993 • 284 citations

Endogenous oxidative damage of deoxycytidine in DNA.

1992 • 280 citations

Pattern of hydroxyl radical addition to uracil and methyl- and carboxyl-substituted uracils. Electron transfer of hydroxyl adducts with N,N,N',N'-tetramethyl-p-phenylenediamine and tetranitromethane

1981 • 279 citations

Commentary the Measurement of Oxidative Damage to DNA by HPLC and GC/MS Techniques

1992 • 242 citations

Reaction of Singlet Oxygen with 2'-Deoxyguanosine and DNA. Isolation and Characterization of the Main Oxidation Products

1995 • 179 citations

Yields of Radiation-induced Base Products in DNA: Effects of DNA Conformation and Gassing Conditions

1990 • 168 citations

Quantitative determination of oxidative base damage in DNA by stable isotope‐dilution mass spectrometry

1993 • 153 citations

New trends in photobiology

1993 • 146 citations

Thymine Fragment Damage Retained in the DNA Polynucleotide Chain after Gamma Irradiation in Aerated Solutions. II

1977 • 127 citations

Mechanism of OH radical reactions with thymine and uracil derivatives

1986 • 126 citations

Quantitative Measurement of Radiation-Induced Base Products in DNA Using Gas Chromatography-Mass Spectrometry

1989 • 123 citations

5-Formyldeoxyuridine: a new type of DNA damage induced by ionizing radiation and its mutagenicity to Salmonella strain TA102

1990 • 114 citations

Quantitative high-performance liquid chromatography analysis of DNA oxidized in vitro and in vivo

1991 • 113 citations

Sensitized Photo-oxidation of Thymidine by 2-methyl-1,4-naphthoquinone. Characterization of the Stable Photoproducts

1986 • 108 citations

Oxidative Processes and Antioxidants

1995 • 100 citations

Thymidine Hydroperoxides: Structural Assignment, Conformational Features, and Thermal Decomposition in Water

1994 • 99 citations

QUINONE SENSITIZED ELECTRON TRANSFER PHOTOOXIDATION OF NUCLEIC ACIDS: CHEMISTRY OF THYMINE AND THYMIDINE RADICAL CATIONS IN AQUEOUS SOLUTION*

1990 • 94 citations

Synthesis of the diastereomers of thymidine glycol, determination of concentrations and rates of interconversion of theircis-transepimers at equilibrium and demonstration of differential alkali lability within DNA

1992 • 86 citations

[8] Singlet oxygen DNA damage: Chromatographic and mass spectrometric analysis of damage products

1994 • 70 citations

Detecting DNA damage

1993 • 65 citations

Oxygen Uptake in the Radiolysis of Aqueous Solutions of Nucleic Acids and Their Constituents

1982 • 63 citations

Isomerization and new specific synthesis of thymine glycol

1975 • 59 citations

[52] Photodynarnic methods for oxy radical-induced DNA damage

1990 • 58 citations

Specific Deprotonation Reactions of the Pyrimidine Radical Cation Resulting from the Menadione Mediated Photosensitization of 2′-Deoxycytidine

1987 • 55 citations

Proton magnetic resonance studies of 5,6-saturated thymidine derivatives produced by ionizing radiation. Conformational analysis of 6-hydroxylated diastereoisomers

1979 • 54 citations

Radical oxidation reaction of the purine moiety of 2′-deoxyribonucleosides and DNA by iron-containing minerals

1993 • 53 citations

Quantitative Measurement of the Diastereoisomers of CIS Thymidine Glycol in Gamma-Irradiated DNA

1987 • 50 citations

Photooxidation of d(TpG) by phthalocyanines and riboflavin. Isolation and characterization of dinucleoside monophosphates containing the 4R^*and 4S^*d iastereoisomers of 4,8-di hyd ro-4-hydroxy-8-oxo-2′-deoxyguanosine

1992 • 49 citations

Phosphorus-32 postlabeling measurement of adenine N-1-oxide in cellular DNA exposed to hydrogen peroxide

1990 • 47 citations

Chemical and biochemical postlabeling methods for singling out specific oxidative DNA lesions

1992 • 42 citations

Ionic and radical oxidations of DNA by hydrogen peroxide

1991 • 38 citations

A ¹H and ¹³C nmr study of the radiation-induced degradation products of 2′-deoxythymidine derivatives: N-(2′-deoxy-β-<scp>D</scp>-erythropentofuranosyl) formamide

1981 • 37 citations

Formation of 5-hydroxymethyl-2′-deoxyuridine in hepatic DNA of rats treated with γ-irradiation, diethylnitrosamine, 2-acetylaminofluorene or the peroxisome proliferator ciprofibrate

1990 • 34 citations

BENZOPHENONE PHOTOSENSITIZATION OF 2'-DEOXYGUANOSINE: CHARACTERIZATION OF THE 2R AND 2s DIASTEREOISOMERS OF 1-(2-DEOXY-β-D-erythoW-PENTOFURANOSYL)-2-METHOXY-4,5-IMIDAZOLIDINEDIONE. A MODEL SYSTEM FOR THE INVESTIGATION OF PHOTOSENSITIZED FORMATION OF DNA-PROTEIN CROSSLINKS

1994 • 33 citations

Gas chromatographic—mass spectrometric determination of 5-hydroxymethyluracil in human urine by stable isotope dilution

1993 • 30 citations

Incorporation by chemical synthesis and characterization of deoxyribosylformylamine into DNA

1991 • 25 citations

Methods used for analyses of “environmentally” damaged nucleic acids

1993 • 24 citations

Analysis of thymidine hydroperoxides by post-column reaction high-performance liquid chromatography

1990 • 18 citations

Measurement of oxidized nucleobases and nucleosides in human urine by using a GC/MS assay in the selective ion monitoring mode

1995 • 4 citations

Some aspects of radiation-induced free-radical chemistry of biologically important molecules

1992 • 3 citations

Deleted Work

1955 • 0 citations