Glutathione Depletion Induces Heme Oxygenase‐1 (HSP32) mRNA and Protein in Rat Brain

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Current protocols in molecular biology

1988 • 7,584 citations

GLUTATHIONE

1983 • 5,487 citations

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Oxygen Radicals and Human Disease

1987 • 1,854 citations

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1988 • 1,699 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Heat shock proteins.

1990 • 1,365 citations

Microsomal Heme Oxygenase

1969 • 1,348 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices

1989 • 912 citations

Antioxidant activity of albumin-bound bilirubin.

1987 • 763 citations

Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

1986 • 748 citations

Biological Roles of Nitric Oxide

1992 • 731 citations

Cloning and expression of cDNA for rat heme oxygenase.

1985 • 451 citations

Mouse actin messenger RNAs. Construction and characterization of a recombinant plasmid molecule containing a complementary DNA transcript of mouse alpha-actin mRNA.

1981 • 438 citations

A fluorometric assay for glutathione

1966 • 436 citations

Does carbon monoxide have a physiological function?

1991 • 425 citations

Enzyme-Activated Irreversible Inhibitors

1979 • 420 citations

Transcriptional control of rat heme oxygenase by heat shock.

1987 • 415 citations

Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

1989 • 414 citations

The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin.

1970 • 396 citations

Purification and characterization of biliverdin reductase from rat liver.

1981 • 298 citations

Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects.

1991 • 291 citations

Evidence suggesting that the two forms of heme oxygenase are products of different genes.

1988 • 288 citations

Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein.

1991 • 267 citations

Cobalt Induction of Hepatic Heme Oxygenase; with Evidence That Cytochrome P -450 Is Not Essential for This Enzyme Activity

1974 • 261 citations

Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform.

1986 • 260 citations

Histochemical evaluation of glutathione in brain

1987 • 253 citations

Mechanisms of Heat-Shock Gene Activation in Higher Eukaryotes

1987 • 240 citations

Normal and Heat‐Induced Patterns of Expression of Heme Oxygenase‐1 (HSP32) in Rat Brain: Hyperthermia Causes Rapid Induction of mRNA and Protein

1992 • 195 citations

Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress.

1991 • 194 citations

In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: Differential distribution of isozyme 1 and 2

1992 • 191 citations

Induction of heat shock (stress) genes in the mammalian brain by hyperthermia and other traumatic events: A current perspective

1990 • 170 citations

Developmental expression of heme oxygenase isozymes in rat brain. Two HO-2 mRNAs are detected.

1990 • 166 citations

The human 32‐kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase

1989 • 163 citations

Transport of gamma-glutamyl amino acids: role of glutathione and gamma-glutamyl transpeptidase.

1979 • 159 citations

Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2.

1990 • 147 citations

Light and electron microscopic demonstration of guanylate cyclase in rat brain

1983 • 143 citations

Multiplicity of Heme Oxygenase Isozymes

1989 • 116 citations

Resolution of the rat brain heme oxygenase activity: Absence of a detectable amount of the inducible form (HO-1)

1988 • 105 citations

Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells

1991 • 71 citations

Interrelationship of the distribution of neuropeptides and tyrosine hydroxylase immunoreactivity in the human substantia nigra

1989 • 59 citations

Regional distribution of the enzymes of haem biosynthesis and the inhibition of 5-aminolaevulinate synthase by manganese in the rat brain

1980 • 57 citations

Role of glutathione and hsp 70 in the acquisition of thermotolerance in postimplantation rat embryos

1991 • 45 citations

Enhancement and inhibition of enzymes of heme metabolism by diethyl maleate in the rat kidney

1982 • 19 citations

Deleted Work

1955 • 0 citations