Folic acid and colorectal cancer prevention: Molecular mechanisms and epidemiological evidence (Review)

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The risk of colorectal cancer in ulcerative colitis: a meta-analysis

2001 • 2,788 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

Long-Term Risk of Colorectal Cancer after Excision of Rectosigmoid Adenomas

1992 • 1,078 citations

DNA methylation in health and disease

2000 • 1,055 citations

5, 10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HuGE Review

2000 • 1,041 citations

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status

2002 • 918 citations

Folic Acid: Nutritional Biochemistry, Molecular Biology, and Role in Disease Processes

2000 • 782 citations

The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification.

2001 • 670 citations

Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms

2003 • 583 citations

Mechanisms of human DNA repair: an update

2003 • 572 citations

Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel disease

2003 • 552 citations

A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.

1996 • 525 citations

Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines

1999 • 475 citations

Epidemiologic Studies of Folate and Colorectal Neoplasia: a Review

2002 • 456 citations

Monoclonal antibodies to target epidermal growth factor receptor–positive tumors

2002 • 453 citations

Polymorphisms in Genes Involved in Folate Metabolism and Colorectal Neoplasia: A HuGE Review

2004 • 449 citations

Quantifying the effect of folic acid

2001 • 441 citations

Targeting the epidermal growth factor receptor for cancer therapy.

2002 • 412 citations

Folate Status: Effects on Pathways of Colorectal Carcinogenesis

2002 • 392 citations

Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene.

2000 • 390 citations

Periconceptional supplementation with folate and/or multivitamins for preventing neural tube defects

2001 • 385 citations

Role of Folate in Colon Cancer Development and Progression

2003 • 379 citations

Genomic DNA methylation decreases in response to moderate folate depletion in elderly women

2000 • 375 citations

Methylenetetrahydrofolate reductase, diet, and risk of colon cancer.

1999 • 363 citations

Folate and DNA Methylation: A Mechanistic Link between Folate Deficiency and Colorectal Cancer?

2004 • 339 citations

Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene

1997 • 327 citations

Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells.

2000 • 306 citations

Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.

1995 • 304 citations

Methyl groups in carcinogenesis: effects on DNA methylation and gene expression.

1992 • 301 citations

CARRIER-MEDIATED MEMBRANE TRANSPORT OF FOLATES IN MAMMALIAN CELLS

1999 • 296 citations

Folate Intake and Carcinogenesis of the Colon and Rectum

1991 • 293 citations

DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro

1998 • 290 citations

A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer

2002 • 287 citations

DNA Methylation in Folate Deficiency: Use of CpG Methylase

1993 • 286 citations

Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study

2003 • 269 citations

Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review

2003 • 259 citations

DACH-LIGA Homocystein (German, Austrian and Swiss Homocysteine Society): Consensus Paper on the Rational Clinical Use of Homocysteine, Folic Acid and B-Vitamins in Cardiovascular and Thrombotic Diseases: Guidelines and Recommendations

2003 • 250 citations

Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice.

2000 • 241 citations

The Genetics of Colorectal Cancer

2002 • 237 citations

Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction?

1999 • 236 citations

Riboflavin as a Determinant of Plasma Total Homocysteine: Effect Modification by the Methylenetetrahydrofolate Reductase C677T Polymorphism

2000 • 235 citations

Folate Deficiency In Vitro Induces Uracil Misincorporation and DNA Hypomethylation and Inhibits DNA Excision Repair in Immortalized Normal Human Colon Epithelial Cells

2000 • 218 citations

Methylenetetrahydrofolate Reductase C677T Mutation, Plasma Homocysteine, and Folate in Subjects From Northern Italy With or Without Angiographically Documented Severe Coronary Atherosclerotic Disease: Evidence for an Important Genetic-Environmental Interaction

1998 • 213 citations

Alcohol and Nutrients in Relation to Colon Cancer in Middle-aged Adults

1993 • 205 citations

Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies

2004 • 205 citations

Colorectal cancer and folate status: a nested case-control study among male smokers.

1996 • 199 citations

Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting, methyl-deficient diets.

1989 • 190 citations

Folate Intake, Alcohol Consumption, Cigarette Smoking, and Risk of Colorectal Adenomas

1998 • 185 citations

The Relationship between Hypomethylation and CpG Island Methylation in Colorectal Neoplasia

2003 • 184 citations

Relationship between vitamin and calcium supplement use and colon cancer.

1997 • 176 citations

5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites.

2002 • 176 citations

Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia

2000 • 172 citations

A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma

1998 • 169 citations

Nutritional Status of Folate and Colon Cancer Risk

2001 • 166 citations

Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis

1993 • 150 citations

A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability

2002 • 145 citations

Relationship of Folate, Vitamin B-6, Vitamin B-12, and Methionine Intake to Incidence of Colorectal Cancers

2002 • 143 citations

The Relationship between Riboflavin and Plasma Total Homocysteine in the Framingham Offspring Cohort Is Influenced by Folate Status and the C677T Transition in the Methylenetetrahydrofolate Reductase Gene

2002 • 139 citations

Folic Acid Fortification Increases Red Blood Cell Folate Concentrations in the Framingham Study

2001 • 135 citations

Folate depletion impairs DNA excision repair in the colon of the rat

1998 • 130 citations

Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization.

1986 • 129 citations

Effects of folate supplementation on two provisional molecular markers of colon cancer: a prospective, randomized trial

2001 • 126 citations

Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps.

1995 • 126 citations

Alterations in expression and methylation of specific gene in livers of rats fed a cancer promoting methyl-deficient diet

1991 • 125 citations

Protection against cancer by wheat bran

1999 • 122 citations

Review

1998 • 110 citations

Dietary Intake of Fat, Fiber and Other Nutrients Is Related to the Use of Vitamin and Mineral Supplements in the United States: The 1992 National Health Interview Survey

1996 • 108 citations

Dietary folate and colorectal cancer

2002 • 107 citations

The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon

2003 • 106 citations

Cruciferous Vegetables, Mushrooms, and Gastrointestinal Cancer Risks in a Multicenter, Hospital-Based Case-Control Study in Japan

2003 • 101 citations

Diet and colorectal cancer prevention

2000 • 97 citations

Folate and the risk of colorectal, breast and cervix cancer: the epidemiological evidence

2001 • 93 citations

Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum

2001 • 90 citations

Epidemiological evidence for beta-carotene in prevention of cancer and cardiovascular disease.

1996 • 87 citations

The onset of oncogene hypomethylation in the livers of rats fed methyl-deficient, amino acid-defined diets

1992 • 86 citations

Mammary gland specific hEGF receptor transgene expression induces neoplasia and inhibits differentiation

2000 • 80 citations

Folate and colorectal neoplasia: relation between plasma and dietary markers of folate and adenoma recurrence

2004 • 76 citations

Folate and alcohol intakes: Related or independent roles in the adenoma‐carcinoma sequence?

1996 • 71 citations

Autonomous proliferation of colon cancer cells that coexpress transforming growth factor α and its receptor

1992 • 70 citations

Global and Gene-Specific Methylation Patterns in Cancer: Aspects of Tumor Biology and Clinical Potential

2002 • 61 citations

Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas

2000 • 60 citations

Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C→T) on plasma homocysteine, folate and vitamin B12 levels and its relationship to cardiovascular disease risk

2002 • 59 citations

Folic acid inhibition of EGFR-mediated proliferation in human colon cancer cell lines

1999 • 57 citations

Altersassoziierte Ver�nderungen im Vitamin-B 12 - und Fols�urestoffwechsel: Pr�valenz, �tiopathogenese und pathophysiologische Konsequenzen

2004 • 57 citations

Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas

2003 • 54 citations

Bioavailability of Folate from Processed Spinach in Humans

2000 • 54 citations

Methylenetetrahydrofolate reductase mutation (677C → T) negatively influences plasma homocysteine response to marginal folate intake in elderly women

2000 • 53 citations

Effect of folate supplementation on mucosal cell proliferation in high risk patients for colon cancer

2002 • 52 citations

Organic Acids in Selected Foods Inhibit Intestinal Brush Border Pteroylpolyglutamate Hydrolase in Vitro: Potential Mechanism Affecting the Bioavailability of Dietary Polyglutamyl Folate

1998 • 47 citations

Folic Acid, 5-Methyl-Tetrahydrofolate and 5-Formyl-Tetrahydrofolate Exhibit Equivalent Intestinal Absorption, Metabolism and in Vivo Kinetics in Rats

1992 • 45 citations

Targeting epidermal growth factor receptor signaling: early results and future trends in oncology.

2003 • 44 citations

Chemoprevention of colorectal cancer in ulcerative colitis

2003 • 44 citations

The Glutamate Carboxypeptidase Gene II (C>T) Polymorphism Does Not Affect Folate Status in The Framingham Offspring Cohort

2002 • 44 citations

EFFECTIVENESS OF β-CAROTENE IN CANCER CHEMOPREVENTION

1995 • 41 citations

Primary prevention of colorectal cancer: diet and drugs

2002 • 32 citations

Effects of the interaction between the C677T 5,10-methylenetetrahydrofolate reductase polymorphism and serum B vitamins on homocysteine levels in pregnant women

2003 • 31 citations

The Role of Folate in the Prevention of Neural Tube Defects: Human and Animal Studies

2009 • 27 citations

Dietary fibre and cancer

1997 • 25 citations

Folate status in patients receiving maintenance doses of sulfasalazine.

1983 • 25 citations

Folic acid-mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells

2004 • 24 citations

NUTRITIONAL FACTORS IN CANCER PREVENTION

1998 • 20 citations

Dietary intake of folate and related micronutrients, genetic polymorphisms in MTHFR and colorectal cancer A population-based case-control study in Scotland

2002 • 16 citations

Folate Status in Germany 1997–2000

2002 • 14 citations

Transport of pteroylglutamic acid into brush border membrane vesicles from rat small intestine is a partially carrier-mediated process

1991 • 4 citations

Mean corpuscular volume (MCV) and the risk of colorectal adenoma in menopausal women.

2003 • 4 citations

Genetic polymorphisms in folate metabolism, dietary folate intake and colorectal cancer: a population-based case-control study

2001 • 2 citations