Mammary gland specific hEGF receptor transgene expression induces neoplasia and inhibits differentiation

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Growth Factors and Cancer

1991 • 2,044 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

1999 • 610 citations

The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients*

1992 • 585 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

Alteration of the quality of milk by expression of sheep β-lactoglobulin in transgenic mice

1987 • 273 citations

Amplification and over‐expression of the EGFR and erbB‐2 genes in human esophageal adenocarcinomas

1993 • 226 citations

High-level expression of biologically active human alpha 1-antitrypsin in the milk of transgenic mice.

1990 • 179 citations

The epidermal growth factor receptor as a prognostic marker: Results of 370 patients and review of 3009 patients

1994 • 161 citations

Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice

1991 • 136 citations

The epidermal growth factor receptor as a target for therapy in breast carcinoma

1994 • 134 citations

Regulatory Mechanisms in Breast Cancer

1991 • 124 citations

Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice.

1988 • 87 citations

Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas

1995 • 83 citations

Site‐selective 8‐chloroadenosine 3′,5′‐cyclic monophosphate inhibits transformation and transforming growth factor α production in Ki‐ras‐transformed rat fibroblasts

1989 • 54 citations

Transforming growth factor-alpha and epidermal growth factor receptor gene expression and action during pubertal development of the seminiferous tubule.

1992 • 50 citations

Secretory proteins compete for production in the mammary gland of transgenic mice

1995 • 49 citations

Expression of antisense epidermal growth factor receptor RNA downmodulates the malignant behavior of human colon cancer cells

1995 • 42 citations

Epidermal growth factor expression in human colon and colon carcinomas: Anti‐sense epidermal growth factor receptor rna down‐regulates the proliferation of human colon cancer cells

1995 • 34 citations

Expression of activated oncogenes in the murine mammary gland: transgenic models for human breast cancer

1991 • 31 citations

Ectopic expression of β-lactoglobulin/human serum albumin fusion genes in transgenic mice: hormonal regulation andin situ localization

1994 • 30 citations

Evaluation of c-erbB-2 Amplification in Breast Carcinoma by Differential Polymerase Chain Reaction

1994 • 27 citations

Epidermal growth factor in breast cancer

1990 • 22 citations

Whole mammary gland organ culture: Selection of appropriate gland

1973 • 20 citations

Transforming growth factor-alpha (TGFα) inhibition of parietal cell secretion: structural requirements for activity

1993 • 18 citations

EGF and TGFα modulate structural and functional differentiation of the mammary gland from pregnant mice in vitro: Possible role of the arachidonic acid pathway

1995 • 17 citations

Interaction of retinoids with steroid and peptide hormones in modulating morphological and functional differentiation of normal rat mammary epithelial cells.

1995 • 16 citations

Transgene rescue in the mammary gland is associated with transcription but does not require translation of BLG transgenes.

1997 • 16 citations

Analysis of the human tissue-type plasminogen activator gene promoter activity during embryogenesis of transgenic mice and rats

1995 • 14 citations

The role of ras gene expression and transforming growth factor α production in the etiology and progression of rodent and human breast cancer

1991 • 9 citations

Formula for Success

1967 • 1 citations