Methylenetetrahydrofolate Reductase C677T Mutation, Plasma Homocysteine, and Folate in Subjects From Northern Italy With or Without Angiographically Documented Severe Coronary Atherosclerotic Disease: Evidence for an Important Genetic-Environmental Interaction

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.

1969 • 1,846 citations

Plasma Homocysteine as a Risk Factor for Vascular Disease

1997 • 1,770 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection

1987 • 1,072 citations

The metabolic basis of inherited disease

1995 • 1,007 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1995 • 870 citations

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

1996 • 670 citations

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.

1991 • 615 citations

Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase.

1988 • 607 citations

The pathogenesis of coronary artery disease. A possible role for methionine metabolism.

1976 • 535 citations

Methylenetetrahydrofolate Reductase Polymorphism, Plasma Folate, Homocysteine, and Risk of Myocardial Infarction in US Physicians

1996 • 496 citations

Homocysteine and Thrombotic Disease

1997 • 436 citations

Genetic Predisposition to Hyperhomocysteinemia: Deficiency of Methylenetetrahydrofolate Reductase (MTHFR)

1997 • 358 citations

Thermolabile variant of 5, 10-methylenetetrahydrofolate reductaseassociated with low red-cell folates: implications for folate intake recommendations

1997 • 346 citations

The Hordaland Homocysteine Studies

2001 • 334 citations

The Effects of Folic Acid Supplementation on Plasma Total Homocysteine Are Modulated by Multivitamin Use and Methylenetetrahydrofolate Reductase Genotypes

1997 • 277 citations

Genetic Polymorphism of 5,10-Methylenetetrahydrofolate Reductase (MTHFR) as a Risk Factor for Coronary Artery Disease

1997 • 264 citations

Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study.

1996 • 263 citations

Homocysteine and Risk of Premature Coronary Heart Disease

1996 • 242 citations

Prevalence of Moderate Hyperhomocysteinemia in Patients with Early-Onset Venous and Arterial Occlusive Disease

1995 • 235 citations

Correlation of a Common Mutation in the Methylenetetrahydrofolate Reductase Gene With Plasma Homocysteine in Patients With Premature Coronary Artery Disease

1997 • 234 citations

Myocardial Infarction in Young Women in Relation to Plasma Total Homocysteine, Folate, and a Common Variant in the Methylenetetrahydrofolate Reductase Gene

1997 • 233 citations

Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.

1993 • 230 citations

Vitamin B−6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats

1994 • 198 citations

Distribution in Healthy and Coronary Populations of the Methylenetetrahydrofolate Reductase (MTHFR) C ₆₇₇ T Mutation

1996 • 173 citations

Methylenetetrahydrofolate Reductase Gene and Coronary Artery Disease

1997 • 169 citations

Genetic Polymorphism of Methylenetetrahydrofolate Reductase and Myocardial Infarction

1996 • 145 citations

Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.

1993 • 143 citations

The 677C→T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease

1997 • 139 citations

Hyperhomocysteinemia as a Risk Factor for Arterial and Venous Disease. A Review of Evidence and Relevance

1997 • 110 citations

Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction

1996 • 104 citations

A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction

1997 • 92 citations

Plasma Folate Adequacy as Determined by Homocysteine Level^a

1992 • 71 citations

More folic acid for everyone, now.

1996 • 67 citations

Molecular genetic aspects of hyperhomocysteinemia and its relation to folic acid.

1996 • 66 citations

Plasma Homocysteine and Vascular Disease

2020 • 14 citations