IFN-γ-Inducing Factor (IL-18) Increases Allergic Sensitization, Serum IgE, Th2 Cytokines, and Airway Eosinophilia in a Mouse Model of Allergic Asthma

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Simple method of estimating severity of pulmonary fibrosis on a numerical scale.

1988 • 1,435 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

1997 • 919 citations

Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

1998 • 914 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.

1998 • 775 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production

1998 • 636 citations

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

1995 • 626 citations

Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production

1996 • 606 citations

Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation

1998 • 594 citations

Activation of CD4+ T cells, increased T-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma

1993 • 593 citations

Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells.

1998 • 556 citations

IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.

1997 • 528 citations

Long-Term Risk Factors for Developing Asthma and Allergic Rhinitis: A 23-Year Follow-Up Study of College Students

1994 • 463 citations

Long Term Prevention of Allergic Lung Inflammation in a Mouse Model of Asthma by CpG Oligodeoxynucleotides

1999 • 392 citations

Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells

1997 • 385 citations

Impaired Development of Th2 Cells in IL-13-Deficient Mice

1998 • 384 citations

Interleukin-4 is required for the induction of lung Th2 mucosal immunity.

1995 • 364 citations

Selective Expression and Functions of Interleukin 18 Receptor on T Helper (Th) Type 1 but not Th2 Cells

1998 • 356 citations

CD4⁺T-Lymphocytes and Interleukin-5 Mediate Antigen-induced Eosinophil Infiltration into the Mouse Trachea

1992 • 353 citations

IL-18 Is a Potent Coinducer of IL-13 in NK and T Cells: A New Potential Role for IL-18 in Modulating the Immune Response

1999 • 351 citations

A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock

1995 • 344 citations

Effects of an antibody to interleukin-5 in a monkey model of asthma.

1995 • 335 citations

IL-18 accounts for both TNF-alpha- and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice.

1997 • 325 citations

Chronic Sinus Disease with Associated Reactive Airway Disease in Children

1984 • 319 citations

Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells.

1993 • 313 citations

Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice.

1995 • 311 citations

Endotoxin-induced serum factor that stimulates gamma interferon production

1989 • 285 citations

Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.

1996 • 268 citations

Natural Killer Cells Determine Development of Allergen-induced Eosinophilic Airway Inflammation in Mice

1999 • 248 citations

Natural history of asthma in childhood--a birth cohort study.

1991 • 238 citations

IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma- and IL-12-independent antitumor effects.

1998 • 229 citations

Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice.

1996 • 206 citations

IL-18 Augments Perforin-Dependent Cytotoxicity of Liver NK-T Cells

1998 • 203 citations

IL-10 and viral IL-10 prevent IL-4-induced IgE synthesis by inhibiting the accessory cell function of monocytes.

1993 • 197 citations

Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels.

1998 • 191 citations

IFN-γ-Inducing Factor/IL-18 Administration Mediates IFN-γ- and IL-12-Independent Antitumor Effects

1998 • 185 citations

Interleukin (IL)-4–independent Induction of Immunoglobulin (Ig)E, and Perturbation of T Cell Development in Transgenic Mice Expressing IL-13

1998 • 182 citations

Prevention of Th2-Like Cell Responses by Coadministration of IL-12 and IL-18 Is Associated with Inhibition of Antigen-Induced Airway Hyperresponsiveness, Eosinophilia, and Serum IgE Levels

1998 • 170 citations

Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses.

1996 • 143 citations

IL-1 Is an Effective Adjuvant for Mucosal and Systemic Immune Responses When Coadministered with Protein Immunogens

1999 • 136 citations

Airway epithelium expresses interleukin-18

1999 • 134 citations

Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18.

1998 • 124 citations

Interleukin 18 enhances Fas ligand expression and induces apoptosis in Fas-expressing human myelomonocytic KG-1 cells.

1997 • 111 citations

IL-5 Production by NK Cells Contributes to Eosinophil Infiltration in a Mouse Model of Allergic Inflammation

1998 • 99 citations

Functional endoscopic sinus surgery in patients with chronic sinusitis and asthma

1994 • 93 citations

Differential Capacities of CD4+, CD8+, and CD4−CD8− T Cell Subsets to Express IL-18 Receptor and Produce IFN-γ in Response to IL-18

1998 • 92 citations

Interleukin-18 Enhances Antigen-induced Eosinophil Recruitment into the Mouse Airways

1999 • 90 citations

Constitutive and Induced IL-18 Receptor Expression by Various Peripheral Blood Cell Subsets as Determined by Anti-hIL-18R Monoclonal Antibody

1998 • 86 citations

Aerosolized Recombinant Interferon-gamma Prevents Antigen-induced Eosinophil Recruitment in Mouse Trachea

1993 • 84 citations

LPS-stimulated SJL macrophages produce IL-12 and IL-18 that inhibit IgE production in vitro by induction of IFN-gamma production from CD3intIL-2R beta+ T cells.

1998 • 55 citations

LPS-Stimulated SJL Macrophages Produce IL-12 and IL-18 That Inhibit IgE Production In Vitro by Induction of IFN-γ Production from CD3intIL-2Rβ+ T Cells

1998 • 40 citations

Role of atopy in the natural history of wheeze and bronchial hyper‐responsiveness in childhood

1994 • 36 citations

Inhibition ofin vitroimmunoglobulin production by IL-12 in murine chronic graft-vs. -host disease: synergism with IL-18

1998 • 33 citations

The in vivo effects of neutralizing antibodies against IFN-γ, IL-4, or IL-10 on the humoral immune response in young and aged mice

1995 • 26 citations

TCR- and IL-1-mediated co-stimulation reveals an IL-4-independent way of T_h2 cell proliferation

1996 • 23 citations

Induction of antigen-specific IgE response in murine lymphocytes by IL-10

1995 • 23 citations

Augmentation of in vitro interleukin 10 production after in vivo administration of interleukin 18 is activated macrophage-dependent and is probably not involved in the antitumor effects of interleukin 18.

1999 • 4 citations