Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes

1981 • 736 citations

Bioactivation of foreign compounds

1985 • 733 citations

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

1982 • 706 citations

Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 • 586 citations

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

1984 • 550 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

1983 • 429 citations

Polycyclic Hydrocarbons and Carcinogenesis

1985 • 403 citations

Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene

1983 • 385 citations

Analysis of the transforming potential of the human H-ras gene by random mutagenesis.

1984 • 290 citations

Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.

1978 • 239 citations

Benzo[a]pyrene 7,8-dihydrodiol is more carcinogenic than benzo[a]pyrene in newborn mice

1977 • 214 citations

Frequency of molecular alterations affecting ras protooncogenes in human urinary tract tumors.

1985 • 191 citations

Carcinogenic epoxides of benzo[a]pyrene and cyclopenta[cd]pyrene induce base substitutions via specific transversions.

1982 • 184 citations

Three different mutations in codon 61 of the human N-rasgene detected by synthetic oligonucleotide hybridization

1984 • 167 citations

Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide

1984 • 154 citations

Mutations activating human c-Ha-ras1 protooncogene (HRAS1) induced by chemical carcinogens and depurination.

1986 • 131 citations

Evidence that binding of 7,12-dimethylbenz(a)anthracene to DNA in mouse embryo cell cultures results in extensive substitution of both adenine and guanine residues.

1983 • 116 citations

The Relation between Carcinogenic Activity and the Physical and Chemical Properties of Angular Benzacridines

1956 • 91 citations

Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen.

1982 • 91 citations

Nucleotide sequence analysis of the BALB/c murine sarcoma virus transforming gene

1985 • 45 citations

Isolation, Characterization, and Chromosome Assignment of Mouse N- ras Gene from Carcinogen-Induced Thymic Lymphoma

1984 • 42 citations

Proto-oncogene expression during two-stage carcinogenesis in mouse skin

1985 • 35 citations

Bacterial and mammalian cell mutagenicity of four optically active bay-region 3,4-diol-1,2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine.

1986 • 21 citations