Physiology and Pathophysiology of Insulin Secretion

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Regulation of insulin release by calcium.

1981 • 866 citations

Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes

1985 • 461 citations

A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling

1972 • 390 citations

A Randomized Trial of Intensive Insulin Therapy in Newly Diagnosed Insulin-Dependent Diabetes Mellitus

1989 • 314 citations

Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets

1985 • 303 citations

ATP-Sensitive K+ Channels in Pancreatic β-Cells: Spare-Channel Hypothesis

1988 • 220 citations

Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets.

1988 • 173 citations

Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy.

1988 • 172 citations

Modest decrements in plasma glucose concentration cause early impairment in cognitive function and later activation of glucose counterregulation in the absence of hypoglycemic symptoms in normal man.

1988 • 141 citations

The Ionic, Electrical, and Secretory Effects of Endogenous Cyclic Adenosine Monophosphate in Mouse Pancreatic B Cells: Studies with Forskolin*

1984 • 110 citations

Relationship between two stages of prandial insulin release in rats.

1978 • 107 citations

A New Phase Of Insulin Secretion: How Will It Contribute to Our Understanding of β-Cell Function?

1989 • 93 citations

Gastrointestinal peptides and insulin secretion

1987 • 92 citations

Pancreatic islets synthesize phospholipids de novo from glucose via acyl-dihydroxyacetone phosphate

1985 • 76 citations

Interactions of Cholecystokinin and Glucose in Rat Pancreatic Islets

1987 • 67 citations

The effect of hyperglycemia, hyperinsulinemia, and route of glucose administration on glucose oxidation and glucose storage

1982 • 63 citations

Evolution of Abnormal Insulin Secretory Responses During 48-h In Vivo Hyperglycemia

1988 • 56 citations

Intermediary Metabolism and Insulin Secretion from Isolated Rat Islets of Langerhans

1979 • 47 citations

Levels of Pancreatic Glucagon, Insulin and Glucose during Twenty-Four Hours of the Day in Normal Subjects

1975 • 42 citations

Direct effect of CNS on insulin hypersecretion in obese Zucker rats: involvement of vagus nerve

1989 • 38 citations

Prior Cholecystokinin Exposure Sensitizes Islets of Langerhans to Glucose Stimulation

1987 • 37 citations

Dual Action of Protein Kinase C Activation in the Regulation of Insulin Release by Muscarinic Agonist from Rat Insulinoma Cell Line (RINr)*

1988 • 35 citations

Effects of a phorbol ester and clomiphene on protein phosphorylation and insulin secretion in rat pancreatic islets

1988 • 32 citations

Synergistic impact of cholecystokinin and gastric inhibitory polypeptide on the regulation of insulin secretion

1988 • 30 citations

Interleukin-1α Exerts Glucose-Dependent Stimulatory and Inhibitory Effects on Islet Cell Phosphoinositide Hydrolysis and Insulin Secretion*

1989 • 26 citations

Induction of Memory in Rat Pancreatic Islets by Tolbutamide: Dependence on Ambient Glucose Level, Calcium, and Phosphoinositide Hydrolysis

1988 • 26 citations

Stimulus‐secretion coupling in the pancreatic B‐cell: The cholinergic pathway for insulin release

1986 • 25 citations

Calcium and Cyclic AMP as Synarchic Messengers

1982 • 24 citations

Interactions between cholinergic agonists and enteric factors in the regulation of insulin secretion from isolated perifused rat islets

1989 • 21 citations

A role for the vagus nerve in the etiology and maintenance of the hyperinsulinemia of genetically obese fa/fa rats.

1985 • 13 citations