Effects of a phorbol ester and clomiphene on protein phosphorylation and insulin secretion in rat pancreatic islets

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Hormone-induced redistribution of calcium-activated phospholipid-dependent protein kinase in pituitary gonadotrophs.

1985 • 296 citations

Insulin secretion: Combined effects of phorbol ester and A23187

1983 • 250 citations

Glucose metabolism in mouse pancreatic islets

1970 • 235 citations

Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase

1974 • 157 citations

Triphenylethylenes: A New Class of Protein Kinase C Inhibitors

1986 • 138 citations

Effect of tamoxifen, a nonsteroidal antiestrogen, on phospholipid/calcium-dependent protein kinase and phosphorylation of its endogenous substrate proteins from the rat brain and ovary

1985 • 125 citations

Protein kinase C translocates from cytosol to membrane upon hormone activation: Effects of thyrotropin-releasing hormone in GH3 cells

1985 • 119 citations

Insulin release independent of a rise in cytosolic free Ca²⁺ by forskolin and phorbol ester

1985 • 114 citations

Nutrient and Hormone-Neurotransmitter Stimuli Induce Hydrolysis of Polyphosphoinositides in Rat Pancreatic Islets*

1984 • 106 citations

Insulinotropic effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in rat pancreatic islets.

1980 • 106 citations

Phorbol ester induces intracellular translocation of phospholipid/Ca²⁺ ‐dependent protein kinase and stimulates amylase secretion in isolated pancreatic acini

1984 • 102 citations

Effects of Ca²⁺ and a phorbol ester on insulin secretion from islets of langerhans permeabilised by high‐voltage discharge

1985 • 101 citations

Calcium‐activated, phospholipid‐dependent protein kinase in rat pancreas islets of langerhans

1982 • 99 citations

Insulin secretory responses of a clonal cell line of simian virus 40-transformed B cells

1986 • 97 citations

Phorbol Myristate Acetate: Effect of a Tumor Promoter on Insulin Release from Isolated Rat Islets of Langerhans*

1978 • 81 citations

Protein phosphorylation in the pancreatic B-cell

1984 • 77 citations

A re-assessment of the role of protein kinase C in glucose-stimulated insulin secretion

1987 • 77 citations

The digitonin-permeabilized pancreatic islet model. Effect of myo-inositol 1,4,5-trisphosphate on Ca2+ mobilization

1985 • 62 citations

An inhibitory role for polyamines in protein kinase C activation and insulin secretion in mouse pancreatic islets

1986 • 54 citations

Synergistic Effect of a Tumor-Promoting Phorbol Ester and a Hypoglycemic Sulfonylurea upon Insulin Release^*

1983 • 54 citations

Identification and characterization of Ca2+-phospholipid-dependent protein kinase in rat islets and hamster β-cells

1984 • 54 citations

Stimulation of protein kinase C and insulin release by 1-oleoyl-2-acetyl-glycerol

1985 • 52 citations

The effects of glucose, N-acetylglucosamine, glyceraldehyde and other sugars on insulin release in vivo

1975 • 51 citations

Activity of endogenous phospholipase C and phospholipase A2 in glucose stimulated pancreatic islets

1984 • 49 citations

Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma

1984 • 44 citations

Distinct mechanisms for two amplification systems of insulin release

1987 • 39 citations

Endogenous substrate proteins for Ca2+-calmodulin-dependent, Ca2+-phospholipid-dependent and cyclic AMP-dependent protein kinases in mouse pancreatic islets

1984 • 39 citations

Involvement of protein kinase C in the phosphorylation of an insulin-granule membrane protein

1984 • 34 citations

Glucose-induced phospholipid-dependent protein phosphorylation in neonatal rat islets

1986 • 31 citations

The effects of polymyxin B, a protein kinase C inhibitor, on insulin secretion from intact and permeabilised islets of Langerhans

1986 • 30 citations

Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate

1986 • 29 citations

Substrates for cyclic AMP-dependent protein kinase in islets of Langerhans. Studies with forskolin and catalytic subunit

1985 • 28 citations

Protein kinase C and an endogenous substrate associated with adenohypophyseal secretory granules

1986 • 24 citations

In vitro effects of adenohypophysial hormones on rat pineal melatonin content and release

1987 • 11 citations