Dual Action of Protein Kinase C Activation in the Regulation of Insulin Release by Muscarinic Agonist from Rat Insulinoma Cell Line (RINr)*

Principles and procedures of statistics.

1960 • 22,587 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Use of Polyethylene Glycol to Separate Free and Antibody-Bound Peptide Hormones in Radioimmunoassays†

1971 • 1,316 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

Regulation of insulin release by calcium.

1981 • 866 citations

Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor.

1980 • 496 citations

Hormone-induced redistribution of calcium-activated phospholipid-dependent protein kinase in pituitary gonadotrophs.

1985 • 296 citations

Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. III. Uptake of⁴⁵Calcium by Isolated Islets of Langerhans1

1971 • 287 citations

[31] Calcium-activated, phospholipid-dependent protein kinase (protein kinase C) from rat brain

1983 • 281 citations

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

1985 • 267 citations

Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

1984 • 260 citations

Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C

1985 • 255 citations

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.

1986 • 254 citations

Insulin secretion: Combined effects of phorbol ester and A23187

1983 • 250 citations

Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells.

1985 • 240 citations

Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.

1986 • 194 citations

Tumor promoter phorbol myristate acetate inhibits Ca2+ influx through voltage-gated Ca2+ channels in two secretory cell lines, PC12 and RINm5F.

1986 • 178 citations

Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells.

1986 • 177 citations

Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.

1984 • 168 citations

Differential Stimulation of Inositol Phospholipid Turnover in Brain by Analogs of Oxotremorine

1984 • 134 citations

Phorbol esters inhibit alpha1 adrenergic stimulation of glycogenolysis in isolated rat hepatocytes

1984 • 114 citations

Nutrient and Hormone-Neurotransmitter Stimuli Induce Hydrolysis of Polyphosphoinositides in Rat Pancreatic Islets*

1984 • 106 citations

Insulinotropic effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in rat pancreatic islets.

1980 • 106 citations

Calcium-dependent turnover of brain polyphosphoinositides in vitro after prelabelling in vivo

1981 • 92 citations

Activation of protein kinase C by a tumor‐promoting phorbol ester in pancreatic islets

1984 • 57 citations

Stimulation of protein kinase C and insulin release by 1-oleoyl-2-acetyl-glycerol

1985 • 52 citations

Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma

1984 • 44 citations

Stimulus-Secretion Coupling of Glucose-Induced Insulin Release

1983 • 30 citations

CHOLINERGIC STIMULATION OF PHOSPHOLIPID LABELLING FROM [³²P]ORTHOPHOSPHATE IN GUINEA‐PIG CORTEX SYNAPTOSOMES IN VITRO: SUBSYNAPTOSOMAL LOCALIZATION

1974 • 29 citations

Potential mediation of somatostatin secretion from canine fundic D-cells by protein kinase c

1987 • 19 citations