Cholesterol efflux mediated by apolipoproteins is an active cellular process distinct from efflux mediated by passive diffusion

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Molecular physiology of reverse cholesterol transport.

1995 • 1,452 citations

Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI

1991 • 990 citations

Cellular Cholesterol Efflux Mediated by Cyclodextrins

1995 • 864 citations

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.

1990 • 767 citations

Mechanisms and consequences of cellular cholesterol exchange and transfer

1987 • 547 citations

Plasma Membranes Contain Half the Phospholipid and 90% of the Cholesterol and Sphingomyelin in Cultured Human Fibroblasts

1989 • 509 citations

Cholesterol transport between cells and high-density lipoproteins

1991 • 451 citations

The picomole determination of free and total cholesterol in cells in culture.

1978 • 440 citations

Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease.

1995 • 416 citations

Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice.

1994 • 372 citations

Apolipoprotein-mediated removal of cellular cholesterol and phospholipids

1996 • 346 citations

Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol.

1991 • 331 citations

Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents

1980 • 279 citations

Apolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux.

1992 • 269 citations

Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol

1991 • 259 citations

Temperature-sensitive steps in the transport of secretory proteins through the Golgi complex in exocrine pancreatic cells.

1986 • 251 citations

Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting.

1987 • 215 citations

High density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits.

1989 • 211 citations

Cyclic AMP Induces Apolipoprotein E Binding Activity and Promotes Cholesterol Efflux from a Macrophage Cell Line to Apolipoprotein Acceptors

1996 • 196 citations

Binding of high density lipoproteins to cell receptors promotes translocation of cholesterol from intracellular membranes to the cell surface.

1987 • 193 citations

Efflux of cellular cholesterol and phospholipid to lipid-free apolipoproteins and class A amphipathic peptides

1995 • 188 citations

Synthetic amphipathic helical peptides that mimic apolipoprotein A-I in clearing cellular cholesterol.

1994 • 187 citations

Mechanism of cholesterol efflux from cells. Effects of acceptor structure and concentration.

1982 • 184 citations

High density lipoprotein apolipoproteins mediate removal of sterol from intracellular pools but not from plasma membranes of cholesterol-loaded fibroblasts.

1991 • 150 citations

Temperature and energy dependence of secretory protein transport in the exocrine pancreas.

1986 • 140 citations

Efflux of lipid from fibroblasts to apolipoproteins: dependence on elevated levels of cellular unesterified cholesterol.

1992 • 129 citations

Cholesterol flux between cells and high density lipoprotein. Lack of relationship to specific binding of the lipoprotein to the cell surface.

1987 • 124 citations

Mechanism of cholesterol efflux from cells

1980 • 122 citations

HDL-Mediated Efflux of Intracellular Cholesterol Is Impaired in Fibroblasts From Tangier Disease Patients

1995 • 120 citations

Apolipoprotein A-I-cell membrane interaction: extracellular assembly of heterogeneous nascent HDL particles.

1993 • 118 citations

Role of apolipoproteins in cholesterol efflux from macrophages to lipid microemulsion: proposal of a putative model for the pre-.beta.-high-density lipoprotein pathway

1992 • 98 citations

Cellular cholesterol efflux. Role of cell membrane kinetic pools and interaction with apolipoproteins AI, AII, and Cs.

1992 • 92 citations

Receptor-mediated transport of cholesterol between cultured cells and high-density lipoproteins

1986 • 91 citations

cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J7774 macrophages.

1991 • 90 citations

Monensin and Brefeldin A Inhibit High Density Lipoprotein- mediated Cholesterol Efflux from Cholesterol-enriched Cells

1995 • 74 citations

Purification and characterization of two high-density-lipoprotein-binding proteins from rat and human liver

1989 • 74 citations

Selective Inhibition of Free Apolipoprotein-Mediated Cellular Lipid Efflux by Probucol

1996 • 73 citations

Presence and Formation of ‘Free Apolipoprotein A-I–Like’ Particles in Human Plasma

1995 • 72 citations

Cholesterol efflux from adipose cells is coupled to diacylglycerol production and protein kinase C activation

1990 • 72 citations

α‐Helical requirements for free apolipoproteins to generate HDL and to induce cellular lipid efflux

1992 • 67 citations

Mast cell-mediated inhibition of reverse cholesterol transport.

1992 • 63 citations

Purification of an apolipoprotein A binding protein from mouse adipose cells

1990 • 61 citations

Stability of free apolipoprotein A-1 concentration in serum, and its measurement in normal and hyperlipidemic subjects.

1987 • 60 citations

Oxidative Tyrosylation of HDL Enhances the Depletion of Cellular Cholesteryl Esters by a Mechanism Independent of Passive Sterol Desorption

1996 • 59 citations

Localization of an apolipoprotein A-I epitope critical for lipoprotein-mediated cholesterol efflux from monocytic cells.

1994 • 58 citations

Apolipoprotein-mediated cellular cholesterol and phospholipid efflux depend on a functional Golgi apparatus

1996 • 57 citations

The amphipathic alpha-helical repeats of apolipoprotein A-I are responsible for binding of high density lipoproteins to HepG2 cells.

1991 • 55 citations

Heterogeneity of dog interstitial fluid (peripheral lymph) high density lipoproteins: implications for a role in reverse cholesterol transport.

1985 • 54 citations

Cholesterol is poorly available for free apolipoprotein-mediated cellular lipid efflux from smooth muscle cells

1993 • 52 citations

Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells.

1993 • 52 citations

Defective regulation of phosphatidylcholine-specific phospholipases C and D in a kindred with Tangier disease. Evidence for the involvement of phosphatidylcholine breakdown in HDL-mediated cholesterol efflux mechanisms.

1996 • 47 citations

Structural domain of apolipoprotein A-I involved in its interaction with cells

1994 • 41 citations

Resistance of smooth muscle cells to assembly of high density lipoproteins with extracellular free apolipoproteins and to reduction of intracellularly accumulated cholesterol.

1992 • 40 citations

Limited proteolysis of high density lipoprotein abolishes its interaction with cell-surface binding sites that promote cholesterol efflux

1997 • 36 citations

Involvement of a cellular surface factor(s) in lipid-free apolipoprotein-mediated cellular cholesterol efflux

1995 • 32 citations

Sterol efflux from mammalian cells induced by human serum albumin-phospholipid complexes. Dependence on phospholipid acyl chain length, degree of saturation, and net charge.

1982 • 28 citations

Interaction of rabbit lipoproteins and red blood cells with liposomes of egg yolk phospholipids

1988 • 21 citations

Role of apolipoproteins A-I, A-II and C-I in cholesterol efflux from endothelial and smooth muscle cells

1993 • 11 citations

A sensitive reaction for dilute cholesterol determinations

1980 • 10 citations