Alterations in gene expression profiles and the DNA‐damage response in ionizing radiation‐exposed TK6 cells

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Expression profiling using cDNA microarrays

1999 • 1,689 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

Proliferating cell nuclear antigen (PCNA): a dancer with many partners

2003 • 1,066 citations

Role ofRAD52Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair

2002 • 962 citations

Oxidative Decay of DNA

1997 • 938 citations

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

2003 • 586 citations

The role of p53 in determining sensitivity to radiotherapy

2003 • 549 citations

Redox Control of Cell Death

2002 • 531 citations

P53 and radiation responses

2003 • 493 citations

An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III.

1994 • 477 citations

Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions

1998 • 474 citations

Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation

2000 • 459 citations

Recombinational DNA repair and human disease

2002 • 421 citations

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

1998 • 421 citations

p53-Dependent apoptosis pathways

2001 • 386 citations

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights

1998 • 381 citations

Clusterin is a secreted mammalian chaperone

2000 • 365 citations

Ku70 suppresses the apoptotic translocation of Bax to mitochondria

2003 • 358 citations

The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation

1999 • 316 citations

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents

1999 • 314 citations

Characterization of the XRCC1-DNA ligase III complexin vitroand its absence from mutant hamster cells

1995 • 279 citations

Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death

2000 • 279 citations

Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin

1999 • 276 citations

Transcriptional Activation of the Human Glutathione Peroxidase Promoter by p53

1999 • 254 citations

A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein

2003 • 251 citations

Clusterin Is an ATP−Independent Chaperone with Very Broad Substrate Specificity that Stabilizes Stressed Proteins in a Folding-Competent State

2000 • 243 citations

Oxidative nucleotide damage: consequences and prevention

2002 • 216 citations

Cyclin G Recruits PP2A to Dephosphorylate Mdm2

2002 • 205 citations

Application of complementary DNA microarray technology to carcinogen identification, toxicology, and drug safety evaluation.

1999 • 204 citations

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

2001 • 204 citations

ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth

2002 • 195 citations

Mitochondrial membrane permeabilisation by Bax/Bak

2003 • 192 citations

Mammalian DNA single‐strand break repair: an X‐ra(y)ted affair

2001 • 175 citations

XRCC3 and Rad51 Modulate Replication Fork Progression on Damaged Vertebrate Chromosomes

2003 • 165 citations

p53 from complexity to simplicity: mutant p53 stabilization, gain‐of‐function, and dominant‐negative effect

2000 • 163 citations

Transcriptional Response of Lymphoblastoid Cells to Ionizing Radiation

2003 • 158 citations

gadd153/Chop10, a Potential Target Gene of the Transcriptional Repressor ATF3

1997 • 155 citations

Mismatch Repair Processing of Carcinogen-DNA Adducts Triggers Apoptosis

1999 • 132 citations

Transcriptional Repressor Activating Transcription Factor 3 Protects Human Umbilical Vein Endothelial Cells from Tumor Necrosis Factor-α-induced Apoptosis through Down-regulation ofp53 Transcription

2002 • 130 citations

Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells

2002 • 125 citations

Dimerization, Translocation and Localization of Ku70 and Ku80 Proteins

2002 • 114 citations

RAD51 is Involved in Repair of Damage Associated with DNA Replication in Mammalian Cells

2003 • 113 citations

DNA double-strand break repair signalling: The case of RAD51 post-translational regulation

2002 • 109 citations

Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells.

2001 • 108 citations

A role of cyclin G in the process of apoptosis

1999 • 107 citations

The biological role of the Fas/FasL system during tumor formation and progression

2002 • 104 citations

Altered Regulation of Cyclin G in Human Breast Cancer and Its Specific Localization at Replication Foci in Response to DNA Damage in p53+/+ Cells

1999 • 89 citations

A role for p53 in the frequency and mechanism of mutation

2002 • 87 citations

Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation

2003 • 85 citations

A Nucleotide Excision Repair Master-Switch: p53 Regulated Coordinate Introduction of Global Genomic Repair Genes

2002 • 84 citations

Dye bias correction in dual-labeled cDNA microarray gene expression measurements.

2004 • 77 citations

DNA mismatch repair and cancer

2003 • 76 citations

Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53

2002 • 75 citations

Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells

2004 • 72 citations

Evidence That Clusterin Has Discrete Chaperone and Ligand Binding Sites

2001 • 69 citations

The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status

1995 • 65 citations

When X-ray-inducible proteins meet DNA double strand break repair

2001 • 63 citations

p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase

2000 • 59 citations

Application of genomics to the definition of the molecular basis for toxicity

2001 • 49 citations

Controlling Apoptosis by Inhibition of Caspases

2002 • 48 citations

Repair of Clustered DNA Lesions

2002 • 46 citations

Physiological function as regulation of large transcriptional programs: the cellular response to genotoxic stress

2001 • 46 citations

Involvement of Polyamines in B Cell Receptor–Mediated Apoptosis: Spermine Functions as a Negative Modulator

2001 • 41 citations

The Complexity of Radiation-Induced DNA Damage as Revealed by Exposure to Cell Extracts

1999 • 30 citations

DNA-sequence specificity of mutations at the human thymidine kinase locus

1993 • 29 citations

NMR Structure of the N-SH2 of the p85 Subunit of Phosphoinositide 3-Kinase Complexed to a Doubly Phosphorylated Peptide Reveals a Second Phosphotyrosine Binding Site

2000 • 28 citations

Apoptosis modulators as cancer therapeutics.

2001 • 26 citations

Identification and characterization of genes responsive to apoptosis: application of DNA chip technology and mRNA differential display.

2000 • 25 citations

Evaluation of the genotoxicity of the phytoestrogen, coumestrol, in AHH-1 TK+/− human lymphoblastoid cells

2001 • 22 citations

Sorting the consequences of ionizing radiation: processing of 8-oxoguanine/abasic site lesions

2002 • 20 citations

Use of Genomics in Mechanism Based Risk Assessment

2003 • 12 citations