A comparative analysis of the neuroprotective properties of competitive and uncompetitive n-methyl-d-aspartate receptor antagonists in vivo: Implications for the process of excitotoxic degeneration and its therapy

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

1969 • 1,802 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

1983 • 1,247 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system

1971 • 808 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS

1981 • 728 citations

Delayed hippocampal damage in humans following cardiorespiratory arrest

1987 • 710 citations

Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist

1985 • 673 citations

[³H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes

1988 • 453 citations

The novel anticonvulsant MK‐801 binds to the activated state of the N‐methyl‐<scp>d</scp>‐aspartate receptor in rat brain

1987 • 452 citations

Delayed neurotoxicity of excitatory amino acids In vitro

1987 • 332 citations

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

1988 • 276 citations

N‐methyl‐<scp>D</scp>‐aspartate antagonists: Ready for clinical trial in brain ischemia?

1989 • 270 citations

Excitatory amino acid antagonists

1991 • 240 citations

Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation

1988 • 216 citations

[3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain

1991 • 212 citations

Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: Dependence on calcium concentration

1986 • 204 citations

Excitatory amino acids

1991 • 194 citations

On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds

1983 • 193 citations

CGP 37849 and CGP 39551: novel and potent competitive N‐methyl‐<scp>d</scp>‐aspartate receptor antagonists with oral activity

1990 • 186 citations

Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture.

1989 • 175 citations

Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats.

1989 • 164 citations

The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents

1990 • 140 citations

Systemic administration of MK-801 prevents neuronal degeneration in rat brain

1987 • 134 citations

Synthesis and NMD A Antagonistic Properties of the Enantiomers of 4‐(3‐phosphonopropyl)piperazine‐2‐carboxylic acid (CPP) and of the unsaturated analogue (E)‐4‐(3‐phosphonoprop‐2‐enyl)piperazine‐2‐carboxylic acid (CPP‐ene)

1989 • 109 citations

Non-competitive N-methyl-D-aspartate antagonists protect against sound-induced seizures in DBA/2 mice

1989 • 84 citations

Excitatory amino acid receptors : design of agonists and antagonists

1992 • 70 citations

Anticonvulsant Activity of Two Orally Active Competitive N‐Methyl‐D‐Aspartate Antagonists, CGP 37849 and CGP 39551, Against Sound‐Induced Seizures in DBA/2 Mice and Photically Induced Myoclonus in Papio papio

1991 • 52 citations

An investigation of the mechanisms of delayed neurodegeneration caused by direct injection of quinolinate into the rat striatum in vivo

1991 • 40 citations

Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551

1990 • 29 citations

CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo

1989 • 21 citations