N‐methyl‐D‐aspartate antagonists: Ready for clinical trial in brain ischemia?

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

1993 • 2,272 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists

1988 • 1,202 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists

1988 • 983 citations

Blockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate Cortex

1987 • 920 citations

Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death

1984 • 893 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

Delayed hippocampal damage in humans following cardiorespiratory arrest

1987 • 710 citations

Agonists and antagonists for excitatory amino acid receptors

1987 • 692 citations

Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist

1985 • 673 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

1985 • 634 citations

Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

1985 • 558 citations

Calcium and Ischemic Injury

1986 • 529 citations

N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.

1987 • 529 citations

Non-competitive antagonists of excitatory amino acid receptors

1987 • 502 citations

Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro

1985 • 464 citations

Selective Neuronal Vulnerability: Morphological and Molecular Characteristics

1985 • 449 citations

Synaptic Activity Mediates Death of Hypoxic Neurons

1983 • 441 citations

Excitatory amino acid transmission

1987 • 430 citations

Historical Overview

1988 • 428 citations

A potential role for excitotoxins in the pathophysiology of spinal cord injury

1988 • 377 citations

Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 • 370 citations

Quantitative autoradiographic distribution of L-[3H]glutamate-binding sites in rat central nervous system

1984 • 353 citations

N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture.

1987 • 309 citations

The role of specific ions in glutamate neurotoxicity

1986 • 298 citations

Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice

1982 • 261 citations

MK-801 protects the neonatal brain from hypoxic-ischemic damage

1987 • 261 citations

Sigma and phencyclidine-like compounds as molecular probes in biology

1988 • 251 citations

Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path

1985 • 247 citations

The N-methyl-d-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils

1988 • 246 citations

Glutamate Antagonist Therapy Reduces Neurologic Deficits Produced by Focal Central Nervous System Ischemia

1988 • 245 citations

Glutamate-Induced Brain Damage in Infant Primates

1972 • 243 citations

Kynurenate inhibition of cell excitation decreases stroke size and deficits

1987 • 189 citations

Dextrorphan and levorphanol selectively block N-methyl-D-aspartate receptor-mediated neurotoxicity on cortical neurons.

1987 • 154 citations

Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids

1985 • 153 citations

Ketamine protects cultured neocortical neurons from hypoxic injury

1986 • 144 citations

Calcium channels and calcium channel antagonists

1987 • 141 citations

Dextromethorphan reduces neocortical ischemic neuronal damage in vivo

1988 • 131 citations

Ketamine protects hippocampal neurons from anoxia in vitro

1987 • 113 citations

Current Medical and Surgical Therapy for Cerebrovascular Disease

1987 • 108 citations

Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia

1988 • 102 citations

Long-Term Development of Selective Neuronal Loss and the Mechanism of Protection by 2-Amino-7-Phosphonoheptanoate in a Rat Model of Incomplete Forebrain Ischaemia

1988 • 102 citations

Glutamic Acid and Cerebral Function

1951 • 94 citations

Dextromethorphan protects against cerebral infarction in a rat model of hypoxia-ischemia

1988 • 92 citations

Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia

1986 • 81 citations

Protection against hypoxic/ischaemic brain damage with excitatory amino acid antagonists.

1987 • 76 citations

Phencyclidine receptor ligands attenuate cortical neuronal injury after N-methyl-D-aspartate exposure or hypoxia.

1988 • 76 citations

Pharmacology of Cerebral Ischemia 2000

2001 • 57 citations

EXCITOTOXIC MECHANISMS IN HYPOGLYCAEMIC HIPPOCAMPAL INJURY

1986 • 50 citations

Morphinans attenuate cortical neuronal injury induced by glucose deprivation in vitro

1988 • 43 citations

Pharmacologic Protection Against Ischemic Brain Damage

1983 • 21 citations

High affinity uptake of cAMP in rat brain: Inhibition by coronary vasodilators dilazep and hexobendine

1988 • 12 citations

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