PGG-Glucan, a soluble β-(1,3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-κB-like factor in human PMN: Evidence for a glycosphingolipid β-(1,3)-glucan receptor

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

NOTES ON SUGAR DETERMINATION

1926 • 5,733 citations

NOTES ON SUGAR DETERMINATION

1952 • 5,108 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

1995 • 1,436 citations

(1→3)-β-d-Glucans as biological response modifiers: a review of structure-functional activity relationships

1995 • 912 citations

Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18).

1996 • 589 citations

Plasma (1→3)-β-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes

1995 • 533 citations

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

1993 • 530 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells.

1990 • 501 citations

Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells.

1996 • 405 citations

Glycosciences: Status and Perspectives

2002 • 382 citations

Negative Interaction between the RelA(p65) Subunit of NF-κB and the Progesterone Receptor

1996 • 353 citations

Fidelity of T Cell Activation Through Multistep T Cell Receptor ζ Phosphorylation

1998 • 338 citations

Activation of the NF-κB Pathway by Inflammatory Stimuli in Human Neutrophils

1997 • 321 citations

GM3-enriched Microdomain Involved in Cell Adhesion and Signal Transduction through Carbohydrate-Carbohydrate Interaction in Mouse Melanoma B16 Cells

1998 • 303 citations

Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.

1992 • 286 citations

Immune Modulation Agents and their Mechanisms

1985 • 246 citations

Specificity of Membrane Complement Receptor Type Three (CR3) for ß-Glucans

1987 • 233 citations

A Novel Carbohydrate-Glycosphingolipid Interaction between a β-(1–3)-Glucan Immunomodulator, PGG-glucan, and Lactosylceramide of Human Leukocytes

1998 • 224 citations

A beta-glucan inhibitable receptor on human monocytes: its identity with the phagocytic receptor for particulate activators of the alternative complement pathway.

1985 • 216 citations

Chemistry and Biology of (1→3)-β-Glucans

1992 • 215 citations

The role of sphingolipids in the process of signal transduction

1997 • 190 citations

Structure and Function of Sphingoglycolipids in Transmembrane Signalling and Cell-Cell Interactions

1993 • 163 citations

Isolation and characterization of beta-glucan receptors on human mononuclear phagocytes.

1991 • 161 citations

An Unusual Mechanism for Ligand Antagonism

1998 • 157 citations

Randomized Phase I/II Trial of a Macrophage-Specific Immunomodulator (PGG-Glucan) in High-Risk Surgical Patients

1994 • 139 citations

Stimulation of human monocyte β-glucan receptors by glucan particles induces production of TNF-α and IL-1β

1992 • 138 citations

Enhanced clearance of a multiple antibiotic resistant Staphylococcus aureus in rats treated with PGG-glucan is associated with increased leukocyte counts and increased neutrophil oxidative burst activity

1998 • 137 citations

A Phase II Multicenter, Double-blind, Randomized, Placebo-Controlled Study of Three Dosages of an Immunomodulator (PGG-Glucan) in High-Risk Surgical Patients

1994 • 136 citations

Receptor binding and internalization of a water-soluble (1-->3)-beta-D-glucan biologic response modifier in two monocyte/macrophage cell lines.

1996 • 126 citations

Ligand specificity of purified complement receptor type three (CD11b/CD18, alpha m beta 2, Mac-1). Indirect effects of an Arg-Gly-Asp (RGD) sequence.

1993 • 120 citations

Molecular Cloning and Functional Expression of Murine JE (Monocyte Chemoattractant Protein 1) and Murine Macrophage Inflammatory Protein 1α Receptors

1996 • 115 citations

The lactosylceramide binding specificity of Helicobacter pylori

1998 • 108 citations

Anti-infective effect of poly-beta 1-6-glucotriosyl-beta 1-3-glucopyranose glucan in vivo

1992 • 107 citations

Receptor binding and internalization of a water-soluble (1-->3)-beta-D-glucan biologic response modifier in two monocyte/macrophage cell lines.

1996 • 106 citations

Regulation of HIV-1 Long Terminal Repeats by Interaction of C/EBP(NF-IL6) and NF-κB/Rel Transcription Factors

1996 • 104 citations

Mycobacteria-macrophage interactions. Macrophage phenotype determines the nonopsonic binding of Mycobacterium tuberculosis to murine macrophages.

1993 • 104 citations

Cryptococcus neoformans, Candida albicans, and other fungi bind specifically to the glycosphingolipid lactosylceramide (Gal beta 1-4Glc beta 1-1Cer), a possible adhesion receptor for yeasts

1990 • 103 citations

Both mannose and β-glucan receptors are involved in phagocytosis of unopsonized, heat-killed Saccharomyces cerevisiae by murine macrophages

1993 • 101 citations

Flow cytometric determination of CD11b upregulation in vivo

1993 • 92 citations

Characteristics of the β-glucan receptor of murine macrophages

1988 • 89 citations

Globoside-dependent Adhesion of Human Embryonal Carcinoma Cells, Based on Carbohydrate-Carbohydrate Interaction, Initiates Signal Transduction and Induces Enhanced Activity of Transcription Factors AP1 and CREB

1998 • 87 citations

Role of Complement Receptor Type Three and Serum Opsonins in the Neutrophil Response to Yeast

1987 • 76 citations

Lactosylceramide Stimulates Ras-GTP Loading, Kinases (MEK, Raf), p44 Mitogen-activated Protein Kinase, and c-fos Expression in Human Aortic Smooth Muscle Cells

1996 • 75 citations

Targeting of natural killer cells to mammary carcinoma via naturally occurring tumor cell-bound iC3b and beta-glucan-primed CR3 (CD11b/CD18).

1997 • 74 citations

Candida albicans stimulates arachidonic acid liberation from alveolar macrophages through alpha-mannan and beta-glucan cell wall components

1994 • 72 citations

Lipopolysaccharide Receptors and Signal Transduction Pathways in Mononuclear Phagocytes

1992 • 72 citations

Anticoagulant selection influences flow cytometric determination of CD11b upregulation in vivo and ex vivo

1995 • 69 citations

Intracellular localization of lactosylceramide, the major human neutrophil glycosphingolipid.

1987 • 67 citations

Monoclonal antibody specific for lactosylceramide.

1984 • 67 citations

Cross-linking of the beta-glucan receptor on human monocytes results in interleukin-1 receptor antagonist but not interleukin-1 production

1993 • 66 citations

PGG-Glucan activates NF-κB-like and NF-IL-6-like transcription factor complexes in a murine monocytic cell line

1997 • 65 citations

Enhancement of interleukin-1 and interleukin-2 production by soluble glucan

1987 • 63 citations

Studies on the binding of bacteria to glycolipids Two species of Propionibacterium apparently recognize separate epitopes on lactose of lactosylceramide

1988 • 59 citations

Prophylactic Anti-Infective Activity of Poly-[1-6]-β- <scp>d</scp> -Glucopyranosyl-[1-3]-β- <scp>d</scp> -Glucopyranose Glucan in a Guinea Pig Model of Staphylococcal Wound Infection

1998 • 59 citations

Tolerance to Lipopolysaccharide in Human Blood Monocytes

1995 • 56 citations

Specificity of a β-glucan receptor on macrophages from Atlantic salmon (Salmo salar L.)

1994 • 56 citations

Effect of Soluble Aminated β-1,3-D-Polyglucose on Human Monocytes: Stimulation of Cytokine and Prostaglandin E2 Production but Not Antigen-Presenting Function

1991 • 56 citations

Reduction of Infection-stimulated Periapical Bone Resorption by the Biological Response Modifier PGG Glucan

1995 • 56 citations

Activation of human phagocytes through carbohydrate antigens (CD15, sialyl-CD15, CDw17, and CDw65).

1992 • 55 citations

Activation of rat macrophages by Betafectin PGG-glucan requires cross-linking of membrane receptors distinct from complement receptor three (CR3)

1998 • 54 citations

Energetics of Leukocyte Integrin Activation

1995 • 54 citations

Isolation of a yeast heptaglucoside that inhibits monocyte phagocytosis of zymosan particles.

1989 • 52 citations

Phagocytosis of Particulate Activators of the Alternative Complement Pathway: Effects of Fibronectin

1986 • 50 citations

Enhanced production of inducible nitric oxide synthase by β-glucans in mice

2006 • 47 citations

Nonopsonic uptake of Mycobacterium avium complex by human monocytes and alveolar macrophages.

1992 • 47 citations

Enhanced production of inducible nitric oxide synthase by β-glucans in mice

1997 • 44 citations

Mobilization of Peripheral Blood Progenitor Cells by Betafectin® PGG‐Glucan Alone and in Combination with Granulocyte Colony‐Stimulating Factor

1998 • 42 citations

Perturbation of beta-glucan receptors on human neutrophils initiates phagocytosis and leukotriene B4 production.

1988 • 37 citations

A novel immunomodulator soluble aminated β-1,3-d-glucan

1994 • 34 citations

Biochemical Properties of the Ligand-binding 20-kDa Subunit of the -Glucan Receptors on Human Mononuclear Phagocytes

1995 • 33 citations

Subcellular localization of glycosphingolipids in human neutrophils

1998 • 30 citations

Comparative effects of particulate and soluble glucan on macrophages of C3H/HeN and C3H/HeJ mice

1992 • 30 citations

Novel immunomodulators with pronounced in vivo effects caused by stimulation of cytokine release

1991 • 27 citations

CDw17: a neutrophil glycolipid antigen regulated by activation.

1989 • 26 citations

Putative glycoprotein and glycolipid polymorphonuclear leukocyte receptors for the Actinomyces naeslundii WVU45 fimbrial lectin

1995 • 25 citations

Induction of a beta-1,3-D-glucan receptor in P388D1 cells treated with retinoic acid or 1,25-dihydroxyvitamin D3.

1988 • 21 citations

Macrophage Activation Decreases Macrophage Prostaglandin E2 Release in Experimental Trauma

1989 • 19 citations

Carbohydrate–Carbohydrate Interaction

1996 • 18 citations

Effect of intraperitoneally administered .BETA.-1,3-glucan, SSG, obtained from Sclerotinia sclerotiorum IFO 9395 on the functions of murine alveolar macrophages.

1991 • 18 citations

Production and isolation of rabbit anti-idiotypic antibodies directed against the human monocyte receptor for yeast beta-glucans.

1990 • 18 citations

Increases in Hematopoietic Responses Caused byβ-Glucans in Mice

1997 • 13 citations

A method to measure receptor binding of ligands with low affinity Application to plasma proteins binding assay with hemopoietic cells

1985 • 13 citations

Functional β-glucan receptor expression by a microglial cell line

1994 • 11 citations