Alteration of the tumor suppressor gene p53 in a high fraction of hormone refractory prostate cancer.

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Cancer statistics, 1993

1993 • 983 citations

Accumulation of Nuclear p53 and Tumor Progression in Bladder Cancer

1994 • 828 citations

Urologic pathology: The prostate

1977 • 821 citations

p53 Protein Accumulation and Gene Mutation in the Progression of Human Prostate Carcinoma

1993 • 488 citations

Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.

1991 • 440 citations

p53 is mutated in a subset of advanced-stage prostate cancers.

1993 • 377 citations

Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers.

1994 • 364 citations

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

1992 • 344 citations

‘Cold SSCP’: a simple, rapid and non-radioactive method for optimized single-strand conformation polymorphism analyses

1993 • 335 citations

Small Subgroup of Aggressive, Highly Proliferative Prostatic Carcinomas Defined by p53 Accumulation

1992 • 317 citations

Association of P53 Nuclear Overexpression and Tumor Progression in Carcinoma in situ of the Bladder

1994 • 221 citations

Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation.

1993 • 201 citations

p53, c-erbB-2 and the Epidermal Growth Factor Receptor in the Benign and Malignant Prostate

1992 • 169 citations

Grading of prostatic carcinoma.

1975 • 151 citations

P53 Oncogene Mutations in Human Prostate Cancer Specimens

1994 • 125 citations

Immunohistochemical Determination of P53 Protein Nuclear Accumulation in Prostatic Adenocarcinoma

1994 • 116 citations

Alterations of The P53 Gene Are Associated With The Progression Of A Human Prostate Carcinoma

1992 • 107 citations

Histological Typing of Prostate Tumours

2002 • 107 citations

P53 Gene Alterations in Human Prostate Carcinoma

1993 • 106 citations

Infrequent RAS oncogene mutations in human prostate cancer

1992 • 93 citations

Cancer risks from germline p53 mutations.

1992 • 89 citations

p53 Expression and Clinical Outcome in Prostate Cancer

1993 • 79 citations

Mutant p53 expression in prostate carcinoma

1993 • 77 citations

Comparative analysis ofp53 protein immunoreactivity in prostatic, lung and breast carcinomas

1992 • 62 citations

Dominant negative effect of a germ-line mutant p53: a step fostering tumorigenesis.

1993 • 56 citations

p53 and c-myc Expression in Stage A1 Prostatic Adenocarcinoma: Useful Prognostic Determinants?

1993 • 55 citations

Detection of both mutant and wild-type p53 protein in normal skin fibroblasts and demonstration of a shared 'second hit' on p53 in diverse tumors from a cancer-prone family with Li-Fraumeni syndrome.

1992 • 48 citations

Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer

1993 • 35 citations

Enhanced Expression of p53 mRNA and Protein in the Regressing Rat Ventral Prostate Gland

1994 • 27 citations

New Prognostic Factors in Prostatic Carcinoma

1993 • 27 citations

Update in Staging Systems

1987 • 8 citations