Immunosuppressive and Anti-inflammatory Properties of Interleukin 10

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Interleukin-10

1993 • 1,820 citations

lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines

1993 • 1,650 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

1992 • 1,259 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

1993 • 821 citations

Interleukin 10 protects mice from lethal endotoxemia.

1993 • 807 citations

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 • 752 citations

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10.

1993 • 657 citations

Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation.

1993 • 628 citations

T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

1992 • 595 citations

Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.

1993 • 504 citations

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

1994 • 429 citations

IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.

1992 • 417 citations

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

1994 • 413 citations

Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes

1994 • 396 citations

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

1994 • 367 citations

Low Affinity Interaction of Peptide-MHC Complexes with T Cell Receptors

1991 • 366 citations

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

1990 • 347 citations

Regulation of neutrophil-derived chemokine expression by IL-10.

1994 • 347 citations

Identification and induction of keratinocyte-derived IL-10.

1992 • 342 citations

Interleukin-10

1992 • 303 citations

Interferon gamma inhibits interleukin 10 production by monocytes.

1993 • 294 citations

Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation.

1994 • 288 citations

Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10 [see comments]

1992 • 247 citations

Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils.

1994 • 247 citations

Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10.

1993 • 241 citations

Interleukin-10 inhibits interleukin-8 production in human neutrophils

1994 • 213 citations

Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells

1994 • 205 citations

The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils.

1994 • 182 citations

Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock

1993 • 166 citations

Interleukin‐10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells

1994 • 151 citations

Alloantigen Recognition Is Preceded by Nonspecific Adhesion of Cytotoxic T Cells and Target Cells

1986 • 145 citations

Superantigens: Biology, immunology, and potential role in disease

1992 • 142 citations

Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures

1992 • 133 citations

Interleukin-10 and its receptor.

1994 • 102 citations

Regulation of Human Monocyte Functions by Interleukin-10

1995 • 19 citations

A Phase I Study of Interleukin-10 in Healthy Humans: Safety and Effects on Cytokine Production

1995 • 1 citations