PPARs: transcriptional effectors of fatty acids and their derivatives

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*

1999 • 2,880 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

1996 • 2,130 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

1998 • 1,408 citations

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1992 • 1,362 citations

The PPARα–leukotriene B4 pathway to inflammation control

1996 • 1,328 citations

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

2001 • 1,287 citations

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

1997 • 1,207 citations

Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay

1997 • 1,158 citations

Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors

1999 • 1,157 citations

Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

1998 • 1,138 citations

PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

2001 • 1,134 citations

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

1999 • 1,065 citations

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

2001 • 1,050 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1997 • 990 citations

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

1993 • 940 citations

A structural role for hormone in the thyroid hormone receptor

1995 • 938 citations

Role of CBP/P300 in nuclear receptor signalling

1996 • 935 citations

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

1992 • 863 citations

Terminal Differentiation of Human Breast Cancer through PPARγ

1998 • 844 citations

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: A Nuclear Receptor Signaling Pathway in Lipid Physiology

1996 • 715 citations

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor

1997 • 655 citations

Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.

1995 • 651 citations

Growth, Adipose, Brain, and Skin Alterations Resulting from Targeted Disruption of the Mouse Peroxisome Proliferator-Activated Receptor β(δ)

2000 • 641 citations

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1998 • 612 citations

Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer

2001 • 591 citations

Activators of the nuclear receptor PPARγ enhance colon polyp formation

1998 • 585 citations

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

1993 • 523 citations

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

2001 • 510 citations

The role of PPAR-γ in macrophage differentiation and cholesterol uptake

2001 • 507 citations

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma

1999 • 501 citations

Solution structure of the DMA-binding domain of the oestrogen receptor

1990 • 458 citations

Differential Expression of Peroxisome Proliferator-Activated Receptor-α, -β, and -γ during Rat Embryonic Development*

1998 • 423 citations

Novel Peroxisome Proliferator-activated Receptor (PPAR) γ and PPARδ Ligands Produce Distinct Biological Effects

1999 • 412 citations

Impaired skin wound healing in peroxisome proliferator–activated receptor (PPAR)α and PPARβ mutant mice

2001 • 407 citations

Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.

1993 • 394 citations

PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A

1997 • 379 citations

The LXRs: a new class of oxysterol receptors

1998 • 358 citations

Troglitazone action is independent of adipose tissue.

1997 • 340 citations

Isoforms of steroid receptor co-activator 1differ in their ability to potentiate transcription by the oestrogen receptor

1998 • 321 citations

Control of Human Muscle-type Carnitine Palmitoyltransferase I Gene Transcription by Peroxisome Proliferator-activated Receptor

1998 • 318 citations

Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression

1991 • 303 citations

Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ

1998 • 281 citations

Ligand Selectivity of the Peroxisome Proliferator-Activated Receptor α

1998 • 266 citations

Cloning and expression of a cDNA for mouse prostaglandin F receptor.

1994 • 232 citations

The pleiotropic functions of peroxisome proliferator-activated receptor γ

2000 • 223 citations

Peroxisome Proliferator-activated Receptor α Controls the Hepatic CYP4A Induction Adaptive Response to Starvation and Diabetes

1998 • 211 citations

Peroxisome proliferator-activated receptor agonists

1997 • 197 citations

p300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor α

1997 • 174 citations

Regulation of the Transcriptional Activity of the Peroxisome Proliferator-activated Receptor α by Phosphorylation of a Ligand-independent trans-Activating Domain

1999 • 174 citations

PPAR Tissue Distribution and Interactions with Other Hormone‐Signaling Pathways^a

1996 • 156 citations

Peroxisome Proliferator-activated Receptor Mediates Cross-talk with Thyroid Hormone Receptor by Competition for Retinoid X Receptor

1995 • 149 citations

The nuclear receptor PPARγ-bigger than fat

1998 • 141 citations

Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library

1997 • 109 citations

Ligand-induced Peroxisome Proliferator-activated Receptor α Conformational Change

1997 • 103 citations

PPARα Structure-Function Relationships Derived from Species-Specific Differences in Responsiveness to Hypolipidemic Agents

1997 • 100 citations

Peroxisome Proliferator‐Activated Receptors and Lipid Metabolism^a

1993 • 87 citations

Regulation of Gene Expression by Fatty Acids and Fibric Acid Derivatives: An Integrative Role for Peroxisome Prolif erator Activated Receptors

1992 • 76 citations

Fatty Acid Regulation of Gene Expression Its Role in Fuel Partitioning and Insulin Resistance^a

1997 • 58 citations

Chemical Probes That Differentially Modulate Peroxisome Proliferator-activated Receptor α and BLTR, Nuclear and Cell Surface Receptors for Leukotriene B4

1999 • 45 citations

Identification of fatty acid methyl ester as naturally occurring transcriptional regulators of the members of the peroxisome proliferator-activated receptor family

1996 • 45 citations