Rapamycin Dissociates p70 Activation from DNA Synthesis Stimulated by Bombesin and Insulin in Swiss 3T3 Cells

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

Rapamycin-FKBP Inhibits Cell Cycle Regulators of Proliferation in Vascular Smooth Muscle Cells

1995 • 592 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1995 • 441 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton

1993 • 277 citations

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

1995 • 243 citations

Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression

1994 • 233 citations

Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.

1992 • 166 citations

S6 Phosphorylation and the p70^s6k/p85^s6k

1994 • 148 citations

Stimulation of Phospholipase D by Epidermal Growth Factor Requires Protein Kinase C Activation in Swiss 3T3 Cells

1995 • 143 citations

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.

1992 • 119 citations

The immunosuppressant rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites

1993 • 112 citations

Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase

1993 • 82 citations

Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes.

1995 • 80 citations

Growth factors and cell proliferation

1992 • 77 citations

Arachidonic acid release by bombesin. A novel postreceptor target for heterologous mitogenic desensitization.

1990 • 76 citations

Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation.

1991 • 72 citations

Dissociation of cAMP-stimulated Mitogenesis from Activation of the Mitogen-activated Protein Kinase Cascade in Swiss 3T3 Cells

1995 • 62 citations

Effects of rapamycin on cultured hepatocyte proliferation and gene expression

1992 • 56 citations

Reduced Requirement of Mitogen-activated Protein Kinase (MAPK) Activity for Entry into the S Phase of the Cell Cycle in Swiss 3T3 Fibroblasts Stimulated by Bombesin and Insulin

1996 • 51 citations

Activation of 70‐kDa S6 kinase, induced by the cytokines interleukin‐3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation

1994 • 45 citations

Signal Transduction in Mitogenesis: Further Evidence for Multiple Pathways

1988 • 35 citations

Thapsigargin and di-tert-butylhydroquinone induce synergistic stimulation of DNA synthesis with phorbol ester and bombesin in Swiss 3T3 cells.

1994 • 30 citations

The Phosphodiesterase Inhibitor SQ 20006 Selectively Blocks Mitogen Activation of p70S6k and Transition to S Phase of the Cell Division Cycle without Affecting the Steady State Phosphorylation of eIF-4E

1995 • 19 citations