Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

1996 • 1,467 citations

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 • 1,314 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

1998 • 1,071 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

The DNA-dependent protein kinase

1999 • 896 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

1996 • 851 citations

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

1999 • 801 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Use of an oriented peptide library to determine the optimal substrates of protein kinases

1994 • 645 citations

THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA

1997 • 637 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

Control of the DNA Damage Checkpoint by Chk1 and Rad53 Protein Kinases Through Distinct Mechanisms

1999 • 535 citations

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

1998 • 526 citations

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

1996 • 502 citations

ATM associates with and phosphorylates p53: mapping the region of interaction

1998 • 494 citations

Interaction between ATM protein and c-Abl in response to DNA damage

1997 • 481 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1999 • 449 citations

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

2000 • 446 citations

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

1988 • 441 citations

Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.

1995 • 436 citations

A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination

1998 • 435 citations

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

1999 • 425 citations

Positional cloning of the gene for Nijmegen breakage syndrome

1998 • 336 citations

Targeted Disruption of the Catalytic Subunit of the DNA-PK Gene in Mice Confers Severe Combined Immunodeficiency and Radiosensitivity

1998 • 323 citations

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1988 • 306 citations

The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit

1996 • 287 citations

Cell cycle regulation of human WEE1.

1995 • 281 citations

A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage

1999 • 265 citations

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53.

1997 • 243 citations

DNA damage and the DNA-activated protein kinase

1993 • 237 citations

Wee1+-like gene in human cells

1991 • 211 citations

Localization of a Portion of Extranuclear ATM to Peroxisomes

1999 • 189 citations

ATM binds to β-adaptin in cytoplasmic vesicles

1998 • 186 citations

Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms

1997 • 186 citations

Characterization of ATM Expression, Localization, and Associated DNA-dependent Protein Kinase Activity

1998 • 185 citations

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM

1999 • 173 citations

ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation

2000 • 169 citations

Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

1997 • 160 citations

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses

1998 • 160 citations

Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

1995 • 156 citations

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

1997 • 144 citations

DNA-Dependent Protein Kinase Phosphorylation Sites in Ku 70/80 Heterodimer

1999 • 135 citations

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

1999 • 134 citations

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53

1999 • 127 citations

Recruitment of ATM Protein to Double Strand DNA Irradiated with Ionizing Radiation

1999 • 118 citations

Ataxia-telangiectasia: founder effect among north African Jews

1996 • 108 citations

The cellular responses to DNA damage

1995 • 108 citations

Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development

1998 • 106 citations

Analysis of the degradation function of Mdm2.

1999 • 104 citations

Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta

1996 • 81 citations

Phosphatidylinositol 3-kinase related kinases

1996 • 61 citations

The Use of Peptide Library for the Determination of Kinase Peptide Substrates

2003 • 49 citations

ATM immunolocalization in mouse neuronal endosomes: implications for ataxia-telangiectasia

1999 • 30 citations

Requirement of Sequences outside the Conserved Kinase Domain of Fission Yeast Rad3p for Checkpoint Control

1999 • 14 citations