Heterochromatin function in complex genomes

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

1997 • 792 citations

Formation of de novo centromeres and construction of first-generation human artificial microchromosomes

1997 • 647 citations

Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene.

1986 • 618 citations

The origin of interspersed repeats in the human genome

1996 • 595 citations

Characterization of the pufferfish (Fugu) genome as a compact model vertebrate genome

1993 • 579 citations

Further studies on the nature and causes of gene mutations.

1932 • 524 citations

Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila

1994 • 506 citations

Position effect variegation in Drosophila is associated with an altered chromatin structure.

1995 • 475 citations

Undermethylation associated with retroelement activation and chromosome remodelling in an interspecific mammalian hybrid

1998 • 460 citations

Evidence for horizontal transmission of the P transposable element between Drosophila species.

1990 • 453 citations

Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31

1999 • 433 citations

Tiggers and DNA transposon fossils in the human genome.

1996 • 421 citations

Construction of YAC–based mammalian artificial chromosomes

1998 • 414 citations

Dynamic Repositioning of Genes in the Nucleus of Lymphocytes Preparing for Cell Division

1999 • 393 citations

Transformation of white locus DNA in Drosophila: Dosage compensation, zeste interaction, and position effects

1984 • 388 citations

Gene Families: The Taxonomy of Protein Paralogs and Chimeras

1997 • 387 citations

Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation

1996 • 373 citations

Efficient Transcriptional Silencing in Saccharomyces cerevisiae Requires a Heterochromatin Histone Acetylation Pattern

1996 • 363 citations

Mapping simple repeated DNA sequences in heterochromatin of Drosophila melanogaster.

1993 • 345 citations

Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription

1996 • 328 citations

Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect.

1988 • 320 citations

A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA

1997 • 319 citations

Transposable elements are stable structural components of Drosophila melanogaster heterochromatin.

1995 • 309 citations

Time of replication of yeast centromeres and telomeres

1988 • 295 citations

Assembly of CENP-A into Centromeric Chromatin Requires a Cooperative Array of Nucleosomal DNA Contact Sites

1997 • 295 citations

Something from nothing: the evolution and utility of satellite repeats

1998 • 283 citations

Functional analysis of the chromo domain of HP1.

1995 • 259 citations

Molecular Structure of a Functional Drosophila Centromere

1997 • 252 citations

Isolation of human sequences that replicate autonomously in human cells.

1989 • 244 citations

Initiation of DNA replication at CpG islands in mammalian chromosomes

1998 • 231 citations

Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein

1990 • 229 citations

A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin

1994 • 196 citations

Cell and molecular biology

1968 • 163 citations

Arabidopsis thaliana Centromere Regions: Genetic Map Positions and Repetitive DNA Structure

1997 • 161 citations

Transgene Repeat Arrays Interact With Distant Heterochromatin and Cause Silencing in cis and trans

1997 • 159 citations

Grass genomes

1998 • 158 citations

Large-scale Chromosomal Movements During Interphase Progression in Drosophila

1998 • 142 citations

X-chromosome inactivation: molecular mechanisms and genetic consequences

1994 • 141 citations

Revising the selfish DNA hypothesis: new evidence on accumulation of transposable elements in heterochromatin

1999 • 138 citations

Transmission of a Fully Functional Human Neocentromere through Three Generations

1999 • 114 citations

Epigenetic silencing of plant transgenes as a consequence of diverse cellular defence responses

1998 • 105 citations

Differences and similarities between various tandem repeat sequences: Minisatellites and microsatellites

1997 • 103 citations

Meiotic Transmission Rates Correlate With Physical Features of Rearranged Centromeres in Maize

1998 • 99 citations

Trans-inactivation of the Drosophila brown gene: evidence for transcriptional repression and somatic pairing dependence.

1989 • 99 citations

Copy Number and Orientation Determine the Susceptibility of a Gene to Silencing by Nearby Heterochromatin in Drosophila

1996 • 94 citations

Heterochromatin protein 1 binds transgene arrays

1998 • 93 citations

Centromeres: the missing link in the development of human artificial chromosomes

1998 • 92 citations

Nuclear organization and gene expression: homologous pairing and long-range interactions

1997 • 86 citations

The Relationship Between DNA Methylation and Chromosome Imprinting in the Coccid Planococcus citri

1999 • 72 citations

Modification of the Drosophila heterochromatic mutation brownDominant by linkage alterations.

1994 • 63 citations

The Enigma of Y Chromosome Degeneration: TRAM, a Novel Retrotransposon is Preferentially Located on the Neo-Y Chromosome of Drosophila miranda

1997 • 62 citations

Do transgene arrays form heterochromatin in vertebrates?

1997 • 58 citations

Lagging-Strand, Early-Labelling, and Two-Dimensional Gel Assays Suggest Multiple Potential Initiation Sites in the Chinese Hamster Dihydrofolate Reductase Origin

1998 • 45 citations

An origin of bidirectional DNA replication is located within a CpG island at the 3' end of the chicken lysozyme gene

1999 • 29 citations

Site-Specific Retrotransposition of L1 Elements within Human Alphoid Satellite Sequences

1997 • 24 citations

From the natural evolution to the genetic manipulation of the host-range of retroviruses.

1997 • 22 citations

Fragile-X syndrome and myotonic dystrophy: parallels and paradoxes

1998 • 18 citations