X-chromosome inactivation: molecular mechanisms and genetic consequences

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus

1992 • 1,269 citations

Sex chromatin and gene action in the mammalian X-chromosome.

1962 • 1,003 citations

The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus

1992 • 983 citations

Reactivation of an Inactive Human X Chromosome: Evidence for X Inactivation by DNA Methylation

1981 • 711 citations

The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression

1993 • 692 citations

Experimental Approaches to Mammalian Embryonic Development

1987 • 596 citations

Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation

1993 • 369 citations

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1987 • 363 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos

1979 • 284 citations

Mammalian X-Chromosome Action: Inactivation Limited in Spread and in Region of Origin

1963 • 247 citations

X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryo

1993 • 235 citations

Age related reactivation of an X-linked gene

1987 • 220 citations

X-chromosome deletions in embryo-derived (EK) cell lines associated with lack of X-chromosome inactivation

1985 • 208 citations

Regional and temporal changes in the pattern of X-chromosome replication during the early post-implantation development of the female mouse

1982 • 182 citations

Phosphoglycerate Kinase Polymorphism in Kangaroos provides Further Evidence for Paternal X Inactivation

1971 • 175 citations

Sex difference in methylation of single-copy genes in human meiotic germ cells: Implications for X chromosome inactivation, parental imprinting, and origin of CpG mutations

1990 • 161 citations

X inactivation in mammalian testis is correlated with inactive X–specific transcription

1992 • 160 citations

Carrier Detection in X-Linked Agammaglobulinemia by Analysis of X-Chromosome Inactivation

1987 • 159 citations

Directed Genetic Change Model for X Chromosome Inactivation in Eutherian Mammals

1971 • 146 citations

CONTROL OF CHROMOSOME INACTIVATION

1975 • 144 citations

Expression of Xist in mouse germ cells correlates with X–chromosome inactivation

1992 • 143 citations

Expression of the X–inactivation–associated gene XIST during spermatogenesis

1992 • 140 citations

Abnormal X chromosomes in man: Origin, behavior and effects

1974 • 135 citations

Genetic Mosaics and Chimeras in Mammals

1978 • 128 citations

Center for Barr body condensation on the proximal part of the human Xq: a hypothesis

1974 • 93 citations

Structural anomalies of the X chromosome and inactivation center

1981 • 82 citations

Effect of ageing on reactivation of the human X-linked HPRT locus

1988 • 80 citations

Epigenetic inheritance in mammals

1993 • 79 citations

Mammalian X-chromosome inactivation and the XIST gene

1992 • 75 citations

Mammalian X chromosome inactivation: Testing the hypothesis of transcriptional control

1986 • 59 citations

Insights into X chromosome inactivation from studies of species variation, DNA methylation and replication, and vice versa

1990 • 51 citations

Genes on the short arm of the human X chromosome are not shared with the marsupial X

1991 • 47 citations

Mapping of the distal boundary of the X-inactivation center in a rearranged X chromosome from a female expressing XIST

1993 • 45 citations

Frequent derepression of G6PD and HPRT on the Marsupial inactive X chromosome associated with cell proliferation in vitro

1989 • 41 citations

Genetic mapping in the region of the mouse X-inactivation center

1990 • 31 citations

Studies of X-chromosome inactivation in trisomies

1989 • 27 citations

Evidence for two active X chromosomes in a human XXY triploid

1975 • 27 citations

Severe Hemophilia A in a Female by Cryptic Translocation: Order and Orientation of Factor VIII within Xq28

1993 • 21 citations

Analysis of methylation of a human X located gene which escapes X inactivation

1988 • 20 citations