Formation of de novo centromeres and construction of first-generation human artificial microchromosomes

Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector.

1992 • 1,651 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.

1993 • 888 citations

Isolation of a yeast centromere and construction of functional small circular chromosomes

1980 • 788 citations

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2

1987 • 699 citations

A Yeast Chromosomal Origin of DNA Replication Defined by Multiple Functional Elements

1992 • 634 citations

Cloning yeast telomeres on linear plasmid vectors

1982 • 625 citations

Improved telomere detection using a telomere repeat probe (TTAGGG)_ngenerated by PCR

1991 • 554 citations

DNA sequences of telomeres maintained in yeast

1984 • 552 citations

Hierarchical order in chromosome-specific human alpha satellite DNA

1987 • 510 citations

Construction of artificial chromosomes in yeast

1983 • 448 citations

CENP-E is a putative kinetochore motor that accumulates just before mitosis

1992 • 424 citations

Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen

1987 • 420 citations

Nucleotide sequence comparisons and functional analysis of yeast centromere DNAs

1982 • 399 citations

The Centromere: Hub of Chromosomal Activities

1995 • 353 citations

CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate

1992 • 340 citations

Yeast centromere DNA is in a unique and highly ordered structure in chromosomes and small circular minichromosomes

1982 • 327 citations

Visualization of centromere proteins CENP-B and CENP-C on a stable dicentric chromosome in cytological spreads

1989 • 293 citations

Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair.

1994 • 275 citations

Structure, Organization, and Sequence of Alpha Satellite DNA from Human Chromosome 17: Evidence for Evolution by Unequal Crossing-Over and an Ancestral Pentamer Repeat Shared With the Human X Chromosome

1986 • 238 citations

Unusual DNA sequences associated with the ends of yeast chromosomes

1984 • 236 citations

Long-range organization of tandem arrays of alpha satellite DNA at the centromeres of human chromosomes: high-frequency array-length polymorphism and meiotic stability.

1989 • 231 citations

Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres

1995 • 223 citations

Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells

1995 • 212 citations

Integration of human α-satellite DNA into simian chromosomes: Centromere protein binding and disruption of normal chromosome segregation

1992 • 187 citations

Localization of centromere function in a drosophila minichromosome

1995 • 186 citations

Somatic Cells Efficiently Join Unrelated DNA Segments End-to-End

1982 • 186 citations

Determinants of Rat Albumin Promoter Tissue Specificity Analyzed by an Improved Transient Expression System

1987 • 166 citations

Structure, organization, and sequence of alpha satellite DNA from human chromosome 17: evidence for evolution by unequal crossing-over and an ancestral pentamer repeat shared with the human X chromosome.

1986 • 150 citations

DNA binding and meiotic chromosomal localization of the drosophila nod kinesin-like protein

1995 • 147 citations

An Evaluation of Receptor‐Mediated Gene Transfer Using Synthetic DNA‐Ligand Complexes

1994 • 144 citations

Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage.

1996 • 143 citations

Plasmids containing many tandem copies of a synthetic lactose operator

1980 • 143 citations

Telomere directed fragmentation of mammalian chromosomes

1993 • 140 citations

Structural instability of human tandemly repeated DNA sequences cloned in yeast artificial chromosome vectors

1990 • 139 citations

Mammalian chromosome structure

1993 • 135 citations

Localization of DNA sequences required for human centromere function through an analysis of rearranged Y chromosomes

1994 • 131 citations

Isolation of chromosomal origins of replication in yeast

1980 • 130 citations

Generation of a human X-derived minichromosome using telomere-associated chromosome fragmentation.

1995 • 125 citations

Construction of functional artificial minichromosomes in the fission yeast Schizosaccharomyces pombe.

1989 • 115 citations

Instability of dicentric plasmids in yeast.

1983 • 108 citations

PCR amplification of chromosome-specific alpha satellite DNA: Definition of centromeric STS markers and polymorphic analysis

1991 • 108 citations

A genetic analysis of dicentric minichromosomes in saccharomyces cerevisiae

1987 • 101 citations

Functional analysis of a centromere from fission yeast: a role for centromere-specific repeated DNA sequences.

1990 • 100 citations

Dissecting the centromere of the human Y chromosome with cloned telomeric DNA

1994 • 96 citations

De novo formation of several features of a centromere following introduction of a Y alphoid YAC into mammalian cells

1994 • 95 citations

Somatic cells efficiently join unrelated DNA segments end-to-end.

1982 • 91 citations

β satellite DNA: Characterization and localization of two subfamilies from the distal and proximal short arms of the human acrocentric chromosomes

1992 • 86 citations

Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system.

1987 • 84 citations

Human artificial episomal chromosomes for cloning large DNA fragments in human cells

1994 • 81 citations

Liver-directed gene therapy: prospects and problems.

1994 • 72 citations

The centromere frontier: Kinetochore components, microtubule-based motility, and the CEN-value paradox

1993 • 66 citations

Interactions between the nod+ kinesin-like gene and extracentromeric sequences are required for transmission of a drosophila minichromosome

1995 • 57 citations

Sequences Upstream from the Mousec-mosOncogene May Function as a Transcription Termination Signal

1986 • 54 citations

Extrachromosomal Maintenance and Amplification of Yeast Artificial Chromosome DNA in Mouse Cells

1993 • 50 citations

Analysis of extrachromosomal structures containing human centromeric alphoid satellite DNA sequences in mouse cells

1996 • 35 citations

End-joining of DNA fragments in adenovirus transfection of human cells

1991 • 27 citations

Chromosome manipulation: a systematic approach toward understanding human chromosome structure and function.

1996 • 21 citations

A CAT expression vector with virtually no background: pUMSVOCAT.

1989 • 17 citations

Replication of Yeast DNA and Novel Chromosome Formation in Mouse Cells

1996 • 11 citations

Construction and stability of a sixfold repeated artificial gene

1987 • 9 citations

Double-minute chromosomes as megabase cloning vehicles

1992 • 4 citations