Protein Kinase A Regulates GATA-3-Dependent Activation of IL-5 Gene Expression in Th2 Cells

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes

2002 • 843 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

Lineage commitment in the immune system: the T helper lymphocyte grows up

2000 • 627 citations

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

1988 • 533 citations

Targeting of Cyclic AMP Degradation to β ₂ -Adrenergic Receptors by β-Arrestins

2002 • 496 citations

GATA transcription factors: key regulators of hematopoiesis.

1995 • 430 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.

1987 • 248 citations

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

2000 • 230 citations

cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells.

1990 • 218 citations

GATA-3-dependent enhancer activity in IL-4 gene regulation.

1998 • 205 citations

RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A.

1995 • 198 citations

Expression of cDNAs for two isoforms of the catalytic subunit of cAMP-dependent protein kinase.

1987 • 194 citations

Transcription Factors in Lymphocyte Development— T and B Cells Get Together

1999 • 169 citations

Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles.

1994 • 166 citations

Cutting Edge: GATA-3-Dependent Enhancer Activity in IL-4 Gene Regulation

1998 • 158 citations

Cyclic AMP Activates p38 Mitogen-Activated Protein Kinase in Th2 Cells: Phosphorylation of GATA-3 and Stimulation of Th2 Cytokine Gene Expression

2000 • 138 citations

T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3

2001 • 110 citations

Definition of cis-Regulatory Elements of the Mouse Interleukin-5 Gene Promoter

1995 • 100 citations

Regulation of the Human Interleukin-5 Promoter by Ets Transcription Factors

1999 • 100 citations

A nuclear factor of activated T cell-like transcription factor in mast cells is involved in IL-5 gene regulation after IgE plus antigen stimulation.

1995 • 99 citations

cAMP activates the IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4.

1993 • 92 citations

Transcriptional control in the Th1/Th2 decision

1997 • 82 citations

C/EBPβ enhances IL-4 but impairs IL-2 and IFN-γ induction in T cells

2000 • 49 citations

Set of Optimized Luciferase Reporter Gene Plasmids Compatible with Widely Used CAT Vectors

1997 • 42 citations

Cutting Edge: A-Kinase Anchor Proteins Are Involved in Maintaining Resting T Cells in an Inactive State

2002 • 30 citations

In vitro skewing of TCR transgenic CD4+ T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2.

1998 • 11 citations