Focal adhesion kinase in netrin-1 signaling

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6

1994 • 1,346 citations

Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

1994 • 1,311 citations

Autophosphorylation of the Focal Adhesion Kinase, ppl25^FAK, Directs SH2-Dependent Binding of pp60^src

1994 • 1,168 citations

Tyrosine Phosphorylation of Focal Adhesion Kinase at Sites in the Catalytic Domain Regulates Kinase Activity: a Role for Src Family Kinases

1995 • 989 citations

Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor

1996 • 982 citations

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans

1990 • 909 citations

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

1994 • 844 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

1997 • 764 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

RETRACTED: A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion

1999 • 686 citations

Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement

2000 • 661 citations

RETRACTED: Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex

2001 • 603 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors

1997 • 511 citations

Semaphorin 7A promotes axon outgrowth through integrins and MAPKs

2003 • 491 citations

UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues

1996 • 491 citations

Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1

1999 • 478 citations

frazzled Encodes a Drosophila Member of the DCC Immunoglobulin Subfamily and Is Required for CNS and Motor Axon Guidance

1996 • 456 citations

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

1995 • 423 citations

Adaptation in the chemotactic guidance of nerve growth cones

2002 • 407 citations

Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin

1995 • 393 citations

Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses

2000 • 376 citations

The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein

1997 • 372 citations

Inhibition of Cell Spreading by Expression of the C-Terminal Domain of Focal Adhesion Kinase (FAK) Is Rescued by Coexpression of Src or Catalytically Inactive FAK: a Role for Paxillin Tyrosine Phosphorylation

1997 • 329 citations

Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling

2002 • 327 citations

Short- and Long-Range Repulsion by the Drosophila Unc5 Netrin Receptor

2001 • 305 citations

Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones

2003 • 289 citations

Phospholipase C-γ and Phosphoinositide 3-Kinase Mediate Cytoplasmic Signaling in Nerve Growth Cone Guidance

1999 • 281 citations

NCAM140 Interacts with the Focal Adhesion Kinase p125 and the SRC-related Tyrosine Kinase p59

1997 • 280 citations

Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation

2002 • 263 citations

Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction

2004 • 257 citations

The Netrin Receptor UNC-40/DCC Stimulates Axon Attraction and Outgrowth through Enabled and, in Parallel, Rac and UNC-115/AbLIM

2003 • 249 citations

RETRACTED: Binding of DCC by Netrin-1 to Mediate Axon Guidance Independent of Adenosine A2B Receptor Activation

2001 • 237 citations

Activation of FAK and Src are receptor-proximal events required for netrin signaling

2004 • 233 citations

Recognition of the Neural Chemoattractant Netrin-1 by Integrins α6β4 and α3β1 Regulates Epithelial Cell Adhesion and Migration

2003 • 219 citations

The Netrin-1 Receptor DCC Promotes Filopodia Formation and Cell Spreading by Activating Cdc42 and Rac1

2002 • 203 citations

A role for netrin-1 in the guidance of cortical efferents

1997 • 202 citations

Rac1 and Cdc42 but Not RhoA or Rho Kinase Activities Are Required for Neurite Outgrowth Induced by the Netrin-1 Receptor DCC (Deleted in Colorectal Cancer) in N1E-115 Neuroblastoma Cells

2002 • 197 citations

FAK and PYK2/CAKβ in the nervous system: a link between neuronal activity, plasticity and survival?

1999 • 185 citations

The Netrin 1 ReceptorsUnc5h3andDccAre Necessary at Multiple Choice Points for the Guidance of Corticospinal Tract Axons

2002 • 181 citations

Focal adhesion kinase promotes phospholipase C-γ1 activity

1999 • 181 citations

Suppressors of Ectopic UNC-5 Growth Cone Steering Identify Eight Genes Involved in Axon Guidance inCaenorhabditis elegans

1998 • 175 citations

DCC and netrins

1998 • 137 citations

Protein Kinase A Activation Promotes Plasma Membrane Insertion of DCC from an Intracellular Pool: A Novel Mechanism Regulating Commissural Axon Extension

2004 • 136 citations

The Drosophila Netrin receptor Frazzled guides axons by controlling Netrin distribution

2000 • 123 citations

Regulation of Cdc42 Gtpase by Proline-Rich Tyrosine Kinase 2 Interacting with Psgap, a Novel Pleckstrin Homology and Src Homology 3 Domain Containing Rhogap Protein

2001 • 118 citations

Paxillin LD motifs may define a new family of protein recognition domains

1998 • 112 citations

Netrins and netrin receptors

1999 • 77 citations

Why do so many stimuli induce tyrosine phosphorylation of FAK?

1999 • 50 citations