Immunocytochemical analysis of phosphatidylinositol-specific phospholipase C in PC12 cells: predominance of the ? isoform during neural differentiation

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

Sgk1-Dependent Stimulation of Cardiac Na⁺/H⁺Exchanger Nhe1 by Dexamethasone

2013 • 842 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

The nerve growth factor: thirty-five years later.

1987 • 720 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Role of phosphoinositides in transmembrane signaling.

1990 • 491 citations

The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase

1991 • 454 citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

1991 • 373 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells

1992 • 321 citations

Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells.

1992 • 321 citations

Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

1991 • 320 citations

Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation

1987 • 310 citations

Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

1991 • 272 citations

Monoclonal antibodies to three phospholipase C isozymes from bovine brain.

1988 • 256 citations

Inositol phospholipid-specific phospholipase C: interaction of the γ isoform with tyrosine kinase

1991 • 233 citations

Regulation of Protein Kinase C by Nerve Growth Factor, Epidermal Growth Factor, and Phorbol Esters in PC12 Pheochromocytoma Cells

1989 • 219 citations

Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas.

1991 • 207 citations

Protein kinase C as a component of a nerve growth factor-sensitive phosphorylation system in PC12 cells.

1986 • 197 citations

Nerve growth factor induces protein-tyrosine phosphorylation.

1988 • 184 citations

Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases.

1986 • 169 citations

Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

1991 • 168 citations

Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform β1 is specifically, but not predominantly, located in the nucleus

1993 • 165 citations

Calcium-Dependent Nerve Growth Factor-Stimulated Hydrolysis of Phosphoinositides in PC12 Cells

1987 • 127 citations

Molecular and Biochemical Characterization of the Human trk Proto-Oncogene

1989 • 124 citations

Inhibition of Serum- and Ras-Stimulated DNA Synthesis by Antibodies to Phospholipase C

1990 • 122 citations

S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C.

1989 • 99 citations

Alterations of Lipid Metabolism in Response to Nerve Growth Factor

1982 • 97 citations

The importance of both early and delayed responses in the biological actions of nerve growth factor

1984 • 88 citations

Temporal changes in intracellular distribution of protein kinase C in Swiss 3T3 cells during mitogenic stimulation with insulin-like growth factor I and bombesin: Translocation to the nucleus follows rapid changes in nuclear polyphosphoinositides

1991 • 70 citations

Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts.

1991 • 69 citations

Enhancement of phospholipase C delta 1 activity in the aortas of spontaneously hypertensive rats.

1992 • 67 citations

Phospholipase C I and II brain isozymes: immunohistochemical localization in neuronal systems in rat brain.

1988 • 66 citations

Production of 1,2‐Diacylglycerol in PC12 Cells by Nerve Growth Factor and Basic Fibroblast Growth Factor

1990 • 57 citations

Discrete subcellular localization of phosphoinositidase C β, γ and δ in PC12 rat pheochromocytoma cells

1992 • 56 citations

Nuclear matrix-bound replicational sites detected in situ by 5-bromodeoxyuridine

1992 • 54 citations

Uptake and phosphorylation of phosphatidylinositol by rat liver nuclei. Role of phosphatidylinositol transfer protein

1990 • 49 citations

Lipid phosphorylation in isolated rat liver nuclei Synthesis of polyphosphoinositides at subnuclear level

1989 • 48 citations

Existence of Phosphoinositide-Specific Phospholipase C in Rat Liver Nuclei and Its Change during Liver Regeneration1

1992 • 48 citations

Intranuclear localization of phospholipids by ultrastructural cytochemistry.

1992 • 37 citations

Immunohistochemical localization of a brain isozyme of phospholipase C (PLC III) in astroglia in rat brain

1989 • 35 citations

Nuclear inositol lipids in friend erythroleukemia cells. Changes related to differentiation induced by hexamethylenebisacetamide

1990 • 16 citations

Subcellular Localization of Glycolipids as Revealed by Immuno-Electronmicroscopy.

1992 • 16 citations

Inositol lipids in friend erythroleukemia cells: Evidence for changes in nuclear metabolism after differntiation

1991 • 13 citations

Characterization of phosphatidylinositol phospholipase C activity in human melanoma

1990 • 7 citations