Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas.

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 • 881 citations

Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.

1983 • 792 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

HER-2/neu oncogene protein and prognosis in breast cancer.

1989 • 579 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles.

1981 • 412 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

Confirmation of a prognostic index in primary breast cancer

1987 • 311 citations

Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines.

1987 • 266 citations

Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.

1989 • 262 citations

Structure and expression of c‐erbB‐2 and EGF receptor genes in inflammatory and non‐inflammatory breast cancer: Prognostic significance

1989 • 197 citations

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

1990 • 195 citations

Effect of Phospholipase C-γ Overexpression on PDGF-induced Second Messengers and Mitogenesis

1990 • 170 citations

Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

1991 • 168 citations

A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity

1989 • 160 citations

Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.

1989 • 145 citations

Tyrosine Phosphorylation of Phospholipase C-II in Vitro by the Epidermal Growth Factor Receptor

1989 • 145 citations

Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells.

1990 • 136 citations

Inhibition of Serum- and Ras-Stimulated DNA Synthesis by Antibodies to Phospholipase C

1990 • 122 citations

Emerging Impact of Flow Cytometry in Predicting Recurrence and Survival in Breast Cancer Patients

1985 • 120 citations

Epidermal growth factor receptor (EGFr) status associated with failure of primary endocrine therapy in elderly postmenopausal patients with breast cancer

1988 • 117 citations

Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis.

1988 • 110 citations

The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency.

1991 • 86 citations

Characteristics of antibodies to the epidermal growth factor receptor-kinase

1983 • 79 citations

Relationship between ploidy and steroid hormone receptors in primary invasive breast cancer

1986 • 73 citations

Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains.

1990 • 69 citations

The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.

1990 • 66 citations

Platelet-Derived Growth Factor Induces Rapid and Sustained Tyrosine Phosphorylation of Phospholipase C-γ in Quiescent BALB/c 3T3 Cells

1989 • 60 citations

Expression of platelet-derived growth factor (PDGF)-related transcripts and synthesis of biologically active PDGF-like proteins by human malignant epithelial cell lines.

1988 • 52 citations

Phospholipase C gamma complexes with ligand-activated platelet-derived growth factor receptors. An intermediate implicated in phospholipase activation

1991 • 47 citations

Characterization and cDNA Cloning of Phospholipase C-γ, a Major Substrate for Heparin-Binding Growth Factor 1 (Acidic Fibroblast Growth Factor)-Activated Tyrosine Kinase

1990 • 35 citations

Overexpression of Phospholipase C-γ in NIH 3T3 Fibroblasts Results in Increased Phosphatidylinositol Hydrolysis in Response to Platelet-Derived Growth Factor and Basic Fibroblast Growth Factor

1990 • 34 citations

The erbB-2 Mitogenic Signaling Pathway: Tyrosine Phosphorylation of Phospholipase C-γ and GTPase-Activating Protein Does Not Correlate with erbB-2 Mitogenic Potency

1991 • 21 citations

An observation of DNA ploidy, histological grade, and immunoreactivity for tumour‐related antigens in primary and metastatic breast carcinoma

1989 • 20 citations

The Carboxy-Terminal Domains of erbB-2 and Epidermal Growth Factor Receptor Exert Different Regulatory Effects on Intrinsic Receptor Tyrosine Kinase Function and Transforming Activity

1990 • 18 citations